John Sinclair mostly deals with Human cytomegalovirus, Virology, Molecular biology, Immunology and Cellular differentiation. He performs multidisciplinary studies into Human cytomegalovirus and Latency in his work. His Virology research is multidisciplinary, incorporating perspectives in Transcriptional regulation, General transcription factor, TATA-Box Binding Protein and Monocyte.
His biological study spans a wide range of topics, including HIV Long Terminal Repeat, Binding protein, Heterologous, Transfection and Promoter. His work on Virus as part of general Immunology research is frequently linked to Peripheral blood mononuclear cell and Population, thereby connecting diverse disciplines of science. His research integrates issues of Regulation of gene expression and Immediate early protein in his study of Cellular differentiation.
His primary areas of study are Human cytomegalovirus, Virology, Immunology, Virus and Molecular biology. John Sinclair performs integrative study on Human cytomegalovirus and Latency in his works. His Virology research incorporates elements of Gene expression and Cellular differentiation.
Many of his research projects under Immunology are closely connected to Betaherpesvirinae and Population with Betaherpesvirinae and Population, tying the diverse disciplines of science together. His work deals with themes such as Transcription factor, Gene, Immediate early protein and Promoter, TATA box, which intersect with Molecular biology. His Virus latency study integrates concerns from other disciplines, such as Congenital cytomegalovirus infection and Regulation of gene expression.
John Sinclair focuses on Human cytomegalovirus, Virology, Immune system, Lytic cycle and Myeloid. His Human cytomegalovirus study necessitates a more in-depth grasp of Virus. His studies deal with areas such as Haematopoiesis, Stem cell and Single-cell analysis as well as Virology.
His research in Immune system intersects with topics in S100A8, Antibody and Chemotaxis. His Lytic cycle study combines topics in areas such as Cell, Gene expression and Cellular differentiation. In his study, which falls under the umbrella issue of Myeloid, Bone marrow, CD34 and Tropism is strongly linked to Cell type.
Human cytomegalovirus, Virology, Lytic cycle, Immune system and Virus are his primary areas of study. Human cytomegalovirus is a subfield of Immunology that he explores. The study incorporates disciplines such as RNA, Pathogen and Transcriptome, Gene expression in addition to Lytic cycle.
His work carried out in the field of Virus brings together such families of science as Secretion, Cancer research and microRNA. As part of the same scientific family, John Sinclair usually focuses on CD14, concentrating on Cell biology and intersecting with Cytokine, Dendritic cell, Monocyte and Interleukin 10. His Myeloid research includes elements of Regulation of gene expression, Viral life cycle, GATA2 and Antigen.
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Monocytes are a major site of persistence of human cytomegalovirus in peripheral blood mononuclear cells.
Jean Taylor-Wiedeman;J. G. P. Sissons;L. K. Borysiewicz;J. H. Sinclair.
Journal of General Virology (1991)
Latency and reactivation of human cytomegalovirus.
John Sinclair;Patrick Sissons.
Journal of General Virology (2006)
Latency, chromatin remodeling, and reactivation of human cytomegalovirus in the dendritic cells of healthy carriers.
M. B. Reeves;P. A. MacAry;P. J. Lehner;J. G. P. Sissons.
Proceedings of the National Academy of Sciences of the United States of America (2005)
Detection of endogenous human cytomegalovirus in CD34+ bone marrow progenitors.
Marc Mendelson;Simon Monard;Patrick Sissons;John Sinclair.
Journal of General Virology (1996)
Induction of endogenous human cytomegalovirus gene expression after differentiation of monocytes from healthy carriers.
J Taylor-Wiedeman;P Sissons;J Sinclair.
Journal of Virology (1994)
Control of cytomegalovirus lytic gene expression by histone acetylation.
Jane C. Murphy;Wolfgang Fischle;Eric Verdin;John H. Sinclair.
The EMBO Journal (2002)
The human cytomegalovirus 80-kilodalton but not the 72-kilodalton immediate-early protein transactivates heterologous promoters in a TATA box-dependent mechanism and interacts directly with TFIID.
C Hagemeier;S Walker;R Caswell;T Kouzarides.
Journal of Virology (1992)
Aspects of Human Cytomegalovirus Latency and Reactivation
M Reeves;J Sinclair.
Current Topics in Microbiology and Immunology (2008)
Functional interaction between the HCMV IE2 transactivator and the retinoblastoma protein.
C Hagemeier;R Caswell;G Hayhurst;J Sinclair.
The EMBO Journal (1994)
Human Daxx-mediated Repression of Human Cytomegalovirus Gene Expression Correlates with a Repressive Chromatin Structure around the Major Immediate Early Promoter
David L. Woodhall;Ian J. Groves;Matthew B. Reeves;Gavin W. Wilkinson.
Journal of Biological Chemistry (2006)
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