Kevin Jon Williams

Overview

Best Publications

• The Response-to-Retention Hypothesis of Early Atherogenesis

  Kevin Jon Williams;Ira Tabas

  1805
  Citations

• Subendothelial Lipoprotein Retention as the Initiating Process in Atherosclerosis: Update and Therapeutic Implications

  Ira Tabas;Kevin Jon Williams;Jan Borén

  1747
  Citations

• THE RESPONSE-TO-RETENTION HYPOTHESIS OF ATHEROGENESIS REINFORCED

  Kevin Jon Williams;Ira Tabas

  606
  Citations

• Letter by Williams and Tabas regarding article "atherosclerosis 2005: recent discoveries and novel hypotheses".

  Kevin Jon Williams;Ira Tabas

  483
  Citations

• Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling

  Autumn G. York;Kevin J. Williams;Joseph P. Argus;Quan D. Zhou

  472
  Citations

• The central role of arterial retention of cholesterol-rich apolipoprotein-B-containing lipoproteins in the pathogenesis of atherosclerosis: a triumph of simplicity

  Jan Borén;Kevin Jon Williams

  466
  Citations

• Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins.

  S L Schissel;J Tweedie-Hardman;J H Rapp;G Graham

  459
  Citations

• An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans

  Adil Mardinoglu;Hao Wu;Elias Bjornson;Cheng Zhang

  400
  Citations

• Secretory Sphingomyelinase, a Product of the Acid Sphingomyelinase Gene, Can Hydrolyze Atherogenic Lipoproteins at Neutral pH IMPLICATIONS FOR ATHEROSCLEROTIC LESION DEVELOPMENT

  Scott L. Schissel;Xian-cheng Jiang;Judith Tweedie-Hardman;Tae-sook Jeong

  398
  Citations

• Recombinant HDL-like nanoparticles: a specific contrast agent for MRI of atherosclerotic plaques.

  Juan C Frias;Kevin Jon Williams;Edward A Fisher;Zahi A Fayad

  370
  Citations

• Mechanisms by which lipoprotein lipase alters cellular metabolism of lipoprotein(a), low density lipoprotein, and nascent lipoproteins. Roles for low density lipoprotein receptors and heparan sulfate proteoglycans.

  K J Williams;G M Fless;K A Petrie;M L Snyder

  367
  Citations

• Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production

  Meihui Pan;Arthur I. Cederbaum;Yuan-Li Zhang;Henry N. Ginsberg

  362
  Citations

• Zn2+-stimulated Sphingomyelinase Is Secreted by Many Cell Types and Is a Product of the Acid Sphingomyelinase Gene

  Scott L. Schissel;Edward H. Schuchman;Kevin Jon Williams;Ira Tabas

  359
  Citations

• Human vascular endothelial cells are a rich and regulatable source of secretory sphingomyelinase. Implications for early atherogenesis and ceramide-mediated cell signaling

  Sudhir Marathe;Scott L. Schissel;Michael J. Yellin;Nanda Beatini

  342
  Citations

• The Cellular Trafficking and Zinc Dependence of Secretory and Lysosomal Sphingomyelinase, Two Products of the Acid Sphingomyelinase Gene

  Scott L. Schissel;George A. Keesler;Edward H. Schuchman;Kevin Jon Williams

  292
  Citations

• The syndecan family of proteoglycans. Novel receptors mediating internalization of atherogenic lipoproteins in vitro.

  I V Fuki;K M Kuhn;I R Lomazov;V L Rothman

  287
  Citations

• FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption.

  Bethan L. Clifford;Leslie R. Sedgeman;Kevin J. Williams;Pauline Morand

  274
  Citations

• Lipoprotein lipase and sphingomyelinase synergistically enhance the association of atherogenic lipoproteins with smooth muscle cells and extracellular matrix. A possible mechanism for low density lipoprotein and lipoprotein(a) retention and macrophage foam cell formation.

  I. Tabas;Yueqing Li;R. W. Brocia;Shu Wen Xu

  267
  Citations

• Rapid regression of atherosclerosis: insights from the clinical and experimental literature.

  Kevin Jon Williams;Jonathan E Feig;Edward A Fisher

  266
  Citations

• Principles of dimer-specific gene regulation revealed by a comprehensive characterization of NF-κB family DNA binding

  Trevor Siggers;Abraham B Chang;Ana Teixeira;Daniel Wong

  257
  Citations