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Biology and Biochemistry

D-Index
86
Citations
26116
World Ranking
2970
National Ranking
1520

Overview

Robert F. Margolskee is affiliated with the Monell Chemical Senses Center in the United States. Their research primarily spans the fields of Nursing and Neuroscience, with a particular focus on Nutrition and Dietetics, Sensory Systems, Biomedical Engineering, Molecular Biology, and Immunology. This diverse scope reflects a multidisciplinary approach to understanding sensory and biochemical processes.

Their work covers several main topics, including Biochemical Analysis and Sensing Techniques, Olfactory and Sensory Function Studies, Advanced Chemical Sensor Technologies, RNA and protein synthesis mechanisms, Regulation of Appetite and Obesity, Immune Cell Function and Interaction, and IL-33, ST2, and ILC Pathways.

Robert F. Margolskee's recent publications demonstrate active engagement with research on sensory biology and immune responses. Notable papers include:

  • Up-regulation of gasdermin C in mouse small intestine is associated with lytic cell death in enterocytes in worm-induced type 2 immunity, 2021, Proceedings of the National Academy of Sciences
  • Sodium-glucose cotransporter 1 as a sugar taste sensor in mouse tongue, 2020, Acta Physiologica
  • Injury-induced pulmonary tuft cells are heterogenous, arise independent of key Type 2 cytokines, and are dispensable for dysplastic repair, 2022, eLife
  • Lipopolysaccharide-Induced Inflammatory Cytokine Expression in Taste Organoids, 2020, Chemical Senses
  • Evidence that human oral glucose detection involves a sweet taste pathway and a glucose transporter pathway, 2021, PLoS ONE

Frequent co-authors collaborating with Margolskee include Peihua Jiang, Ichiro Matsumoto, Hong Wang, Minliang Zhou, and Ranhui Xi. This network of collaborators suggests integration across multiple research groups and complementary expertise.

Publication venues frequently featuring Margolskee's work include bioRxiv (Cold Spring Harbor Laboratory), Proceedings of the National Academy of Sciences, eLife, Chemical Senses, and Stem Cell Reports. These venues cover a broad range of scientific disciplines related to sensory science and molecular biology.

Best Publications

  • Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1

    Hyeung-Jin Jang;Zaza Kokrashvili;Michael J. Theodorakis;Olga D. Carlson

  • T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1

    Robert F. Margolskee;Jane Dyer;Zaza Kokrashvili;Kieron S. H. Salmon

  • Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut

    Michael R. Howitt;Sydney Lavoie;Monia Michaud;Arthur M. Blum

  • Transduction of bitter and sweet taste by gustducin

    Gwendolyn T. Wong;Kimberley S. Gannon;Robert F. Margolskee

  • Gustducin is a taste-cell-specific G protein closely related to the transducins

    Susan K. McLaughlin;Peter J. McKinnon;Robert F. Margolskee

  • Detection of Sweet and Umami Taste in the Absence of Taste Receptor T1r3

    Sami Damak;Minqing Rong;Keiko Yasumatsu;Zaza Kokrashvili

  • Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac.

    Marianna Max;Y. Gopi Shanker;Liquan Huang;Minqing Rong

  • Trp8, a transient receptor potential channel expressed in taste receptor cells

    Robert F Margolskee;Liquan Huang;Minqing Rong;Marianna Max

  • Heat activation of TRPM5 underlies thermal sensitivity of sweet taste

    Karel Talavera;Keiko Yasumatsu;Thomas Voets;Guy Droogmans

  • Molecular mechanisms of bitter and sweet taste transduction.

    Robert F. Margolskee

  • Bitter and sweet taste receptors regulate human upper respiratory innate immunity

    Robert J. Lee;Jennifer M. Kofonow;Philip L. Rosen;Adam P. Siebert

  • Phototransduction in transgenic mice after targeted deletion of the rod transducin α-subunit

    P. D. Calvert;N. V. Krasnoperova;A. L. Lyubarsky;A. L. Lyubarsky;T. Isayama

  • Mechanisms of taste transduction.

    Sue C Kinnamon;Sue C Kinnamon;Robert F Margolskee;Robert F Margolskee;Robert F Margolskee

  • Ggamma13 colocalizes with gustducin in taste receptor cells and mediates IP3 responses to bitter denatonium.

    L Huang;Y G Shanker;J Dubauskaite;J Z Zheng;J Z Zheng

  • HLA class I-restricted human cytotoxic T cells recognize endogenously synthesized hepatitis B virus nucleocapsid antigen.

    Antonio Bertoletti;Carlo Ferrari;Franco Fiaccadori;Amalia Penna

  • Afferent neurotransmission mediated by hemichannels in mammalian taste cells

    Roman A Romanov;Olga A Rogachevskaja;Marina F Bystrova;Peihua Jiang

  • The molecular physiology of taste transduction

    Timothy A Gilbertson;Sami Damak;Robert F Margolskee

  • Mouse taste cells with G protein-coupled taste receptors lack voltage-gated calcium channels and SNAP-25

    Tod R Clapp;Kathryn F Medler;Kathryn F Medler;Sami Damak;Sami Damak;Robert F Margolskee

  • Immunocytochemical evidence for co-expression of Type III IP3 receptor with signaling components of bitter taste transduction.

    Tod R Clapp;Leslie M Stone;Robert F Margolskee;Sue C Kinnamon

  • Lactisole Interacts with the Transmembrane Domains of Human T1R3 to Inhibit Sweet Taste

    Peihua Jiang;Meng Cui;Baohua Zhao;Zhan Liu

Frequent Co-Authors

Yuzo Ninomiya
Yuzo Ninomiya Kyushu University
Ryusuke Yoshida
Ryusuke Yoshida Okayama University
Sue C. Kinnamon
Sue C. Kinnamon University of Colorado Anschutz Medical Campus
Yuchio Yanagawa
Yuchio Yanagawa Gunma University
Harel Weinstein
Harel Weinstein Cornell University
Noam A. Cohen
Noam A. Cohen University of Pennsylvania
Kunihiko Obata
Kunihiko Obata The Graduate University for Advanced Studies, SOKENDAI
Bernd Nilius
Bernd Nilius KU Leuven
Thomas Voets
Thomas Voets KU Leuven
Daniel Nathans
Daniel Nathans Johns Hopkins University

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