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Biology and Biochemistry

D-Index
49
Citations
8527
World Ranking
18036
National Ranking
484

Overview

Yingying Le is affiliated with the Chinese Academy of Sciences in China. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions in related subfields such as Molecular Biology, Rehabilitation, Biomedical Engineering, Cell Biology, and Physiology.

The scientist has worked extensively on topics including:

  • Wound Healing and Treatments
  • 3D Printing in Biomedical Research
  • S100 Proteins and Annexins
  • Cellular Mechanics and Interactions
  • Adipose Tissue and Metabolism
  • Computational Drug Discovery Methods
  • Electrospun Nanofibers in Biomedical Applications

Le's publication record includes papers in various scientific journals and research venues. Some notable recent papers are:

  • "Metrnl deficiency decreases blood HDL cholesterol and increases blood triglyceride," 2020, Acta Pharmacologica Sinica
  • "Mesoporous silica nanoparticles inflame tumors to overcome anti-PD-1 resistance through TLR4-NFκB axis," 2021, Journal for ImmunoTherapy of Cancer
  • "The Contribution of Chemoattractant GPCRs, Formylpeptide Receptors, to Inflammation and Cancer," 2020, Frontiers in Endocrinology
  • "Quercetin promotes human epidermal stem cell proliferation through the estrogen receptor/β-catenin/c-Myc/cyclin A2 signaling pathway," 2020, Acta Biochimica et Biophysica Sinica
  • "Discovery of Toxin-Degrading Enzymes with Positive Unlabeled Deep Learning," 2024, ACS Catalysis

Frequent coauthors in Le's work include Jihui Ju, Pengxiang Ji, Ruixing Hou, Yi Fu, and Qian-Nan Hu.

The scientist publishes regularly in several venues, with the most frequent being:

  • Acta Biochimica et Biophysica Sinica
  • Materials Today Communications
  • The FASEB Journal
  • Biotechnology and Bioengineering
  • bioRxiv (Cold Spring Harbor Laboratory)

Best Publications

  • Formyl-peptide receptors revisited

    Yingying Le;Philip M Murphy;Ji Ming Wang

  • Chemokines and chemokine receptors: their manifold roles in homeostasis and disease.

    Yingying Le;Ye Zhou;Pablo Iribarren;Ji Ming Wang

  • Amyloid β42 Activates a G-Protein-Coupled Chemoattractant Receptor, FPR-Like-1

    Yingying Le;Wanghua Gong;H. Lee Tiffany;Alexei Tumanov

  • Pleiotropic roles of formyl peptide receptors

    Yingying Le;Joost J Oppenheim;Ji Ming Wang

  • Humanin, a newly identified neuroprotective factor, uses the G protein-coupled formylpeptide receptor-like-1 as a functional receptor.

    Guoguang Ying;Pablo Iribarren;Ye Zhou;Wanghua Gong

  • Utilization of Two Seven-Transmembrane, G Protein-Coupled Receptors, Formyl Peptide Receptor-Like 1 and Formyl Peptide Receptor, by the Synthetic Hexapeptide WKYMVm for Human Phagocyte Activation

    Yingying Le;Wanghua Gong;Baoqun Li;Nancy M. Dunlop

  • Role of resistin in inflammation and inflammation-related diseases.

    Shan Shan Pang;Ying Ying Le

  • Amyloid deposition and inflammation in APPswe/PS1dE9 mouse model of Alzheimer's disease.

    Lingfei Ruan;Zhoujun Kang;Gang Pei;Yingying Le

  • Beta amyloid peptide (Abeta42) is internalized via the G-protein-coupled receptor FPRL1 and forms fibrillar aggregates in macrophages.

    Hiroshi Yazawa;Zu-Xi Yu;Takeda;Yingying Le

  • Resveratrol differentially modulates inflammatory responses of microglia and astrocytes

    Xiaofeng Lu;Lili Ma;Lingfei Ruan;Yan Kong

  • The neurotoxic prion peptide fragment PrP(106-126) is a chemotactic agonist for the G protein-coupled receptor formyl peptide receptor-like 1.

    Yingying Le;Hiroshi Yazawa;Wanghua Gong;Zuxi Yu

  • Formylpeptide Receptor FPR and the Rapid Growth of Malignant Human Gliomas

    Ye Zhou;Xiuwu Bian;Yingying Le;Wanghua Gong

  • Bacterial Lipopolysaccharide Selectively Up-Regulates the Function of the Chemotactic Peptide Receptor Formyl Peptide Receptor 2 in Murine Microglial Cells

    You-Hong Cui;Yingying Le;Wanghua Gong;Paul Proost

  • Toll-like receptors in inflammation of the central nervous system.

    Yan Kong;Yingying Le

  • Cutting Edge: A Critical Role for the G Protein-Coupled Receptor mFPR2 in Airway Inflammation and Immune Responses

    Keqiang Chen;Keqiang Chen;Yingying Le;Ying Liu;Wanghua Gong

  • Role of formyl peptide receptor-like 1 (FPRL1/FPR2) in mononuclear phagocyte responses in Alzheimer disease.

    Pablo Iribarren;Ye Zhou;Jinyue Hu;Yingying Le;Yingying Le

  • High glucose induces renal mesangial cell proliferation and fibronectin expression through JNK/NF-κB/NADPH oxidase/ROS pathway, which is inhibited by resveratrol.

    Lanyu Zhang;Shanshan Pang;Bo Deng;Lihua Qian

  • Receptors for chemotactic formyl peptides as pharmacological targets.

    Yingying Le;Yiming Yang;Youhong Cui;Hiroshi Yazawa

  • Formylpeptide receptor-2 contributes to colonic epithelial homeostasis, inflammation, and tumorigenesis.

    Keqiang Chen;Mingyong Liu;Mingyong Liu;Ying Liu;Ying Liu;Teizo Yoshimura

  • Resveratrol Protects Vascular Endothelial Cells from High Glucose–Induced Apoptosis through Inhibition of NADPH Oxidase Activation–Driven Oxidative Stress

    Feng Chen;Li-Hua Qian;Bo Deng;Zhi-Min Liu

Frequent Co-Authors

Ji Ming Wang
Ji Ming Wang National Institutes of Health
Wanghua Gong
Wanghua Gong Leidos (United States)
Lino Tessarollo
Lino Tessarollo National Institutes of Health
Philip M. Murphy
Philip M. Murphy National Institutes of Health
Thomas J. Rogers
Thomas J. Rogers Temple University
Paul Proost
Paul Proost KU Leuven
Joost J. Oppenheim
Joost J. Oppenheim National Institutes of Health
Richard D. Ye
Richard D. Ye Chinese University of Hong Kong, Shenzhen
Benoit Viollet
Benoit Viollet Institut Cochin
O. M. Zack Howard
O. M. Zack Howard National Institutes of Health

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