World's Best Scientists 2026 revealed!

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Immunology

D-Index
70
Citations
14999
World Ranking
2442
National Ranking
1167

Overview

Yuri Persidsky is affiliated with Temple University in the United States and has contributed extensively to research in biochemistry, genetics, molecular biology, neuroscience, immunology, and microbiology. Their work spans 24 publications in these combined fields, with significant interdisciplinary focus on neurology, immunology, molecular biology, physiology, and biochemistry.

Their research covers several main scientific topics, including studies on barrier structure and function, mechanisms of neuroinflammation and neurodegeneration, the role of extracellular vesicles in disease processes, adenosine and purinergic signaling, immune cell function and interaction, and sulfur compounds in biology.

Persidsky has published numerous papers in recognized scientific venues. Among the recent publications are:

  • "Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood-brain barrier" (2020, Proceedings of the National Academy of Sciences)
  • "Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles" (2020, Scientific Reports)
  • "Electronic cigarette exposure disrupts blood-brain barrier integrity and promotes neuroinflammation" (2020, Brain Behavior and Immunity)
  • "let-7g counteracts endothelial dysfunction and ameliorating neurological functions in mouse ischemia/reperfusion stroke model" (2020, Brain Behavior and Immunity)
  • "Blocking of P2X7r Reduces Mitochondrial Stress Induced by Alcohol and Electronic Cigarette Exposure in Brain Microvascular Endothelial Cells" (2022, Antioxidants)

Their work is also frequently published in journals such as HLA, Scientific Reports, Brain Behavior and Immunity, American Journal of Pathology, and the International Journal of Molecular Sciences. These publication venues reflect their engagement with both foundational immunological research and clinical neuroscience.

Yuri Persidsky collaborates regularly with several co-authors, including Slava Rom, Alecia Seliga, Nancy L. Reichenbach, Nathan A. Heldt, and Sachin Gajghate. These collaborations indicate an active research network largely centered around neurobiology, immunology, and molecular mechanisms involved in brain barrier function and inflammation.

Best Publications

  • Blood-brain barrier: structural components and function under physiologic and pathologic conditions

    Yuri Persidsky;Servio H. Ramirez;James Haorah;Georgette D. Kanmogne

  • Mechanism of alcohol-induced oxidative stress and neuronal injury

    James Haorah;Servio H. Ramirez;Nicholas Floreani;Santhi Gorantla

  • A Model for Monocyte Migration Through the Blood-Brain Barrier during HIV-1 Encephalitis

    Yuri Persidsky;Monique Stins;Dennis Way;Marlys H. Witte

  • Microglial and astrocyte chemokines regulate monocyte migration through the blood-brain barrier in human immunodeficiency virus-1 encephalitis.

    Yuri Persidsky;Anuja Ghorpade;Jennifer Rasmussen;Jenae Limoges

  • Intracellular CXCR4 signaling, neuronal apoptosis and neuropathogenic mechanisms of HIV-1-associated dementia.

    Jialin Charlie Zheng;Michael R Thylin;Anuja Ghorpade;Huangui Xiong

  • Alcohol-induced oxidative stress in brain endothelial cells causes blood-brain barrier dysfunction

    J. Haorah;B. Knipe;J. Leibhart;A. Ghorpade

  • Matrix Metalloproteinase-2 Production and Its Binding to the Matrix Are Increased in Abdominal Aortic Aneurysms

    V Davis;R Persidskaia;L Baca-Regen;Y Itoh

  • Hyperglycemia-Driven Neuroinflammation Compromises BBB Leading to Memory Loss in Both Diabetes Mellitus (DM) Type 1 and Type 2 Mouse Models

    Unknown

  • Phosphorylation of Claudin-5 and Occludin by Rho Kinase in Brain Endothelial Cells

    Masaru Yamamoto;Servio H. Ramirez;Shinji Sato;Tomomi Kiyota

  • Activation of Cannabinoid Receptor 2 Attenuates Leukocyte–Endothelial Cell Interactions and Blood–Brain Barrier Dysfunction under Inflammatory Conditions

    Servio H. Ramirez;János Haskó;Andrew Skuba;Shongshan Fan

  • Cannabinoid receptor 2: potential role in immunomodulation and neuroinflammation.

    Slava Rom;Yuri Persidsky

  • Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE).

    Yuri Persidsky;David Heilman;David Heilman;James Haorah;James Haorah;Marina Zelivyanskaya;Marina Zelivyanskaya

  • HIV-1 gp120 compromises blood-brain barrier integrity and enhance monocyte migration across blood-brain barrier: implication for viral neuropathogenesis

    Georgette D Kanmogne;Kathy Schall;Jessica Leibhart;Bryan Knipe

  • Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier

    Michael J Bernas;Filipa L Cardoso;Sarah K Daley;Martin E Weinand

  • Blocking TNF-α Attenuates Aneurysm Formation in a Murine Model

    Wanfen Xiong;Jason MacTaggart;Rebecca Knispel;Jennifer Worth

  • Methamphetamine disrupts blood–brain barrier function by induction of oxidative stress in brain endothelial cells

    Servio H Ramirez;Raghava Potula;Shongshan Fan;Tess Eidem

  • Mononuclear phagocyte immunity and the neuropathogenesis of HIV-1 infection.

    Yuri Persidsky;Howard E. Gendelman

  • Suppression of Inflammatory Neurotoxins by Highly Active Antiretroviral Therapy in Human Immunodeficiency Virus—Associated Dementia

    Howard Eliot Gendelman;Jialin C Zheng;Cynthia L. Coulter;Anuja Ghorpade

  • Mononuclear phagocytes mediate blood-brain barrier compromise and neuronal injury during HIV-1-associated dementia

    Yuri Persidsky;Jialin Zheng;Donald Miller;Howard E. Gendelman

  • Role of the β-Chemokine Receptors CCR3 and CCR5 in Human Immunodeficiency Virus Type 1 Infection of Monocytes and Microglia

    Anuja Ghorpade;Meng Q.I. Xia;Bradley T. Hyman;Yuri Persidsky

  • Inhibition of indoleamine 2,3-dioxygenase (IDO) enhances elimination of virus-infected macrophages in an animal model of HIV-1 encephalitis.

    Raghava Potula;Larisa Poluektova;Larisa Poluektova;Larisa Poluektova;Bryan Knipe;Bryan Knipe;Bryan Knipe;Jesse Chrastil;Jesse Chrastil;Jesse Chrastil

  • Infections of the nervous system.

    Howard Eliot Gendelman;Yuri Persidsky

Frequent Co-Authors

Howard E. Gendelman
Howard E. Gendelman University of Nebraska Medical Center
Wen-Zhe Ho
Wen-Zhe Ho Temple University
Jialin C. Zheng
Jialin C. Zheng Tongji University
Larisa Y. Poluektova
Larisa Y. Poluektova University of Nebraska Medical Center
David H. Munn
David H. Munn Augusta University
Tsuneya Ikezu
Tsuneya Ikezu Boston University
Jonathan Kipnis
Jonathan Kipnis Washington University in St. Louis
Howard S. Fox
Howard S. Fox University of Nebraska Medical Center
Kwang Sik Kim
Kwang Sik Kim Johns Hopkins University School of Medicine
Monique F. Stins
Monique F. Stins Johns Hopkins University

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