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Immunology

D-Index
62
Citations
15199
World Ranking
3123
National Ranking
1462

Overview

Keith B. Elkon is affiliated with the University of Washington in the United States. Their research primarily focuses on immunology, microbiology, and related biomedical fields, with a particular emphasis on systemic autoimmune diseases and immune responses.

Their recent publications include work on immune mechanisms and disease pathways:

  • Role of the cGAS-STING pathway in systemic and organ-specific diseases, 2022, Nature Reviews Nephrology
  • Acute skin exposure to ultraviolet light triggers neutrophil-mediated kidney inflammation, 2021, Proceedings of the National Academy of Sciences
  • The early local and systemic Type I interferon responses to ultraviolet B light exposure are cGAS dependent, 2020, Scientific Reports
  • Immune cell multiomics analysis reveals contribution of oxidative phosphorylation to B-cell functions and organ damage of lupus, 2022, Annals of the Rheumatic Diseases
  • B cell-activating factor (BAFF) from dendritic cells, monocytes and neutrophils is required for B cell maturation and autoantibody production in SLE-like autoimmune disease, 2023, Frontiers in Immunology

Among their frequent co-authors are Xizhang Sun, Sladjana Skopelja-Gardner, Lena Tanaka, Jie An, and Joyce Tai. These collaborations have contributed to advancing understanding in the fields of immunology and autoimmune disease mechanisms.

Their work has been published in venues including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Reviews Nephrology
  • Proceedings of the National Academy of Sciences
  • Scientific Reports
  • Annals of the Rheumatic Diseases

Keith B. Elkon's main fields of study include immunology and microbiology, medicine, and biochemistry, genetics, and molecular biology. They have contributed extensively to the subfields of immunology, rheumatology, molecular biology, dermatology, and cell biology.

Their research explores a variety of topics such as:

  • Systemic Lupus Erythematosus Research
  • Atherosclerosis and Cardiovascular Diseases
  • Interferon and Immune Responses
  • Immune Response and Inflammation
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Immune Cell Function and Interaction
  • Inflammasome and Immune Disorders

Best Publications

  • Systemic vasculitis with asthma and eosinophilia: a clinical approach to the Churg-Strauss syndrome

    John G. Lanham;Keith B. Elkon;Charles D. Pusey;Graham R. Hughes

  • Complement-dependent Clearance of Apoptotic Cells by Human Macrophages

    Dror Mevorach;John O. Mascarenhas;Debra Gershov;Keith B. Elkon

  • C-Reactive Protein Binds to Apoptotic Cells, Protects the Cells from Assembly of the Terminal Complement Components, and Sustains an Antiinflammatory Innate Immune Response

    Debra Gershov;SunJung Kim;Nathan Brot;Keith B. Elkon

  • SYSTEMIC EXPOSURE TO IRRADIATED APOPTOTIC CELLS INDUCES AUTOANTIBODY PRODUCTION

    Dror Mevorach;Jun Liang Zhou;Xin Song;Keith B. Elkon

  • Impaired Fas response and autoimmunity in Pten+/- mice

    Antonio Di Cristofano;Paraskevi Kotsi;Yu Feng Peng;Carlos Cordon-Cardo

  • Fas gene mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmunity.

    Jörn Drappa;Akshay K. Vaishnaw;Kathleen E. Sullivan;Jia Li Chu

  • Sensory neuronopathy and small cell lung cancer. Antineuronal antibody that also reacts with the tumor.

    Francesc Graus;Keith B. Elkon;Carlos Cordon-Cardo;Jerome B. Posner

  • The defect in Fas mRNA expression in MRL/lpr mice is associated with insertion of the retrotransposon, ETn.

    Jia Li Chu;Jorn Drappa;Andrew Parnassa;Keith B. Elkon

  • CD40 ligation induces apo-1/fas expression on human B lymphocytes and facilitates apoptosis through the apo-1/fas pathway

    Elaine J. Schattner;Keith B. Elkon;Dae Hyun Yoo;Joseph Tumang

  • The Fas protein is expressed at high levels on CD4+CD8+ thymocytes and activated mature lymphocytes in normal mice but not in the lupus-prone strain, MRL lpr/lpr.

    Jorn Drappa;Nathan Brot;Keith B. Elkon

  • The apoptosis-1/Fas protein in human systemic lupus erythematosus.

    Eduardo Mysler;Paolo Bini;Jörn Drappa;Paula Ramos

  • TNF-α-dependent maturation of local dendritic cells is critical for activating the adaptive immune response to virus infection

    Jose M. Trevejo;Michael W. Marino;Nicola Philpott;Regis Josien

  • The molecular basis for apoptotic defects in patients with CD95 (Fas/Apo-1) mutations

    Akshay K. Vaishnaw;Jason R. Orlinick;Jia Li Chu;Peter H. Krammer

  • Enhanced membrane binding of autoantibodies to cultured keratinocytes of systemic lupus erythematosus patients after ultraviolet B/ultraviolet A irradiation.

    Theo Dov Golan;Keith B. Elkon;Azzudin E. Gharavi;James G. Krueger

  • Ribosomal P autoantibodies in systemic lupus erythematosus. Frequencies in different ethnic groups and clinical and immunogenetic associations

    Frank C. Arnett;John D. Reveille;Haralampos M. Moutsopoulos;Liviu Georgescu

  • A program of cell death and extracellular matrix degradation is activated in the amnion before the onset of labor.

    Hanqin Lei;Emma E. Furth;Raghu Kalluri;Terry Chiou

  • A major role for the Fas pathway in acute graft-versus-host disease.

    Charles S. Via;Phuong Nguyen;Andrei Shustov;Joern Drappa

  • Tumor necrosis factor α plays a central role in immune-mediated clearance of adenoviral vectors

    Keith B. Elkon;Chau Ching Liu;Jason G. Gall;Jose Trevejo

  • Neonatal lupus risk to newborns of mothers with systemic lupus erythematosus

    Michael D. Lockshin;Eloisa Bonfa;Keith Elkon;Maurice L. Druzin

  • Clinical and serologic associations of the antiribosomal P protein antibody.

    Eloisa Bonfa;Eloisa Bonfa;Keith B. Elkon

Frequent Co-Authors

Nathan Brot
Nathan Brot Cornell University
Graham R. V. Hughes
Graham R. V. Hughes London Bridge Hospital
Peter H. Krammer
Peter H. Krammer German Cancer Research Center
Michael D. Lockshin
Michael D. Lockshin Cornell University
Herbert Weissbach
Herbert Weissbach Florida Atlantic University
Moses V. Chao
Moses V. Chao New York University
Erik Falck-Pedersen
Erik Falck-Pedersen Cornell University
Robert D. Inman
Robert D. Inman University of Toronto
Mary K. Crow
Mary K. Crow Hospital for Special Surgery
Giovanni Migliaccio
Giovanni Migliaccio University of Washington

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