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Microbiology

D-Index
46
Citations
12093
World Ranking
4850
National Ranking
1872

Overview

Lucas R. Hoffman is affiliated with the University of Washington in the United States. Their research primarily focuses on the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a specialized interest in Pulmonary and Respiratory Medicine, Molecular Biology, Epidemiology, Molecular Medicine, and Infectious Diseases.

The main topics of their work include:

  • Cystic Fibrosis Research Advances
  • Bacterial biofilms and quorum sensing
  • Gut microbiota and health
  • Antibiotic Resistance in Bacteria
  • Pediatric health and respiratory diseases
  • Neonatal Respiratory Health Research
  • Child Nutrition and Feeding Issues

They have contributed extensively to academic journals, with frequent publications in the following venues:

  • Journal of Cystic Fibrosis
  • Annals of the American Thoracic Society
  • mBio
  • American Journal of Respiratory and Critical Care Medicine
  • PLoS ONE

Among their recent significant publications are:

  • "Lung function and microbiota diversity in cystic fibrosis," 2020, Microbiome
  • "Pharmacologic improvement of CFTR function rapidly decreases sputum pathogen density, but lung infections generally persist," 2023, Journal of Clinical Investigation
  • "Elexacaftor/tezacaftor/ivacaftor and gastrointestinal outcomes in cystic fibrosis: Report of promise-GI," 2022, Journal of Cystic Fibrosis
  • "Fecal dysbiosis in infants with cystic fibrosis is associated with early linear growth failure," 2020, Nature Medicine
  • "Elevated exopolysaccharide levels in Pseudomonas aeruginosa flagellar mutants have implications for biofilm growth and chronic infections," 2020, PLoS Genetics

Their work often involves collaboration with several recurring co-authors, including:

  • Christopher E. Pope
  • Daniel J. Wolter
  • Hillary S. Hayden
  • Margaret Rosenfeld
  • Stephen J. Salipante

Best Publications

  • Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients.

    Eric E. Smith;Danielle G. Buckley;Zaining Wu;Channakhone Saenphimmachak

  • Aminoglycoside antibiotics induce bacterial biofilm formation

    Lucas R. Hoffman;David A. D'Argenio;Michael J. MacCoss;Zhaoying Zhang

  • Virus-cell and cell-cell fusion.

    L. D. Hernandez;L. R. Hoffman;T. G. Wolfsberg;J. M. White

  • Failure to Recover to Baseline Pulmonary Function after Cystic Fibrosis Pulmonary Exacerbation

    Don B. Sanders;Rachel C. L. Bittner;Margaret Rosenfeld;Lucas R. Hoffman

  • Selection for Staphylococcus aureus small-colony variants due to growth in the presence of Pseudomonas aeruginosa

    Lucas R. Hoffman;Éric Déziel;David A D'Argenio;François Lépine

  • Growth phenotypes of Pseudomonas aeruginosa lasR mutants adapted to the airways of cystic fibrosis patients.

    David A. D'Argenio;Manhong Wu;Lucas R. Hoffman;Hemantha D. Kulasekara

  • Restoring Cystic Fibrosis Transmembrane Conductance Regulator Function Reduces Airway Bacteria and Inflammation in People with Cystic Fibrosis and Chronic Lung Infections

    Katherine B. Hisert;Sonya L. Heltshe;Christopher Pope;Peter Jorth

  • Pseudomonas aeruginosa lasR mutants are associated with cystic fibrosis lung disease progression.

