World's Best Scientists 2026 revealed!

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Genetics

D-Index
83
Citations
66404
World Ranking
1382
National Ranking
654

Overview

Yijun Ruan is affiliated with the University of Connecticut Health Center in the United States and has a research focus primarily in biochemistry, genetics, and molecular biology.

The scientist has an extensive publication record, with 84 works in the field of biochemistry, genetics, and molecular biology. Subfields of study include molecular biology, genetics, immunology, plant science, and cancer research.

Yijun Ruan's research covers various topics, notably genomics and chromatin dynamics, RNA research and splicing, epigenetics and DNA methylation, RNA and protein synthesis mechanisms, chromosomal and genetic variations, genomic variations and chromosomal abnormalities, and single-cell and spatial transcriptomics.

Their recent papers include:

  • Oncogenic extrachromosomal DNA functions as mobile enhancers to globally amplify chromosomal transcription (2021, Cancer Cell)
  • A supervised learning framework for chromatin loop detection in genome-wide contact maps (2020, Nature Communications)
  • Multidimensional single-cell analysis of human peripheral blood reveals characteristic features of the immune system landscape in aging and frailty (2022, Nature Aging)
  • Spatial and temporal organization of the genome: Current state and future aims of the 4D nucleome project (2023, Molecular Cell)
  • Graph embedding and unsupervised learning predict genomic sub-compartments from HiC chromatin interaction data (2020, Nature Communications)

Frequent co-authors of Yijun Ruan include:

  • Dariusz Plewczyński
  • Byoungkoo Lee
  • Xiaoan Ruan
  • Minji Kim
  • Chia-Lin Wei

The scientist has published extensively in several venues, with the most frequent being ENCODE Datasets, Nature Communications, bioRxiv (Cold Spring Harbor Laboratory), Science Advances, and Scientific Reports.

Best Publications

  • Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

    Ewan Birney;John A. Stamatoyannopoulos;Anindya Dutta;Roderic Guigó

  • Landscape of transcription in human cells

    Sarah Djebali;Carrie A. Davis;Angelika Merkel;Alex Dobin

  • The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression.

    Thomas Derrien;Rory Johnson;Giovanni Bussotti;Andrea Tanzer

  • The Transcriptional Landscape of the Mammalian Genome

    P. Carninci;T. Kasukawa;S. Katayama;J. Gough

  • Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells

    Xi Chen;Han Xu;Ping Yuan;Fang Fang;Fang Fang

  • The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells.

    Yuin Han Loh;Qiang Wu;Joon Lin Chew;Joon Lin Chew;Vinsensius B. Vega

  • An integrated encyclopedia of DNA elements in the human genome

    Ian Dunham;Anshul Kundaje;Shelley F. Aldred;Patrick J. Collins

  • International network of cancer genome projects

    Thomas J. Hudson;Thomas J. Hudson;Warwick Anderson;Axel Aretz;Anna D. Barker

  • An oestrogen-receptor-α-bound human chromatin interactome

    Melissa J. Fullwood;Mei Hui Liu;You Fu Pan;Jun Liu

  • A User's Guide to the Encyclopedia of DNA Elements (ENCODE)

    Richard M. Myers;John Stamatoyannopoulos;Michael Snyder;Ian Dunham

  • A global map of p53 transcription-factor binding sites in the human genome.

    Chia-Lin Wei;Qiang Wu;Vinsensius B. Vega;Kuo Ping Chiu

  • Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation.

    Guoliang Li;Xiaoan Ruan;Raymond K. Auerbach;Kuljeet Singh Sandhu

  • The draft genome of sweet orange (Citrus sinensis).

    Qiang Xu;Ling Ling Chen;Xiaoan Ruan;Dijun Chen

  • Functional metagenomic profiling of nine biomes

    Elizabeth A. Dinsdale;Robert A. Edwards;Dana Hall;Florent Angly

  • CTCF-Mediated Human 3D Genome Architecture Reveals Chromatin Topology for Transcription.

    Zhonghui Tang;Oscar Junhong Luo;Xingwang Li;Meizhen Zheng

  • RNA Viral Community in Human Feces: Prevalence of Plant Pathogenic Viruses

    Tao Zhang;Mya Breitbart;Wah Heng Lee;Jin-Quan Run

  • Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells

    Stefan Schoenfelder;Tom Sexton;Lyubomira Chakalova;Nathan F Cope

  • CTCF-mediated functional chromatin interactome in pluripotent cells

    Lusy Handoko;Han Xu;Guoliang Li;Chew Yee Ngan

  • Comparative full-length genome sequence analysis of 14 SARS coronavirus isolates and common mutations associated with putative origins of infection

    Yijun Ruan;Chia Lin Wei;Ai Ee Ling;Vinsensius B Vega

  • Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes

    Zhi Jiang Zang;Ioana Cutcutache;Song Ling Poon;Shen Li Zhang

Frequent Co-Authors

Chia-Lin Wei
Chia-Lin Wei Lawrence Berkeley National Laboratory
Wing-Kin Sung
Wing-Kin Sung Chinese University of Hong Kong
Edison T. Liu
Edison T. Liu The Jackson Laboratory
Axel M. Hillmer
Axel M. Hillmer University of Cologne
Patrick Tan
Patrick Tan Duke NUS Graduate Medical School
Guillaume Bourque
Guillaume Bourque McGill University
Huck-Hui Ng
Huck-Hui Ng Genome Institute of Singapore
Thomas R. Gingeras
Thomas R. Gingeras Cold Spring Harbor Laboratory
Mark Gerstein
Mark Gerstein Yale University
Niranjan Nagarajan
Niranjan Nagarajan Genome Institute of Singapore

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