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Genetics

D-Index
87
Citations
127431
World Ranking
1184
National Ranking
567

Overview

Alejandro A. Schäffer is affiliated with the National Institutes of Health in the United States. Their research portfolio spans multiple key areas, primarily within biochemistry, genetics, molecular biology, and medicine. The scientist's work engages deeply with molecular biology and oncology, with significant contributions in genetics and immunology as well.

Schäffer's main topics of study include cancer genomics and diagnostics, single-cell and spatial transcriptomics, cancer immunotherapy and biomarkers, CAR-T cell therapy research, as well as SARS-CoV-2 and COVID-19 research and clinical studies. Additionally, they have explored epigenetics and DNA methylation.

The scientist has published in a range of frequent venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Cancer Research
  • Nature Communications
  • Zenodo (CERN European Organization for Nuclear Research)

Notable recent papers authored or co-authored by Alejandro A. Schäffer include:

  • Large-Scale Study of Antibody Titer Decay following BNT162b2 mRNA Vaccine or SARS-CoV-2 Infection, 2021, Vaccines
  • Elapsed time since BNT162b2 vaccine and risk of SARS-CoV-2 infection: test negative design study, 2021, BMJ
  • Large-scale study of antibody titer decay following BNT162b2 mRNA vaccine or SARS-CoV-2 infection, 2021, bioRxiv (Cold Spring Harbor Laboratory)
  • The tumour microenvironment shapes innate lymphoid cells in patients with hepatocellular carcinoma, 2021, Gut
  • VADR: validation and annotation of virus sequence submissions to GenBank, 2020, BMC Bioinformatics

Frequent co-authors in Schäffer's collaborations include:

  • Eytan Ruppin
  • Sanju Sinha
  • E. Michael Gertz
  • Kenneth Aldape

Best Publications

  • Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.

    Stephen F. Altschul;Thomas L. Madden;Alejandro A. Schäffer;Jinghui Zhang

  • Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.

    Erik-Oliver Glocker;Daniel Kotlarz;Kaan Boztug;E. Michael Gertz

  • Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements

    Alejandro A. Schäffer;L. Aravind;Thomas L. Madden;Sergei Shavirin

  • Faster sequential genetic linkage computations.

    R W Cottingham;R M Idury;A A Schäffer

  • STAT3 Mutations in the Hyper-IgE Syndrome

    Steven M. Holland;Frank R. DeLeo;Houda Z. Elloumi;Amy P. Hsu

  • Database indexing for production MegaBLAST searches

    Aleksandr Morgulis;George Coulouris;Yan Raytselis;Thomas L. Madden

  • Protein database searches using compositionally adjusted substitution matrices

    Stephen F. Altschul;John C. Wootton;E. Michael Gertz;Richa Agarwala

  • Mapping of a Gene for Parkinson's Disease to Chromosome 4q21-q23

    Mihael H. Polymeropoulos;Joseph J. Higgins;Lawrence I. Golbe;William G. Johnson

  • A Homozygous CARD9 Mutation in a Family with Susceptibility to Fungal Infections

    Erik-Oliver Glocker;Andre Hennigs;Mohammad Nabavi;Alejandro A. Schäffer

  • Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations.

    Desireé Schubert;Desireé Schubert;Claudia Bode;Rupert Kenefeck;Tie Zheng Hou

  • Domain enhanced lookup time accelerated BLAST.

    Grzegorz M Boratyn;Alejandro A Schäffer;Richa Agarwala;Stephen F Altschul

  • Avoiding Recomputation in Linkage Analysis

    Alejandro A. Schäffer;Sandeep K. Gupta;K. Shriram;Robert W. Cottingham

  • Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans

    U Salzer;H M Chapel;A D B Webster;Q Pan-Hammarström

  • A Fast and Symmetric DUST Implementation to Mask Low-Complexity DNA Sequences

    Aleksandr Morgulis;E. Michael Gertz;Alejandro A. Schäffer;Richa Agarwala

  • Deleterious Mutations in LRBA Are Associated with a Syndrome of Immune Deficiency and Autoimmunity

    Gabriela Lopez-Herrera;Giacomo Tampella;Qiang Pan-Hammarström;Peer Herholz

  • HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease)

    Christoph Klein;Magda Grudzien;Giridharan Appaswamy;Manuela Germeshausen

  • A genetic linkage map of microsatellites in the domestic cat (Felis catus).

    Marilyn Menotti-Raymond;Victor A. David;Leslie A. Lyons;Alejandro A. Schäffer

  • Localization of a gene for an autosomal recessive form of juvenile Parkinsonism to chromosome 6q25.2-27

    H Matsumine;M Saito;S Shimoda-Matsubayashi;H Tanaka

  • Genetic Heterogeneity and Clonal Evolution Underlying Development of Asynchronous Metastasis in Human Breast Cancer

    Tuula Kuukasjärvi;Ritva Karhu;Minna Tanner;Marketta Kähkönen

  • Genetic Linkage of Hyper-IgE Syndrome to Chromosome 4

    Bodo Grimbacher;Alejandro A. Schäffer;Steven M. Holland;Joie Davis

Frequent Co-Authors

Bodo Grimbacher
Bodo Grimbacher University of Freiburg
Thomas Ried
Thomas Ried National Institutes of Health
Dietmar Pfeifer
Dietmar Pfeifer University of Freiburg
Eytan Ruppin
Eytan Ruppin National Institutes of Health
Ulrich Salzer
Ulrich Salzer University of Freiburg
Stephen J. O'Brien
Stephen J. O'Brien Nova Southeastern University
Leslie G. Biesecker
Leslie G. Biesecker National Institutes of Health
Alan R. Shuldiner
Alan R. Shuldiner University of Maryland, Baltimore
William J. Murphy
William J. Murphy Texas A&M University
Nima Rezaei
Nima Rezaei Tehran University of Medical Sciences

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