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Biology and Biochemistry

D-Index
50
Citations
9422
World Ranking
17601
National Ranking
7222

Overview

Lawrence F. Povirk is affiliated with the Virginia Commonwealth University Medical Center in the United States. Their research primarily focuses on the field of Biochemistry, Genetics and Molecular Biology, with significant contributions to Molecular Biology and intersecting areas such as Cancer Research, Molecular Medicine, Epidemiology, and Oncology.

Their work centers around several main topics, including DNA Repair Mechanisms, Carcinogens and Genotoxicity Assessment, Mitochondrial Function and Pathology, Cancer therapeutics and mechanisms, Antibiotic Resistance in Bacteria, Pneumocystis jirovecii pneumonia detection and treatment, and Cancer-related Molecular Pathways.

Recent publications by Lawrence F. Povirk include:

  • ATM phosphorylates PP2A subunit A resulting in nuclear export and spatiotemporal regulation of the DNA damage response, 2022, Cellular and Molecular Life Sciences
  • Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks, 2020, UNC Libraries
  • ATM phosphorylates PP2A subunit A resulting in nuclear export and spatiotemporal regulation of the DNA damage response, 2021, bioRxiv (Cold Spring Harbor Laboratory)
  • Nonhomologous end joining of complex DNA double-strand breaks with proximal thymine glycol and interplay with base excision repair, 2020, UNC Libraries
  • Trimming of damaged 3' overhangs of DNA double-strand breaks by the Metnase and Artemis endonucleases, 2021, UNC Libraries

Frequent co-authors collaborating with Povirk include:

  • Kristoffer Valerie
  • Dale A. Ramsden
  • Konstantin Akopiants
  • Amrita Sule
  • James Watson

Their work has been published mainly in venues such as UNC Libraries, Cellular and Molecular Life Sciences, and bioRxiv (Cold Spring Harbor Laboratory).

Best Publications

  • Regulation and mechanisms of mammalian double-strand break repair

    Kristoffer Valerie;Lawrence F Povirk

  • DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: bleomycin, neocarzinostatin and other enediynes

    Lawrence F. Povirk

  • Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion

    Sarah E. Golding;Elizabeth Rosenberg;Nicholas Valerie;Isa Hussaini

  • DNA damage and mutagenesis induced by nitrogen mustards.

    Lawrence F. Povirk;David E. Shuker

  • Genotoxicity of bleomycin.

    Lawrence F. Povirk;M.J. Finley Austin

  • Conversion of Phosphoglycolate to Phosphate Termini on 3′ Overhangs of DNA Double Strand Breaks by the Human Tyrosyl-DNA Phosphodiesterase hTdp1

    Kedar V. Inamdar;Jeffrey J. Pouliot;Tong Zhou;Susan P. Lees-Miller

  • Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells.

    Sarah E. Golding;Rhiannon N. Morgan;Bret R. Adams;Amy J. Hawkins

  • Extracellular signal-related kinase positively regulates ataxia telangiectasia mutated, homologous recombination repair, and the DNA damage response.

    Sarah E. Golding;Elizabeth Rosenberg;Steven Neill;Paul Dent

  • Structure of bleomycin-induced DNA double-strand breaks: predominance of blunt ends and single-base 5' extensions.

    Lawrence F. Povirk;Yi Hong Han;Robert J. Steighner

  • Bleomycin-induced DNA lesions at mutational hot spots: implications for the mechanism of double-strand cleavage.

    Robert J. Steighner;Lawrence F. Povirk

  • p53-Dependent accelerated senescence induced by ionizing radiation in breast tumour cells

    K R Jones;L W Elmore;C Jackson-Cook;G Demasters

  • Effect of apurinic/apyrimidinic endonucleases and polyamines on DNA treated with bleomycin and neocarzinostatin: specific formation and cleavage of closely opposed lesions in complementary strands.

    Povirk Lf;Houlgrave Cw

  • Accurate in vitro end joining of a DNA double strand break with partially cohesive 3'-overhangs and 3'-phosphoglycolate termini: effect of Ku on repair fidelity.

    Shuang Chen;Kedar V. Inamdar;Petra Pfeiffer;Elke Feldmann

  • Double strand break repair by homologous recombination is regulated by cell cycle-independent signaling via ATM in human glioma cells.

    Sarah E. Golding;Elizabeth Rosenberg;Ashraf Khalil;Alison McEwen;Alison McEwen

  • Effects of bryostatin 1 and other pharmacological activators of protein kinase C on 1-[β-d-arabinofuranosyl]cytosine-induced apoptosis in HL-60 human promyelocytic leukemia cells

    W. David Jarvis;Lawrence F. Povirk;Amy J. Turner;Rebecca S. Traylor

  • Binding of the nonprotein chromophore of neocarzinostatin to deoxyribonucleic acid.

    Lawrence F. Povirk;Irving H. Goldberg

  • Neocarzinostatin chromophore binds to deoxyribonucleic acid by intercalation

    Lawrence F. Povirk;Nanibhushan Dattagupta;Benjamin C. Warf;Irving H. Goldberg

  • Tyrosyl-DNA phosphodiesterase and the repair of 3'-phosphoglycolate-terminated DNA double-strand breaks.

    Tong Zhou;Konstantin Akopiants;Susovan Mohapatra;Peck Sun Lin

  • Double strand break repair by homologous recombination is regulated by cell cycle-independent signaling via ATM in human glioma cells. Vol. 279 (2004) 15402-15410

    Sarah E. Golding;Elizabeth Rosenberg;Ashraf Khalil;Alison McEwen

  • human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1)

    Tong Zhou;Jae Wan Lee;Haritha Tatavarthi;James R. Lupski

Frequent Co-Authors

Kristoffer Valerie
Kristoffer Valerie Virginia Commonwealth University
David A. Gewirtz
David A. Gewirtz Virginia Commonwealth University
James R. Lupski
James R. Lupski Baylor College of Medicine
Gregory A. Buck
Gregory A. Buck Virginia Commonwealth University
George R. Pettit
George R. Pettit Arizona State University
Steven J. Neill
Steven J. Neill University of the West of England
Paul Dent
Paul Dent Virginia Commonwealth University
Irving H. Goldberg
Irving H. Goldberg Harvard University

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