    Lucas R. Hoffman;Hemantha D. Kulasekara;Julia Emerson;Laura S. Houston

  • Asymmetrical Distribution of the Second Messenger c-di-GMP upon Bacterial Cell Division

    Matthias Christen;Hemantha D. Kulasekara;Beat Christen;Bridget R. Kulasekara

  • LasR Variant Cystic Fibrosis Isolates Reveal an Adaptable Quorum-Sensing Hierarchy in Pseudomonas aeruginosa

    John B Feltner;Daniel J. Wolter;Daniel J. Wolter;Christopher E. Pope;Marie-Christine Groleau

  • Lung function and microbiota diversity in cystic fibrosis

    Leah Cuthbertson;Alan W. Walker;Alan W. Walker;Anna E. Oliver;Geraint B. Rogers

  • The microbiota in bronchoalveolar lavage from young children with chronic lung disease includes taxa present in both the oropharynx and nasopharynx

    Robyn Marsh;Mirjam Kaestli;Anne Chang;Anne Chang;Michael Binks

  • Pharmacologic improvement of CFTR function rapidly decreases sputum pathogen density, but lung infections generally persist

    Unknown

  • Staphylococcus aureus Small-Colony Variants Are Independently Associated With Worse Lung Disease in Children With Cystic Fibrosis

    Daniel J. Wolter;Julia C. Emerson;Sharon McNamara;Anne M. Buccat

  • Does bacterial density in cystic fibrosis sputum increase prior to pulmonary exacerbation

    Franziska A. Stressmann;Geraint B. Rogers;Peter Marsh;Andrew K. Lilley

  • Long-term cultivation-independent microbial diversity analysis demonstrates that bacterial communities infecting the adult cystic fibrosis lung show stability and resilience.

    Franziska Anne Stressmann;Geraint B Rogers;Christopher J van der Gast;Peter Marsh

  • Heterogeneity in surface sensing suggests a division of labor in Pseudomonas aeruginosa populations.

    Catherine R Armbruster;Calvin K Lee;Jessica Parker-Gilham;Jaime de Anda

  • Return of FEV1 after pulmonary exacerbation in children with cystic fibrosis

    Don B. Sanders;Don B. Sanders;Lucas R. Hoffman;Julia Emerson;Ronald L. Gibson

  • Human gut bacteria contain acquired interbacterial defence systems

    Benjamin D. Ross;Adrian J. Verster;Matthew C. Radey;Danica T. Schmidtke

  • Human and Extracellular DNA Depletion for Metagenomic Analysis of Complex Clinical Infection Samples Yields Optimized Viable Microbiome Profiles

    Maria T. Nelson;Christopher E. Pope;Robyn L. Marsh;Daniel J. Wolter

  • Nutrient availability as a mechanism for selection of antibiotic tolerant Pseudomonas aeruginosa within the CF airway.

    Lucas R. Hoffman;Anthony R. Richardson;Laura S. Houston;Hemantha D. Kulasekara

  • Pseudomonas aeruginosa in vitro phenotypes distinguish cystic fibrosis infection stages and outcomes

    Nicole Mayer-Hamblett;Margaret Rosenfeld;Ronald L. Gibson;Bonnie W. Ramsey

  • Structure-based identification of an inducer of the low-pH conformational change in the influenza virus hemagglutinin: irreversible inhibition of infectivity.

    Lucas R. Hoffman;I. D. Kuntz;Judith M. White

  • Clinical Effectiveness of Elexacaftor/Tezacftor/Ivacaftor in People with Cystic Fibrosis.

    David P Nichols;David P Nichols;Alex C Paynter;Sonya L. Heltshe;Sonya L. Heltshe;Scott H Donaldson

Frequent Co-Authors

Geraint B. Rogers
Geraint B. Rogers Flinders University
Jane L. Burns
Jane L. Burns University of Washington
Samuel I. Miller
Samuel I. Miller University of Washington
Kenneth D. Bruce
Kenneth D. Bruce King's College London
Elhanan Borenstein
Elhanan Borenstein Tel Aviv University
Margaret Rosenfeld
Margaret Rosenfeld University of Washington
Bonnie W. Ramsey
Bonnie W. Ramsey University of Washington
Anne B. Chang
Anne B. Chang Boston Children's Hospital
Matthew R. Parsek
Matthew R. Parsek University of Washington
Alan W. Walker
Alan W. Walker University of Aberdeen

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