World's Best Scientists 2026 revealed!

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Medicine

D-Index
110
Citations
44619
World Ranking
5565
National Ranking
18

Overview

Patrick Tan is affiliated with Duke NUS Graduate Medical School in Singapore, with a strong research focus spanning biochemistry, genetics, molecular biology, and medicine. Their work importantly contributes to molecular biology and oncology fields, particularly related to cancer research and genetics.

The scientist's research addresses topics such as epigenetics and DNA methylation, RNA modifications and cancer, cancer-related gene regulation, cancer genomics and diagnostics, gastric cancer management and outcomes, cancer cells and metastasis, and cancer-related molecular mechanisms research.

Frequent publication venues for their work include bioRxiv (Cold Spring Harbor Laboratory), OPAL (Open@LaTrobe) from La Trobe University, Gut, Cancer Research, and Nature Communications.

Patrick Tan has several recent papers published in high-impact journals, including:

  • Single-Cell Atlas of Lineage States, Tumor Microenvironment, and Subtype-Specific Expression Programs in Gastric Cancer (2021, Cancer Discovery)
  • Enabling Technologies for Personalized and Precision Medicine (2020, Trends in Biotechnology)
  • Genomic Basis for RNA Alterations in Cancer (2020, Nature)
  • A Global Catalog of Whole-Genome Diversity from 233 Primate Species (2023, Science)
  • AQP5 Enriches for Stem Cells and Cancer Origins in the Distal Stomach (2020, Nature)

The scientist frequently collaborates with other researchers, most notably with Xuewen Ong, Angie Lay Keng Tan, Shamaine Wei Ting Ho, Supriya Srivastava, and Raghav Sundar, reflecting a collaborative approach in their research endeavors.

Best Publications

  • Pan-cancer analysis of whole genomes

    Peter J. Campbell;Gad Getz;Jan O. Korbel;Joshua M. Stuart

  • Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes

    Razvan Cristescu;Jeeyun Lee;Michael Nebozhyn;Kyoung-Mee Kim

  • Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer

    Sooryanarayana Varambally;Qi Cao;Ram Shankar Mani;Sunita Shankar

  • Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

    Jing Tan;Xiaojing Yang;Li Zhuang;Xia Jiang

  • Whole-Genome and Epigenomic Landscapes of Etiologically Distinct Subtypes of Cholangiocarcinoma

    Apinya Jusakul;Apinya Jusakul;Ioana Cutcutache;Chern Han Yong;Jing Quan Lim

  • A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets

    Niantao Deng;Liang Kee Goh;Hannah Wang;Kakoli Das

  • Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes

    Zhi Jiang Zang;Ioana Cutcutache;Song Ling Poon;Shen Li Zhang

  • A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer.

    King Pan Ng;Axel M Hillmer;Charles T H Chuah;Charles T H Chuah;Wen Chun Juan

  • Complications of cholecystectomy: risks of the laparoscopic approach and protective effects of operative cholangiography: a population-based study.

    David R. Fletcher;Michael S.T. Hobbs;Patrick Tan;Liora J. Valinsky

  • Rearrangements of the RAF Kinase Pathway in Prostate Cancer, Gastric Cancer and Melanoma

    Nallasivam Palanisamy;Bushra Ateeq;Shanker Kalyana-Sundaram;Dorothee Pflueger;Dorothee Pflueger

  • Exome sequencing of liver fluke–associated cholangiocarcinoma

    Choon Kiat Ong;Chutima Subimerb;Chutima Subimerb;Chawalit Pairojkul;Sopit Wongkham

  • Exome sequencing identifies distinct mutational patterns in liver fluke–related and non-infection-related bile duct cancers

    Waraporn Chan-on;Waraporn Chan-on;Maarja-Liisa Nairismägi;Choon Kiat Ong;Weng Khong Lim

  • Profiling MicroRNA Expression in Hepatocellular Carcinoma Reveals MicroRNA-224 Up-regulation and Apoptosis Inhibitor-5 as a MicroRNA-224-specific Target

    Yu Wang;Alvin T.C. Lee;Joel Z.I. Ma;Jingbo Wang

  • Identification of Molecular Subtypes of Gastric Cancer With Different Responses to PI3-Kinase Inhibitors and 5-Fluorouracil

    Zhengdeng Lei;Iain Beehuat Tan;Kakoli Das;Niantao Deng

  • Genetics and Molecular Pathogenesis of Gastric Adenocarcinoma.

    Patrick Tan;Khay-Guan Yeoh;Khay-Guan Yeoh

  • Oncogenic Pathway Combinations Predict Clinical Prognosis in Gastric Cancer

    Chia Huey Ooi;Tatiana Ivanova;Jeanie Wu;Minghui Lee

  • Intrinsic subtypes of gastric cancer, based on gene expression pattern, predict survival and respond differently to chemotherapy

    Iain Beehuat Tan;Tatiana Ivanova;Kiat Hon Lim;Chee Wee Ong

  • Paradoxical relationship between chromosomal instability and survival outcome in cancer.

    Nicolai J. Birkbak;Aron C. Eklund;Qiyuan Li;Qiyuan Li;Sarah E. McClelland

  • Integrative Analysis of Head and Neck Cancer Identifies Two Biologically Distinct HPV and Three Non-HPV Subtypes

    Michaela K. Keck;Michaela K. Keck;Zhixiang Zuo;Arun Khattri;Thomas P. Stricker

  • Genetic algorithms applied to multi-class prediction for the analysis of gene expression data.

    Chia Huey Ooi;Patrick Tan

Frequent Co-Authors

Bin Tean Teh
Bin Tean Teh National University of Singapore
Steve Rozen
Steve Rozen National University of Singapore
Sun Young Rha
Sun Young Rha Yonsei University
Wing-Kin Sung
Wing-Kin Sung Chinese University of Hong Kong
Alex Boussioutas
Alex Boussioutas University of Melbourne
Axel M. Hillmer
Axel M. Hillmer University of Cologne
Puay Hoon Tan
Puay Hoon Tan Duke NUS Graduate Medical School
Manuel Salto-Tellez
Manuel Salto-Tellez Queen's University Belfast
Henry Yang
Henry Yang National University of Singapore
Yijun Ruan
Yijun Ruan University of Connecticut Health Center

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