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Medicine

D-Index
87
Citations
22006
World Ranking
13807
National Ranking
158

Overview

Kimmo Kontula is affiliated with the University of Helsinki in Finland and conducts research primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans multiple subfields including Cardiology and Cardiovascular Medicine, Molecular Biology, Genetics, Endocrinology, Diabetes and Metabolism, and Ophthalmology.

Kontula's research topics focus on areas such as cardiac electrophysiology and arrhythmias, genetic associations and epidemiology, hormonal regulation and hypertension, retinal diseases and treatments, inflammatory bowel disease, ion channel regulation and function, and ECG monitoring and analysis.

Recent papers authored or co-authored by Kontula include:

  • Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility, 2022, Nature Genetics
  • Human essential hypertension: no significant association of polygenic risk scores with antihypertensive drug responses, 2020, Scientific Reports
  • Adverse Cardiovascular Outcomes and Antihypertensive Treatment: A Genome-Wide Interaction Meta-Analysis in the International Consortium for Antihypertensive Pharmacogenomics Studies, 2021, Clinical Pharmacology & Therapeutics
  • Pharmacoepigenetics of hypertension: genome-wide methylation analysis of responsiveness to four classes of antihypertensive drugs using a double-blind crossover study design, 2022, Epigenetics
  • Sequencing of over 100,000 individuals identifies multiple genes and rare variants associated with Crohns disease susceptibility, 2021, bioRxiv (Cold Spring Harbor Laboratory)

Frequent co-authors collaborating with Kontula include:

  • Timo P. Hiltunen
  • Stefan Mutter
  • Raija Lithovius
  • Per-Henrik Groop
  • Heini Sánez Tähtisalo

Kontula's publications have appeared in several scientific journals and preprint repositories, with multiple works published in PLoS ONE and bioRxiv, as well as contributions to Nature Genetics, Scientific Reports, and Clinical Pharmacology & Therapeutics.

Best Publications

  • Mutations of the Cardiac Ryanodine Receptor (RyR2) Gene in Familial Polymorphic Ventricular Tachycardia

    Päivi J. Laitinen;Kevin M. Brown;Kirsi Piippo;Heikki Swan

  • A primer-guided nucleotide incorporation assay in the genotyping of apolipoprotein E.

    Ann-Christine Syvänen;Katriina Aalto-Setälä;Leena Harju;Kimmo Kontula

  • Apolipoprotein E, dementia, and cortical deposition of beta-amyloid protein.

    Tuomo Polvikoski;Raimo Sulkava;Matti Haltia;Katariina Kainulainen

  • Arrhythmic disorder mapped to chromosome 1q42-q43 causes malignant polymorphic ventricular tachycardia in structurally normal hearts.

    Heikki Swan;Kirsi Piippo;Matti Viitasalo;Päivi Heikkilä

  • Sudden Death in Familial Polymorphic Ventricular Tachycardia Associated With Calcium Release Channel (Ryanodine Receptor) Leak

    Stephan E. Lehnart;Xander H.T. Wehrens;Päivi J. Laitinen;Steven R. Reiken

  • Family and twin studies in inflammatory bowel disease

    Leena Halme;Paulina Paavola-Sakki;Ulla Turunen;Maarit Lappalainen

  • CARD15/NOD2 gene variants are associated with familially occurring and complicated forms of Crohn’s disease

    T Heliö;L Halme;M Lappalainen;H Fodstad

  • Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture.

    Anna L. Lahti;Ville J. Kujala;Hugh Chapman;Ari-Pekka Koivisto

  • Increased Risk of Acute Myocardial Infarction in Carriers of the Hemochromatosis Gene Cys282Tyr Mutation A Prospective Cohort Study in Men in Eastern Finland

    Tomi-Pekka Tuomainen;Kimmo Kontula;Kristiina Nyyssönen;Timo A. Lakka

  • Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

    Dan E. Arking;Sara L. Pulit;Sara L. Pulit;Sara L. Pulit;Lia Crotti;Pim Van Der Harst

  • Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease

    Sun Gou Ji;Brian D. Juran;Sören Mucha;Trine Folseraas

  • Involvement of the cardiac ryanodine receptor/calcium release channel in catecholaminergic polymorphic ventricular tachycardia.

    Andrew R. Marks;Silvia Priori;Mirella Memmi;Kimmo Kontula

  • Angiotensinogen gene M235T polymorphism predicts left ventricular hypertrophy in endurance athletes

    Jouko Karjalainen;Urho M. Kujala;Anu Stolt;Matti Mäntysaari

  • Primary structure of human insulin-like growth factor-binding protein/placental protein 12 and tissue-specific expression of its mRNA

    M. Julkunen;R. Koistinen;K. Aalto-Setala;M. Seppala

  • Aging and genetic variation of plasma apolipoproteins. Relative loss of the apolipoprotein E4 phenotype in centenarians.

    J Louhija;H E Miettinen;K Kontula;M J Tikkanen

  • Evidence for Involvement of the Type 1 Angiotensin II Receptor Locus in Essential Hypertension

    Katariina Kainulainen;Markus Perola;Joseph Terwilliger;Jaakko Kaprio

  • Arg506Gln factor V mutation (factor V Leiden) in patients with ischaemic cerebrovascular disease and survivors of myocardial infarction.

    Kimmo Kontula;Antti Ylikorkala;Helena Miettinen;Alpo Vuorio

  • Prevalence of Alzheimer’s disease in very elderly people A prospective neuropathological study

    T Polvikoski;R Sulkava;L Myllykangas;IL Notkola

  • Binding of progestins to the glucocorticoid receptor. Correlation to their glucocorticoid-like effects on in vitro functions of human mononuclear leukocytes.

    Kimmo Kontula;Timo Paavonen;Tapani Luukkainen;Leif C. Andersson

  • The SLC6A14 gene shows evidence of association with obesity

    Elina Suviolahti;Laura J. Oksanen;Miina Öhman;Rita M. Cantor

Frequent Co-Authors

Martti Färkkilä
Martti Färkkilä University of Helsinki
Christopher Newton-Cheh
Christopher Newton-Cheh Harvard University
Markus Perola
Markus Perola Finnish Institute for Health and Welfare
Olli A. Jänne
Olli A. Jänne University of Helsinki
Veikko Salomaa
Veikko Salomaa Finnish Institute for Health and Welfare
Aarno Palotie
Aarno Palotie University of Helsinki
Raimo Sulkava
Raimo Sulkava University of Eastern Finland
Tatu A. Miettinen
Tatu A. Miettinen University of Helsinki
Jaakko Kaprio
Jaakko Kaprio University of Helsinki

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