World's Best Scientists 2026 revealed!

D-Index & Metrics

Microbiology

D-Index
65
Citations
14075
World Ranking
2518
National Ranking
219

Overview

John Sinclair is affiliated with the University of Cambridge in the United Kingdom and has contributed extensively to the fields of Medicine and Immunology and Microbiology through a research career encompassing over 60 publications. Their work spans several subfields including Epidemiology, Immunology, Molecular Biology, Parasitology, and Neurology.

The focus of Sinclair's research lies primarily in cytomegalovirus and herpesvirus studies, with notable involvement in related topics such as herpesvirus infections and treatments, Toxoplasma gondii research, immune cell function and interaction, HIV research and treatment, and both the long-term effects and clinical studies of COVID-19.

Among Sinclair's recent published papers are:

  • Spontaneous, persistent, T cell-dependent IFN-γ release in patients who progress to Long Covid (2024, Science Advances)
  • Advances in cytomegalovirus (CMV) biology and its relationship to health, diseases, and aging (2020, GeroScience)
  • Single cell analysis reveals human cytomegalovirus drives latently infected cells towards an anergic-like monocyte state (2020, eLife)
  • Targeting the latent human cytomegalovirus reservoir for T-cell-mediated killing with virus-specific nanobodies (2021, Nature Communications)
  • Human Cytomegalovirus Interleukin 10 Homologs: Facing the Immune System (2020, Frontiers in Cellular and Infection Microbiology)

Frequent co-authors in Sinclair's work include Mark R. Wills, Emma Poole, Ian J. Groves, Sarah Jackson, and Marianne Perera, indicating ongoing collaborative efforts within their research community.

The primary venues where Sinclair's research has been published are:

  • Viruses
  • The Journal of Heart and Lung Transplantation
  • Journal of General Virology
  • Pathogens
  • Frontiers in Cellular and Infection Microbiology

Best Publications

  • Monocytes are a major site of persistence of human cytomegalovirus in peripheral blood mononuclear cells.

    Jean Taylor-Wiedeman;J. G. P. Sissons;L. K. Borysiewicz;J. H. Sinclair

  • Latency and reactivation of human cytomegalovirus.

    John Sinclair;Patrick Sissons

  • Latency, chromatin remodeling, and reactivation of human cytomegalovirus in the dendritic cells of healthy carriers.

    M. B. Reeves;P. A. MacAry;P. J. Lehner;J. G. P. Sissons

  • Detection of endogenous human cytomegalovirus in CD34+ bone marrow progenitors.

    Marc Mendelson;Simon Monard;Patrick Sissons;John Sinclair

  • Induction of endogenous human cytomegalovirus gene expression after differentiation of monocytes from healthy carriers.

    J Taylor-Wiedeman;P Sissons;J Sinclair

  • Complex I Binding by a Virally Encoded RNA Regulates Mitochondria-Induced Cell Death

    Matthew B. Reeves;Matthew B. Reeves;Andrew A. Davies;Andrew A. Davies;Brian Patrick McSharry;Brian Patrick McSharry;Gavin William Grahame Wilkinson;Gavin William Grahame Wilkinson

  • Human cytomegalovirus: Latency and reactivation in the myeloid lineage.

    John Sinclair

  • Control of cytomegalovirus lytic gene expression by histone acetylation.

    Jane C. Murphy;Wolfgang Fischle;Eric Verdin;John H. Sinclair

  • Human cytomegalovirus sequences expressed in latently infected individuals promote a latent infection in vitro

    Felicia D Goodrum;Matthew Reeves;John Sinclair;Kevin High

  • Human cytomegalovirus infection of the monocyte/macrophage lineage in bone marrow.

    E. J. Minton;C. Tysoe;J. H. Sinclair;J. G. P. Sissons

  • The human cytomegalovirus 80-kilodalton but not the 72-kilodalton immediate-early protein transactivates heterologous promoters in a TATA box-dependent mechanism and interacts directly with TFIID.

    C Hagemeier;S Walker;R Caswell;T Kouzarides

  • Aspects of Human Cytomegalovirus Latency and Reactivation

    M Reeves;J Sinclair

  • Functional interaction between the HCMV IE2 transactivator and the retinoblastoma protein.

    C Hagemeier;R Caswell;G Hayhurst;J Sinclair

  • The transcription factor YY1 binds to negative regulatory elements in the human cytomegalovirus major immediate early enhancer/promoter and mediates repression in non-permissive cells.

    Ru Liu;Joan Baillie;J. G. Sissons;John H. Sinclair

  • Human Daxx-mediated Repression of Human Cytomegalovirus Gene Expression Correlates with a Repressive Chromatin Structure around the Major Immediate Early Promoter

    David L. Woodhall;Ian J. Groves;Matthew B. Reeves;Gavin W. Wilkinson

  • Latent and persistent infections of monocytes and macrophages

    John Sinclair;Patrick Sissons

  • An in vitro model for the regulation of human cytomegalovirus latency and reactivation in dendritic cells by chromatin remodelling.

    M. B. Reeves;P. J. Lehner;J. G. P. Sissons;J. H. Sinclair

  • Human Cytomegalovirus Encodes an MHC Class I-Like Molecule (UL142) That Functions to Inhibit NK Cell Lysis

    Mark R. Wills;Omodele Ashiru;Matthew B. Reeves;Georgina Okecha

  • The human cytomegalovirus 86K immediate early (IE) 2 protein requires the basic region of the TATA-box binding protein (TBP) for binding, and interacts with TBP and transcription factor TFIIB via regions of IE2 required for transcriptional regulation

    Richard Caswell;Christian Hagemeier;Chuang-Jiun Chiou;Gary Hayward

  • Disruption of PML-associated nuclear bodies mediated by the human cytomegalovirus major immediate early gene product.

    Gavin W. G. Wilkinson;Collette Kelly;John H. Sinclair;Carole Rickards

Frequent Co-Authors

Mark R. Wills
Mark R. Wills University of Cambridge
Antonio Alcami
Antonio Alcami Spanish National Research Council
Paul J. Lehner
Paul J. Lehner University of Cambridge
Michal Schwartz
Michal Schwartz Weizmann Institute of Science
Tony Kouzarides
Tony Kouzarides University of Cambridge
Martine J. Smit
Martine J. Smit Vrije Universiteit Amsterdam
Roger A. Barker
Roger A. Barker University of Cambridge
Gordon Dougan
Gordon Dougan University of Cambridge
Barry Slobedman
Barry Slobedman University of Sydney

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring careers related to microbiology often leads students to consider diverse fields in healthcare and public health. For those interested in further education, there are several accredited online mph programs easy to get into that offer flexible options for advancing knowledge in epidemiology, biostatistics, and community health.

Career pathways such as becoming a child life specialist’s salary can be rewarding for individuals passionate about helping children cope with illness and medical treatments. This field blends healthcare with emotional support, offering meaningful professional opportunities related to microbiology’s impact on human health.

For individuals overcoming challenges in their academic past, there are numerous online colleges that accept felons, providing second chances to pursue degrees and enter healthcare and science industries, including microbiology-related careers.

Additionally, specialized roles like functional medicine np programs offer innovative nursing paths focusing on holistic and personalized patient care, often integrating microbiological insights into treatment plans. These emerging fields highlight the versatility of a microbiology background.

Best Scientists Citing John Sinclair

Trending Scientists

Recently Published Articles