World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
48
Citations
11476
World Ranking
18257
National Ranking
7461

Overview

Sam John is affiliated with the National Institutes of Health in the United States and has contributed extensively to research in Medicine and Immunology and Microbiology, with a total of 26 publications in Medicine and 15 in Immunology and Microbiology. Their work spans several subfields, including Immunology, Oncology, Pathology and Forensic Medicine, Pulmonary and Respiratory Medicine, and Genetics.

The scientist's research focuses on various key topics, such as Immune Cell Function and Interaction, Vitamin D Research Studies, Cancer Immunotherapy and Biomarkers, T-cell and B-cell Immunology, Vasculitis and related conditions, Inflammatory Bowel Disease, and Adrenal Hormones and Disorders.

Sam John has published articles in multiple reputed venues, frequently contributing to bioRxiv (Cold Spring Harbor Laboratory), Gastroenterology, The Journal of Immunology, Nature Immunology, and The Journal of Experimental Medicine. Notable papers include:

  • Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells (2021, Nature Immunology)
  • Immunogenomics of Colorectal Cancer Response to Checkpoint Blockade: Analysis of the KEYNOTE 177 Trial and Validation Cohorts (2021, Gastroenterology)
  • Human marginal zone B cell development from early T2 progenitors (2020, The Journal of Experimental Medicine)
  • CD1d-dependent rewiring of lipid metabolism in macrophages regulates innate immune responses (2022, Nature Communications)
  • An autocrine Vitamin D-driven Th1 shutdown program can be exploited for COVID-19 (2020, bioRxiv [Cold Spring Harbor Laboratory])

Throughout their research career, Sam John has collaborated with various co-authors, including David D'Cruz, Paul Lavender, Jo Spencer, Daniel Chauss, and Tilo Freiwald. These collaborations have contributed to advancing knowledge in immunology and related biomedical fields.

Best Publications

  • Chromatin accessibility pre-determines glucocorticoid receptor binding patterns

    Sam John;Peter J. Sabo;Robert E. Thurman;Myong Hee Sung

  • Replication fork stability confers chemoresistance in BRCA-deficient cells

    Arnab Ray Chaudhuri;Elsa Callen;Xia Ding;Ewa Gogola

  • Transcriptional activators direct histone acetyltransferase complexes to nucleosomes

    Rhea T. Utley;Keiko Ikeda;Patrick A. Grant;Jacques Côté

  • Transcription Factor AP1 Potentiates Chromatin Accessibility and Glucocorticoid Receptor Binding

    Simon C. Biddie;Sam John;Pete J. Sabo;Robert E. Thurman

  • Expanded lysine acetylation specificity of Gcn5 in native complexes.

    Patrick A. Grant;Anton Eberharter;Sam John;Richard G. Cook

  • Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcription

    Diana A. Stavreva;Malgorzata Wiench;Sam John;Becky L. Conway-Campbell

  • Extensive chromatin remodelling and establishment of transcription factor 'hotspots' during early adipogenesis

    Rasmus Siersbæk;Ronni Nielsen;Sam John;Myong-Hee Sung

  • Interaction of the glucocorticoid receptor with the chromatin landscape.

    Sam John;Peter J. Sabo;Thomas A. Johnson;Myong Hee Sung

  • Dynamic Exchange at Regulatory Elements during Chromatin Remodeling Underlies Assisted Loading Mechanism

    Ty C. Voss;R. Louis Schiltz;Myong Hee Sung;Paul M. Yen

  • Actin-dependent intranuclear repositioning of an active gene locus in vivo

    Miroslav Dundr;Jason K. Ospina;Myong Hee Sung;Sam John

  • The Something About Silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAFII30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)–FACT complex

    Sam John;LeAnn Howe;Stefan T. Tafrov;Patrick A. Grant

  • Histone H3 specific acetyltransferases are essential for cell cycle progression

    LeAnn Howe;Darryl Auston;Patrick Grant;Sam John

  • DNA methylation status predicts cell type-specific enhancer activity

    Malgorzata Wiench;Sam John;Songjoon Baek;Thomas A. Johnson

  • C/EBP maintains chromatin accessibility in liver and facilitates glucocorticoid receptor recruitment to steroid response elements

    Lars Grøntved;Sam John;Songjoon Baek;Ying Liu

  • Dynamic behavior of transcription factors on a natural promoter in living cells.

    Matthias Becker;Christopher Baumann;Sam John;Dawn A. Walker

  • Nucleosome positioning on the MMTV LTR results from the frequency-biased occupancy of multiple frames.

    G Fragoso;S John;M S Roberts;G L Hager

  • HDAC1 Acetylation Is Linked to Progressive Modulation of Steroid Receptor-Induced Gene Transcription

    Yi Qiu;Yingming Zhao;Matthias Becker;Sam John

  • Purified histone acetyltransferase complexes stimulate HIV-1 transcription from preassembled nucleosomal arrays

    David J. Steger;Anton Eberharter;Sam John;Patrick A. Grant

  • Diverse gene reprogramming events occur in the same spatial clusters of distal regulatory elements.

    Ofir Hakim;Myong Hee Sung;Ty C. Voss;Erik Splinter

  • Overlapping chromatin-remodeling systems collaborate genome wide at dynamic chromatin transitions

    Stephanie A Morris;Songjoon Baek;Myong-Hee Sung;Sam John

Frequent Co-Authors

Gordon L. Hager
Gordon L. Hager National Institutes of Health
Jerry L. Workman
Jerry L. Workman Stowers Institute for Medical Research
John A. Stamatoyannopoulos
John A. Stamatoyannopoulos University of Washington
Patrick A. Grant
Patrick A. Grant University of Virginia
André Nussenzweig
André Nussenzweig National Institutes of Health
David J. Steger
David J. Steger University of Pennsylvania
Sven Rottenberg
Sven Rottenberg University of Bern
Tom Owen-Hughes
Tom Owen-Hughes University of Dundee
Charles Vinson
Charles Vinson National Institutes of Health
Thomas Ried
Thomas Ried National Institutes of Health

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