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Chemistry
Ireland
2026

D-Index & Metrics

Chemistry

D-Index
75
Citations
23947
World Ranking
4386
National Ranking
11

Research.com Recognitions

  • 2026 - Research.com Chemistry in Ireland Leader Award
  • 2025 - Research.com Chemistry in Ireland Leader Award
  • 2023 - Research.com Chemistry in Ireland Leader Award
  • 2022 - Research.com Chemistry in Ireland Leader Award

Overview

Martin Caffrey is affiliated with Trinity College Dublin in Ireland and conducts research in the field of Biochemistry, Genetics and Molecular Biology. Their work spans multiple subfields including Molecular Biology, Materials Chemistry, Genetics, Infectious Diseases, and Oncology.

The scientist's research topics cover a range of areas such as Protein Structure and Dynamics, Lipid Membrane Structure and Behavior, Enzyme Structure and Function, RNA and protein synthesis mechanisms, Chemical Synthesis and Analysis, Receptor Mechanisms and Signaling, and Glycosylation and Glycoproteins Research.

Some of Martin Caffrey's recent publications include:

  • Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin (2020), published in Nature Communications
  • X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance (2020), published in Biochemistry
  • Structure and Functional Characterization of Membrane Integral Proteins in the Lipid Cubic Phase (2020), published in Journal of Molecular Biology
  • Bacterial Lipoprotein Posttranslational Modifications. New Insights and Opportunities for Antibiotic and Vaccine Development (2021), published in Frontiers in Microbiology
  • The SARS-CoV-2 envelope (E) protein forms a calcium- and voltage-activated calcium channel (2022), published in bioRxiv (Cold Spring Harbor Laboratory)

Frequent co-authors collaborating with Martin Caffrey are:

  • Chia-Ying Huang
  • Coilín Boland
  • Dietmar Weichert
  • Samir Olatunji
  • Eoin M. Scanlan

Martin Caffrey has published repeatedly in several scientific venues, including:

  • Crystal Growth & Design
  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Chemical Communications
  • Journal of Applied Crystallography

Best Publications

  • Crystal structure of the β2 adrenergic receptor-Gs protein complex.

    Søren G. F. Rasmussen;Brian T. DeVree;Yaozhong Zou;Andrew C. Kruse

  • Phases and phase transitions of the phosphatidylcholines

    Rumiana Koynova;Martin Caffrey

  • Structure and function of an irreversible agonist-β2 adrenoceptor complex

    Daniel M. Rosenbaum;Cheng Zhang;Joseph A. Lyons;Joseph A. Lyons;Ralph Holl

  • Crystallizing membrane proteins using lipidic mesophases

    Martin Caffrey;Vadim Cherezov

  • Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

    Yanyong Kang;X. Edward Zhou;Xiang Gao;Yuanzheng He

  • The phase diagram of the monoolein/water system: metastability and equilibrium aspects.

    Hong Qiu;Martin Caffrey

  • Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography

    Uwe Weierstall;Daniel James;Chong Wang;Thomas A. White

  • Serial femtosecond crystallography of G protein-coupled receptors.

    Wei Liu;Daniel Wacker;Cornelius Gati;Gye Won Han

  • Membrane protein crystallization.

    Martin Caffrey

  • The Temperature-Composition Phase Diagram and Mesophase Structure Characterization of the Monoolein/Water System

    Jason Briggs;Hesson Chung;Martin Caffrey

  • Room to Move: Crystallizing Membrane Proteins in Swollen Lipidic Mesophases

    Vadim Cherezov;Jeffrey Clogston;Miroslav Z. Papiz;Martin Caffrey;Martin Caffrey

  • Fluorescence quenching in model membranes. 3. Relationship between calcium adenosinetriphosphatase enzyme activity and the affinity of the protein for phosphatidylcholines with different acyl chain characteristics.

    Martin Caffrey;Gerald W. Feigenson

  • MemProtMD: Automated Insertion of Membrane Protein Structures into Explicit Lipid Membranes.

    Phillip J. Stansfeld;Joseph E. Goose;Martin Caffrey;Elisabeth P. Carpenter

  • A comprehensive review of the lipid cubic phase or in meso method for crystallizing membrane and soluble proteins and complexes

    Martin Caffrey

  • Controlling release from the lipidic cubic phase. Amino acids, peptides, proteins and nucleic acids.

    J. Clogston;M. Caffrey;M. Caffrey

  • Lipid-sugar interactions : relevance to anhydrous biology.

    M Caffrey;V Fonseca;A C Leopold

  • Diffuse-double layer at a membrane-aqueous interface measured with x-ray standing waves.

    MJ Bedzyk;GM Bommarito;M Caffrey;TL Penner

  • Crystallizing Membrane Proteins for Structure Determination: Use of Lipidic Mesophases

    Martin Caffrey

  • Phases and phase transitions of the hydrated phosphatidylethanolamines.

    Rumiana Koynova;Martin Caffrey

  • A lipid’s eye view of membrane protein crystallization in mesophases

    Martin Caffrey

  • A simple mechanical mixer for small viscous lipid-containing samples

    Anchi Cheng;Bernard Hummel;Hong Qiu;Martin Caffrey

Frequent Co-Authors

Vadim Cherezov
Vadim Cherezov University of Southern California
Wei Liu
Wei Liu Chinese Academy of Sciences
Michael J. Bedzyk
Michael J. Bedzyk Northwestern University
William Stillwell
William Stillwell Indiana University – Purdue University Indianapolis
Brian K. Kobilka
Brian K. Kobilka Stanford University
Stephen R. Wassall
Stephen R. Wassall Indiana University – Purdue University Indianapolis
Kay Diederichs
Kay Diederichs University of Konstanz
John E. Kinsella
John E. Kinsella Cornell University
Petra Fromme
Petra Fromme Arizona State University
Henry N. Chapman
Henry N. Chapman Universität Hamburg

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