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Chemistry

D-Index
58
Citations
11376
World Ranking
10670
National Ranking
2941

Overview

Francis Johnson is affiliated with Stony Brook University in the United States. Their research primarily spans several interconnected fields including Dentistry, Biochemistry, Genetics and Molecular Biology, and Medicine.

The scientist's work focuses notably on periodontics and molecular medicine, with subfields of study that also cover immunology, radiology, nuclear medicine and imaging, and pharmacology. Their research topics demonstrate a particular emphasis on oral microbiology and periodontitis research, curcumin's biomedical applications, nephrotoxicity and medicinal plants, endodontics and root canal treatments, immune response and inflammation, drug-induced hepatotoxicity and protection, and DNA repair mechanisms.

Francis Johnson has produced multiple papers addressing these themes. Some recent publications include:

  • Chemically-Modified Curcumin 2.24: A Novel Systemic Therapy for Natural Periodontitis in Dogs, 2020, Journal of Experimental Pharmacology
  • Novel Chemically Modified Curcumin (CMC) Derivatives Inhibit Tyrosinase Activity and Melanin Synthesis in B16F10 Mouse Melanoma Cells, 2021, Biomolecules
  • A Novel Modified-Curcumin Promotes Resolvin-Like Activity and Reduces Bone Loss in Diabetes-Induced Experimental Periodontitis, 2021, Journal of Inflammation Research
  • Structural and mechanistic insights into the transport of aristolochic acids and their active metabolites by human serum albumin, 2024, Journal of Biological Chemistry
  • A novel modified-curcumin 2.24 resolves inflammation by promoting M2 macrophage polarization, 2023, Scientific Reports

The frequent coauthors collaborating with Francis Johnson include:

  • Lorne M. Golub
  • Hsi-Ming Lee
  • Ying Gu
  • Jie Deng
  • Joseph Scaduto

The scientist's published work appears often in established venues such as the Journal of Experimental Pharmacology, Journal of Inflammation Research, Frontiers in Dental Medicine, Biomolecules, and the Journal of Biological Chemistry.

Best Publications

  • Bleomycin-induced strand-scission of DNA. Mechanism of deoxyribose cleavage.

    L Giloni;M Takeshita;F Johnson;C Iden

  • Oligodeoxynucleotides containing synthetic abasic sites. Model substrates for DNA polymerases and apurinic/apyrimidinic endonucleases.

    M. Takeshita;Chien-Neng Chang;F. Johnson;S. Will

  • Substrate specificity of Fpg protein. Recognition and cleavage of oxidatively damaged DNA.

    J Tchou;V Bodepudi;S Shibutani;I Antoshechkin

  • NMR structural studies of the ionizing radiation adduct 7-hydro-8-oxodeoxyguanosine (8-oxo-7H-dG) opposite deoxyadenosine in a DNA duplex. 8-Oxo-7H-dG(syn).cntdot.dA(anti) alignment at lesion site

    Michael Kouchakdjian;Veeraiah Bodepudi;Shinya Shibutani;Moises Eisenberg

  • Site-specific mutagenesis using a gapped duplex vector: A study of translesion synthesis past 8-oxodeoxyguanosine in E. coli

    M. Moriya;C. Ou;V. Bodepudi;F. Johnson

  • High Affinity InhA Inhibitors with Activity against Drug-Resistant Strains of Mycobacterium tuberculosis

    Todd J. Sullivan;James J. Truglio;James J. Truglio;Melissa E. Boyne;Polina Novichenok

  • Mutagenic potency of exocyclic DNA adducts: marked differences between Escherichia coli and simian kidney cells.

    M Moriya;W Zhang;F Johnson;A P Grollman

  • Compounds Related to Podophyllotoxin. XII. Podophyllotoxone, Picropodophyllone and Dehydropodophyllotoxin1

    Walter J. Gensler;Francis Johnson;A. David B. Sloan

  • Influence of the Oxidatively Damaged Adduct 8-Oxodeoxyguanosine on the Conformation, Energetics, and Thermodynamic Stability of a DNA Duplex

    Plum Ge;Grollman Ap;Johnson F;Breslauer Kj

  • Streptonigrin. 1. Structure-activity relationships among simple bicyclic analogues. Rate dependence of DNA degradation on quinone reduction potential.

    Iftikhar A. Shaikh;Francis Johnson;Arthur P. Grollman

  • Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms.

    Jie Lu;John S. Kovach;Francis Johnson;Jeffrey Chiang

  • Steric Interference in Allylic and Pseudo-Allylic Systems. I. Two Stereochemical Theorems

    Francis Johnson;Sudarshan K. Malhotra

  • Thermodynamic consequences of an abasic lesion in duplex DNA are strongly dependent on base sequence.

    C A Gelfand;G E Plum;A P Grollman;F Johnson

  • Inhibition of the Bacterial Enoyl Reductase FabI by Triclosan: A Structure−Reactivity Analysis of FabI Inhibition by Triclosan Analogues†

    Sharada Sivaraman;Todd J. Sullivan;Francis Johnson;Polina Novichenok

  • NMR Characterization of a DNA Duplex Containing the Major Acrolein-derived Deoxyguanosine Adduct γ-OH-1,-N 2-Propano-2′-deoxyguanosine

    Carlos R. de los Santos;Tanya Zaliznyak;Francis Johnson

  • Safety, Tolerability, and Preliminary Activity of LB-100, an Inhibitor of Protein Phosphatase 2A, in Patients with Relapsed Solid Tumors: An Open-Label, Dose Escalation, First-in-Human, Phase I Trial.

    Vincent Chung;Aaron S. Mansfield;Fadi Braiteh;Donald Richards

  • Lack of recognition by global-genome nucleotide excision repair accounts for the high mutagenicity and persistence of aristolactam-DNA adducts

    Victoria S. Sidorenko;Jung-Eun Yeo;Radha R. Bonala;Francis Johnson

  • A New Method for Straightening DNA Molecules for Optical Restriction Mapping

    Hiroki Yokota;Forrester Johnson;Hongbo Lu;R. Maxwell Robinson

  • Apolipoprotein (apo) A-I production and mRNA abundance explain plasma apoA-I and high density lipoprotein differences between two nonhuman primate species with high and low susceptibilities to diet-induced hypercholesterolemia.

    M Sorci-Thomas;M M Prack;N Dashti;F Johnson

  • Mutagenesis by acrolein-derived propanodeoxyguanosine adducts in human cells.

    In-Young Yang;Grace Chan;Holly Miller;Yanhe Huang

  • 8-oxodGTP incorporation by DNA polymerase beta is modified by active-site residue Asn279.

    Holly Miller;Rajendra Prasad;Samuel H. Wilson;Francis Johnson

Frequent Co-Authors

Arthur P. Grollman
Arthur P. Grollman Stony Brook University
Lorne M. Golub
Lorne M. Golub Stony Brook University
Shinya Shibutani
Shinya Shibutani Stony Brook University
Kenneth J. Breslauer
Kenneth J. Breslauer Rutgers, The State University of New Jersey
Dinshaw J. Patel
Dinshaw J. Patel Memorial Sloan Kettering Cancer Center
David L. Williams
David L. Williams Stony Brook University
Takehiko Nohmi
Takehiko Nohmi Gifu University
Peter J. Tonge
Peter J. Tonge Stony Brook University
Robert J. Turesky
Robert J. Turesky University of Minnesota
Caroline Kisker
Caroline Kisker University of Würzburg

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