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Biology and Biochemistry

D-Index
45
Citations
16371
World Ranking
19035
National Ranking
7769

Overview

Ann-Bin Shyu is a researcher affiliated with The University of Texas Health Science Center at Houston in the United States. Their research primarily lies within the field of Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology as a subfield.

Shyu's work covers several main topics including RNA Research and Splicing, Cancer-related gene regulation, and RNA modifications and cancer. These areas demonstrate a concentration on understanding gene expression regulation at the RNA level and its implications in cancer biology.

The scientist has contributed to multiple publications in notable scientific venues. Their recent papers include:

  • Tob2 phosphorylation regulates global mRNA turnover to reshape transcriptome and impact cell proliferation, 2020, published in RNA
  • Author Correction: CFIm25 links alternative polyadenylation to glioblastoma tumour suppression, 2022, published in Nature

Collaboration is evident in the frequent coauthorship of Shyu with these researchers:

  • Chyi-Ying A. Chen
  • Krista Strouz
  • Kai-Lieh Huang
  • Chioniso Patience Masamha
  • Zheng Xia

The venues where Shyu has recently published include:

  • RNA
  • Nature

Best Publications

  • AU-rich elements: characterization and importance in mRNA degradation.

    Chyi-Ying A. Chen;Ann-Bin Shyu

  • The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism

    Reinhard Winzen;Michael Kracht;Birgit Ritter;Arno Wilhelm

  • RNA stabilization by the AU‐rich element binding protein, HuR, an ELAV protein

    Sheila S.Y. Peng;Chyi Ying A. Chen;Nianhua Xu;Ann Bin Shyu

  • The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways.

    Ann-Bin Shyu;M. E. Greenberg;J. G. Belasco

  • Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.

    Ann-Bin Shyu;Joel G. Belasco;Michael E. Greenberg

  • Concerted action of poly(A) nucleases and decapping enzyme in mammalian mRNA turnover

    Akio Yamashita;Tsung Cheng Chang;Yukiko Yamashita;Wenmiao Zhu

  • Messenger RNA regulation: to translate or to degrade.

    Ann-Bin Shyu;Miles F Wilkinson;Ambro van Hoof

  • Mammalian miRNA RISC Recruits CAF1 and PABP to Affect PABP-Dependent Deadenylation

    Marc R. Fabian;Géraldine Mathonnet;Thomas Sundermeier;Hansruedi Mathys

  • Modulation of the fate of cytoplasmic mRNA by AU-rich elements: key sequence features controlling mRNA deadenylation and decay.

    Nianhua Xu;Chyi-Ying A. Chen;Ann-Bin Shyu

  • CFIm25 links alternative polyadenylation to glioblastoma tumour suppression

    Chioniso P. Masamha;Zheng Xia;Jingxuan Yang;Todd R. Albrecht

  • mRNA decay mediated by two distinct AU-rich elements from c-fos and granulocyte-macrophage colony-stimulating factor transcripts: different deadenylation kinetics and uncoupling from translation.

    C.-Y. A. Chen;Nianhua Xu;Ann-Bin Shyu

  • Unraveling a cytoplasmic role for hnRNP D in the in vivo mRNA destabilization directed by the AU-rich element.

    Paul Loflin;Chyi-Ying A. Chen;Ann-Bin Shyu

  • Selective degradation of early-response-gene mRNAs: functional analyses of sequence features of the AU-rich elements.

    Chyi-Ying A Chen;Ann-Bin Shyu

  • A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex.

    Christophe Grosset;Chyi-Ying A Chen;Nianhua Xu;Nahum Sonenberg

  • Mechanisms of deadenylation-dependent decay.

    Chyi-Ying A. Chen;Ann-Bin Shyu

  • Messenger RNA half-life measurements in mammalian cells.

    Chyi Ying A. Chen;Nader Ezzeddine;Ann Bin Shyu

  • The Double Lives of Shuttling mRNA Binding Proteins

    Ann Bin Shyu;Miles F. Wilkinson

  • Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells

    Dinghai Zheng;Nader Ezzeddine;Chyi-Ying A. Chen;Wenmiao Zhu

  • Interplay of two functionally and structurally distinct domains of the c-fos AU-rich element specifies its mRNA-destabilizing function.

    Chyi-Ying A Chen;Tsuey Ming Chen;Ann-Bin Shyu

  • Ago-TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps.

    Chyi-Ying A Chen;Dinghai Zheng;Zhenfang Xia;Ann-Bin Shyu

Frequent Co-Authors

Michael E. Greenberg
Michael E. Greenberg Harvard University
Joel G. Belasco
Joel G. Belasco New York University
Miles F. Wilkinson
Miles F. Wilkinson University of California, San Diego
Leng Han
Leng Han Indiana University – Purdue University Indianapolis
Bertrand Séraphin
Bertrand Séraphin Institute of Genetics and Molecular and Cellular Biology
Kalle Gehring
Kalle Gehring McGill University
Cristiana Stellato
Cristiana Stellato University of Salerno
Gregory J. Hannon
Gregory J. Hannon University of Cambridge
Vincenzo Casolaro
Vincenzo Casolaro University of Salerno

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