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Biology and Biochemistry

D-Index
55
Citations
10450
World Ranking
15099
National Ranking
533

Overview

Michael Butler is affiliated with the University of Manitoba in Canada. Their research spans multiple fields with a primary focus on Biochemistry, Genetics and Molecular Biology as well as Medicine.

The main subfields of study covered in their work include:

  • Molecular Biology
  • Biomedical Engineering
  • Radiology, Nuclear Medicine and Imaging
  • Infectious Diseases
  • Biotechnology

Their research topics are varied and focus on essential areas of biomedical and biochemical sciences:

  • Monoclonal and Polyclonal Antibodies Research
  • Viral Infectious Diseases and Gene Expression in Insects
  • Glycosylation and Glycoproteins Research
  • Microfluidic and Bio-sensing Technologies
  • Protein purification and stability
  • SARS-CoV-2 and COVID-19 Research
  • Transgenic Plants and Applications

Their recent publications demonstrate ongoing contributions to both applied and clinical research. Notable papers include:

  • "Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial," 2022, published in The Lancet
  • "Mammalian cell culture for production of recombinant proteins: A review of the critical steps in their biomanufacturing," 2020, published in Biotechnology Advances
  • "Applications of bio-capacitance to cell culture manufacturing," 2022, published in Biotechnology Advances
  • "High-throughput and high-sensitivity N-Glycan profiling: A platform for biopharmaceutical development and disease biomarker discovery," 2021, published in Analytical Biochemistry
  • "The role of protein hydrolysates in prolonging viability and enhancing antibody production of CHO cells," 2021, published in Applied Microbiology and Biotechnology

The frequent co-authors collaborating with this researcher include:

  • Yongjing Xie
  • Elham Salimi
  • D. J. Thomson
  • Greg E. Bridges
  • Adam Bergin

The researcher publishes regularly in a select group of journals. The most frequent venues for their work are:

  • Glycobiology
  • Biotechnology Progress
  • Journal of Biotechnology
  • Biotechnology Advances
  • Analytical Biochemistry

Best Publications

  • Animal cell cultures: recent achievements and perspectives in the production of biopharmaceuticals

    Michael Butler

  • Expression systems for therapeutic glycoprotein production.

    Yves Durocher;Michael Butler

  • Mammalian cell biotechnology. A practical approach.

    M. Butler

  • Growth inhibition in animal cell culture. The effect of lactate and ammonia.

    T. Hassell;S. Gleave;M. Butler

  • Effects of ammonia on CHO cell growth, erythropoietin production, and glycosylation.

    M. Yang;M. Butler

  • Review of dengue virus and the development of a vaccine.

    Sarah Murrell;Suh-Chin Wu;Suh-Chin Wu;Michael Butler

  • Optimisation of the Cellular Metabolism of Glycosylation for Recombinant Proteins Produced by Mammalian Cell Systems

    M. Butler

  • Animal Cell Culture and Technology

    Michael Butler

  • Enhanced Production of Monomeric Interferon‐β by CHO Cells through the Control of Culture Conditions

    J. Rodriguez;M. Spearman;N. Huzel;M. Butler

  • Recent advances in technology supporting biopharmaceutical production from mammalian cells.

    M. Butler;A. Meneses-Acosta

  • Detailed glycan analysis of serum glycoproteins of patients with congenital disorders of glycosylation indicates the specific defective glycan processing step and provides an insight into pathogenesis

    Michael Butler;D. Quelhas;Alison J. Critchley;Hubert Carchon

  • Dissolved oxygen concentration in serum-free continuous culture affects N-linked glycosylation of a monoclonal antibody.

    Jeremy P Kunkel;David C.H Jan;James C Jamieson;Michael Butler

  • The choice of mammalian cell host and possibilities for glycosylation engineering.

    Michael Butler;Maureen Spearman

  • Effects of ammonia and glucosamine on the heterogeneity of erythropoietin glycoforms.

    M. Yang;M. Butler

  • Strategies for the enhancement of recombinant protein production from mammalian cells by growth arrest

    Kevin Sunley;Michael Butler

  • Mammalian cell culture for production of recombinant proteins: A review of the critical steps in their biomanufacturing

    Róisín O’Flaherty;Adam Bergin;Evangelia Flampouri;Letícia Martins Mota

  • Glucose and glutamine metabolism of a murine B-lymphocyte hybridoma grown in batch culture.

    Fitzpatrick L;Jenkins Ha;Butler M

  • The effect of dissolved oxygen on the production and the glycosylation profile of recombinant human erythropoietin produced from CHO cells

    Veronica Restelli;Ming-Dong Wang;Norman Huzel;Martin Ethier

  • The availability of glucose to CHO cells affects the intracellular lipid-linked oligosaccharide distribution, site occupancy and the N-glycosylation profile of a monoclonal antibody

    Bo Liu;Maureen Spearman;John Doering;Erica Lattová

  • Effect of ammonia on the glycosylation of human recombinant erythropoietin in culture.

    M. Yang;M. Butler

Frequent Co-Authors

Yves Durocher
Yves Durocher National Academies of Sciences, Engineering, and Medicine
Kenneth G. Standing
Kenneth G. Standing University of Manitoba
Mohamed Al-Rubeai
Mohamed Al-Rubeai University College Dublin
Raymond A. Dwek
Raymond A. Dwek University of Oxford
John F. Kelly
John F. Kelly National Academies of Sciences, Engineering, and Medicine
Jaak Jaeken
Jaak Jaeken KU Leuven
Pauline M. Rudd
Pauline M. Rudd University College Cork
Werner Ens
Werner Ens University of Manitoba
Michael B. Sinclair
Michael B. Sinclair Sandia National Laboratories

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