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Biology and Biochemistry

D-Index
75
Citations
18749
World Ranking
5360
National Ranking
2543

Overview

Michael Forgac is affiliated with Tufts University in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a particular emphasis on molecular biology. Additional areas of study include renewable energy, sustainability and the environment, physiology, energy engineering and power technology, as well as structural biology.

The scientist's main research topics encompass ATP synthase and ATPases, mitochondrial function and pathology, RNA modifications and cancer, metalloenzymes and iron-sulfur proteins, calcium signaling and nucleotide metabolism, renal and related cancers, and hybrid renewable energy systems.

Michael Forgac has contributed to several publications, with recent papers including:

  • Regulation and function of V-ATPases in physiology and disease, 2020, Biochimica et Biophysica Acta (BBA) - Biomembranes
  • AKT Ser/Thr kinase increases V-ATPase-dependent lysosomal acidification in response to amino acid starvation in mammalian cells, 2020, Journal of Biological Chemistry
  • A nanobody against the V-ATPase c subunit inhibits metastasis of 4T1-12B breast tumor cells to lung in mice, 2024, Oncotarget
  • Isoform a4 of the vacuolar ATPase a subunit promotes 4T1-12B breast cancer cell-dependent tumor growth and metastasis in vivo, 2022, Journal of Biological Chemistry
  • Knockout of the a4 isoform of the V-ATPase subunit a reduces tumor growth and metastasis in vivo, 2022, The FASEB Journal

Frequent collaborators in Michael Forgac's research include Michael P. Collins, Kevin Su, Zhen Li, Mohammed A. Alshagawi, and Mariam K. Alamoudi.

The scientist's work is commonly published in venues such as the Journal of Biological Chemistry, Biochimica et Biophysica Acta (BBA) - Biomembranes, Oncotarget, and The FASEB Journal.

Best Publications

  • Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology.

    Michael Forgac

  • The vacuolar (H+)-ATPases--nature's most versatile proton pumps.

    Tsuyoshi Nishi;Michael Forgac

  • Structure, function and regulation of the vacuolar (H+)-ATPase.

    Tom H. Stevens;Michael Forgac

  • Structure and function of vacuolar class of ATP-driven proton pumps

    Forgac M

  • Regulation and isoform function of the V-ATPases.

    Masashi Toei;Regina Saum;Michael Forgac

  • Structure and Properties of the Vacuolar (H+)-ATPases

    Michael Forgac

  • Topography and subunit stoichiometry of the coated vesicle proton pump.

    H Arai;G Terres;S Pink;M Forgac

  • Recent Insights into the Structure, Regulation, and Function of the V-ATPases

    Kristina Cotter;Laura Stransky;Christina McGuire;Michael Forgac

  • Clathrin-coated vesicles contain an ATP-dependent proton pump.

    Michael Forgac;Lewis Cantley;Bertram Wiedenmann;Larry Altstiel

  • Function, structure and regulation of the vacuolar (H+)-ATPases.

    Kevin C. Jefferies;Daniel J. Cipriano;Michael Forgac

  • The Function of V-ATPases in Cancer

    Laura Stransky;Kristina Cotter;Michael Forgac

  • V-ATPase functions in normal and disease processes

    Ayana Hinton;Sarah Bond;Michael Forgac

  • The amino-terminal domain of the vacuolar proton-translocating ATPase a subunit controls targeting and in vivo dissociation, and the carboxyl-terminal domain affects coupling of proton transport and ATP hydrolysis.

    Shoko Kawasaki-Nishi;Katherine Bowers;Tsuyoshi Nishi;Michael Forgac

  • Function of a subunit isoforms of the V-ATPase in pH homeostasis and in vitro invasion of MDA-MB231 human breast cancer cells.

    Ayana Hinton;Souad R. Sennoune;Sarah Bond;Min Fang

  • Proton conduction and bafilomycin binding by the V0 domain of the coated vesicle V-ATPase.

    Jimin Zhang;Yu Feng;M. Forgac

  • Inhibition of vacuolar H(+)-ATPase by disulfide bond formation between cysteine 254 and cysteine 532 in subunit A.

    Yu Feng;M. Forgac

  • Yeast V-ATPase Complexes Containing Different Isoforms of the 100-kDa a-subunit Differ in Coupling Efficiency and in VivoDissociation

    Shoko Kawasaki-Nishi;Tsuyoshi Nishi;Michael Forgac

  • Structure of the vacuolar ATPase by electron microscopy.

    Stephan Wilkens;Elena Vasilyeva;Michael Forgac

  • Characterization of the V0 domain of the coated vesicle (H+)-ATPase.

    J Zhang;M Myers;M Forgac

  • STRUCTURE, FUNCTION AND REGULATION OF THE VACUOLAR

    Tom H. Stevens;Michael Forgac

Frequent Co-Authors

Tom H. Stevens
Tom H. Stevens University of Oregon
Carol A. Kumamoto
Carol A. Kumamoto Tufts University
Martin E. Maier
Martin E. Maier University of Tübingen
Yoh Wada
Yoh Wada Osaka University
Patricia M. Kane
Patricia M. Kane SUNY Upstate Medical University
Rosemary O'Connor
Rosemary O'Connor University College Cork
Michael W. Hunkapiller
Michael W. Hunkapiller Pacific Biosciences (United States)
John H. Richards
John H. Richards California Institute of Technology
Ira M. Herman
Ira M. Herman Tufts University
Dennis Brown
Dennis Brown Harvard University

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