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Medicine

D-Index
95
Citations
43854
World Ranking
9910
National Ranking
5098

Overview

Dennis C. Sgroi is affiliated with Harvard University in the United States. Their research spans multiple interconnected fields, primarily within biochemistry, genetics, molecular biology, and medicine, with a strong focus on cancer-related studies.

The main fields of study for Dennis C. Sgroi include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Their subfields of study reflect specialized areas of cancer and medical research:

  • Cancer Research
  • Pulmonary and Respiratory Medicine
  • Genetics
  • Oncology
  • Pathology and Forensic Medicine

Dennis C. Sgroi's research covers several key topics, emphasizing cancer treatment and molecular diagnostics:

  • Breast Cancer Treatment Studies
  • Advanced Breast Cancer Therapies
  • Cancer Genomics and Diagnostics
  • Estrogen and related hormone effects
  • Genetic factors in colorectal cancer
  • Breast Lesions and Carcinomas
  • Cancer-related Molecular Pathways

The scientist has contributed to recent publications, with a focus on cancer biology and therapeutic response. Notable papers include:

  • A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns, 2020, Nature Communications
  • Sex differences in oncogenic mutational processes, 2020, Nature Communications
  • CD8 + T cell immunity blocks the metastasis of carcinogen-exposed breast cancer, 2021, Science Advances
  • Breast Cancer Index Is a Predictive Biomarker of Treatment Benefit and Outcome from Extended Tamoxifen Therapy: Final Analysis of the Trans-aTTom Study, 2022, Clinical Cancer Research
  • Breast Cancer Index (BCI) and prediction of benefit from extended aromatase inhibitor (AI) therapy (tx) in HR+ breast cancer: NRG oncology/NSABP B-42., 2021, Journal of Clinical Oncology

Frequent co-authors collaborating with Dennis C. Sgroi include:

  • Catherine A. Schnabel
  • Kai Treuner
  • Gurnit Atwal
  • Fátima Al-Shahrour
  • Esther Rheinbay

The primary venues where Dennis C. Sgroi frequently publishes are:

  • Cancer Research
  • Clinical Cancer Research
  • Nature Communications
  • UNC Libraries
  • Journal of Clinical Oncology

Best Publications

  • Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion

    Akira Orimo;Piyush B. Gupta;Dennis C. Sgroi;Fernando Arenzana-Seisdedos

  • Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

    Min Yu;Aditya Bardia;Ben S. Wittner;Shannon L. Stott

  • Sequence analysis of mutations and translocations across breast cancer subtypes

    Shantanu Banerji;Kristian Cibulskis;Claudia Rangel-Escareno;Kristin K. Brown

  • Efficacy of Neoadjuvant Cisplatin in Triple-Negative Breast Cancer

    Daniel P. Silver;Andrea L. Richardson;Aron C. Eklund;Zhigang C. Wang

  • A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen

    Xiao Jun Ma;Zuncai Wang;Paula D. Ryan;Steven J. Isakoff

  • Gene expression profiles of human breast cancer progression

    Xiao-Jun Ma;Ranelle Salunga;J. Todd Tuggle;Justin Gaudet

  • Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon

    Michael Overholtzer;Jianmin Zhang;Gromoslaw A. Smolen;Beth Muir

  • Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility

    Min Yu;Min Yu;Aditya Bardia;Nicola Aceto;Francesca Bersani

  • Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification.

    Morgan L. Maeder;Stacey Thibodeau-Beganny;Anna Osiak;David A. Wright

  • Patterns of somatic structural variation in human cancer genomes

    Yilong Li;Nicola D Roberts;Jeremiah A Wala;Jeremiah A Wala;Ofer Shapira;Ofer Shapira

  • Epidermal Growth Factor Receptor Mutations and Gene Amplification in Non–Small-Cell Lung Cancer: Molecular Analysis of the IDEAL/INTACT Gefitinib Trials

    Daphne W. Bell;Thomas J. Lynch;Sara M. Haserlat;Patricia L. Harris

  • Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling.

    Maurice Phillip DeYoung;Peter Horak;Avi Sofer;Dennis Sgroi

  • Gene expression profiling of the tumor microenvironment during breast cancer progression

    Xiao-Jun Ma;Sonika Dahiya;Elizabeth A Richardson;Mark G. Erlander

  • Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752

    Gromoslaw A. Smolen;Raffaella Sordella;Beth Muir;Gayatry Mohapatra

  • Planning cancer control in Latin America and the Caribbean

    Paul E. Goss;Brittany L. Lee;Brittany L. Lee;Tanja Badovinac-Crnjevic;Kathrin Strasser-Weippl

  • In Vivo Gene Expression Profile Analysis of Human Breast Cancer Progression

    Dennis C. Sgroi;Sarena Teng;Greg Robinson;Rebbecca LeVangie

  • Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor

    Dejan Juric;Pau Castel;Malachi Griffith;Obi L. Griffith

  • The B lymphocyte adhesion molecule CD22 interacts with leukocyte common antigen CD45RO on T cells and α2–6 sialyltransferase, CD75, on B cells

    Ivan Stamenkovic;Dennis Sgroi;Alejandro Aruffo;Man Sun Sy

  • Germ-line BRCA1 mutations in Jewish and non-Jewish women with early-onset breast cancer.

    Michael G. FitzGerald;Deborah J. MacDonald;Michael Krainer;Ingrid Hoover

  • The molecular pathology of breast cancer progression.

    Alessandro Bombonati;Dennis C Sgroi

Frequent Co-Authors

Daniel A. Haber
Daniel A. Haber Harvard University
Paul E. Goss
Paul E. Goss Harvard University
Sridhar Ramaswamy
Sridhar Ramaswamy Harvard University
Barbara L. Smith
Barbara L. Smith Harvard University
Aditya Bardia
Aditya Bardia Harvard University
Stuart J. Schnitt
Stuart J. Schnitt Brigham and Women's Hospital
José Baselga
José Baselga Memorial Sloan Kettering Cancer Center
Shyamala Maheswaran
Shyamala Maheswaran Harvard University
Ivan Stamenkovic
Ivan Stamenkovic Harvard University
Susan Bonner-Weir
Susan Bonner-Weir Harvard University

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