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Biology and Biochemistry

D-Index
61
Citations
25552
World Ranking
11098
National Ranking
4801

Overview

Ronald A. Milligan is affiliated with the Scripps Research Institute in the United States. Their research spans several interconnected fields within the biological sciences, focusing primarily on Biochemistry, Genetics, and Molecular Biology.

The scientist's work covers a number of subfields including Cell Biology, Molecular Biology, Genetics, and Structural Biology. This diverse scope is reflected in the main research topics addressed throughout their publications:

  • Microtubule and mitosis dynamics
  • Hedgehog Signaling Pathway Studies
  • Genetic and Kidney Cyst Diseases
  • Cellular Mechanics and Interactions
  • Advanced Electron Microscopy Techniques and Applications

Milligan has contributed papers to various respected publication venues with a presence in:

  • eLife
  • Nature Cell Biology
  • bioRxiv (Cold Spring Harbor Laboratory)

Notable recent papers include:

  • The kinesin-5 tail domain directly modulates the mechanochemical cycle of the motor domain for anti-parallel microtubule sliding, 2020, eLife
  • Cytoskeletal regulation of a transcription factor by DNA mimicry, 2021, bioRxiv (Cold Spring Harbor Laboratory)
  • Cytoskeletal regulation of a transcription factor by DNA mimicry via coiled-coil interactions, 2022, Nature Cell Biology

Frequent co-authors collaborating with Milligan are:

  • Elizabeth M. Wilson-Kubalek
  • Farah Haque
  • Christian Freniere
  • Qiong Ye
  • Nandini Mani

These collaborations demonstrate an interdisciplinary approach, integrating expertise from various researchers contributing to the complex topics studied.

Milligan's work is primarily concerned with understanding molecular and cellular mechanisms that regulate microtubule behavior, transcription factor interactions, and signaling pathways relevant to cellular and genetic functions. Such research contributes to broader knowledge in cell mechanics, signaling pathways, and genetic disease mechanisms without focusing on clinical applications.

Best Publications

  • Structure of the actin-myosin complex and its implications for muscle contraction.

    Ivan Rayment;Hazel M. Holden;Michael Whittaker;Christopher B. Yohn

  • Self-assembling organic nanotubes based on a cyclic peptide architecture

    M. Reza Ghadiri;Juan R. Granja;Ronald A. Milligan;Duncan E. McRee

  • The Way Things Move: Looking Under the Hood of Molecular Motor Proteins

    Ronald D. Vale;Ronald A. Milligan

  • High-resolution model of the microtubule.

    Eva Nogales;Eva Nogales;Michael Whittaker;Ronald A. Milligan;Kenneth H. Downing

  • A structural change in the kinesin motor protein that drives motility

    Sarah Rice;Abel W. Lin;Daniel Safer;Cynthia L. Hart

  • Myosin VI is an actin-based motor that moves backwards

    Wells Al;Lin Aw;Chen Lq;Safer D

  • Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells.

    Piotr Kazmierczak;Hirofumi Sakaguchi;Joshua Tokita;Elizabeth M. Wilson-Kubalek

  • Microtubule dynamics and microtubule caps: a time-resolved cryo-electron microscopy study

    E.M. Mandelkow;E. Mandelkow;R.A. Milligan

  • Situs: A package for docking crystal structures into low-resolution maps from electron microscopy.

    W Wriggers;R A Milligan;J A McCammon

  • Architecture and design of the nuclear pore complex.

    Jenny E. Hinshaw;Bridget O. Carragher;Ronald A. Milligan

  • Molecular structure of F-actin and location of surface binding sites.

    R. A. Milligan;M. Whittaker;D. Safer

  • Supramolecular Architecture of Severe Acute Respiratory Syndrome Coronavirus Revealed by Electron Cryomicroscopy

    Benjamin W. Neuman;Brian D. Adair;Craig Yoshioka;Joel D. Quispe

  • A 35-Å movement of smooth muscle myosin on ADP release

    M Whittaker;E M Wilson-Kubalek;J E Smith;L Faust

  • Kinesin follows the microtubule's protofilament axis.

    Sanghamitra Ray;Edgar Meyhöfer;Ronald A. Milligan;Jonathon Howard

  • MAP2 and tau bind longitudinally along the outer ridges of microtubule protofilaments

    Jawdat Al-Bassam;Rachel S. Ozer;Daniel Safer;Shelley Halpain

  • Insights into antiparallel microtubule crosslinking by PRC1, a conserved nonmotor microtubule binding protein.

    Radhika Subramanian;Elizabeth M. Wilson-Kubalek;Christopher P. Arthur;Matthew J. Bick

  • A large particle associated with the perimeter of the nuclear pore complex.

    P N Unwin;R A Milligan

  • The motor protein myosin-I produces its working stroke in two steps

    Claudia Veigel;Lynne M. Coluccio;James D. Jontes;John C. Sparrow

  • Leginon: An Automated System for Acquisition of Images from Vitreous Ice Specimens

    Bridget Carragher;Nick Kisseberth;David Kriegman;Ronald A. Milligan

  • Characterization of Two Related Drosophila γ-tubulin Complexes that Differ in Their Ability to Nucleate Microtubules

    Karen Oegema;Christiane Wiese;Ona C. Martin;Ronald A. Milligan

Frequent Co-Authors

Ronald D. Vale
Ronald D. Vale University of California, San Francisco
Andrew B. Ward
Andrew B. Ward Scripps Research Institute
Mark Yeager
Mark Yeager University of Miami
Tarun M. Kapoor
Tarun M. Kapoor Rockefeller University
Thomas D. Pollard
Thomas D. Pollard Yale University
Fred Dyda
Fred Dyda National Institutes of Health
Robert J. Fletterick
Robert J. Fletterick University of California, San Francisco
Michael J. Buchmeier
Michael J. Buchmeier University of California, Irvine

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