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Microbiology

D-Index
59
Citations
12672
World Ranking
3265
National Ranking
290

Overview

John McLauchlan is affiliated with the University of Glasgow in the United Kingdom. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with a focus on subfields including Hepatology, Epidemiology, Immunology, Infectious Diseases, and Molecular Biology.

The scientist's work addresses a range of topics centered on viral infections and immune responses. Key research themes include:

  • Hepatitis C virus research
  • Hepatitis B Virus Studies
  • Interferon and immune responses
  • Liver Disease Diagnosis and Treatment
  • HIV/AIDS drug development and treatment
  • Inflammasome and immune disorders
  • Cytokine Signaling Pathways and Interactions

McLauchlan has a record of publications in various scientific journals. Frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of General Virology
  • Viruses
  • Hypertension
  • Journal of Hypertension

Recent papers authored or co-authored by McLauchlan focus mainly on viral hepatitis and immune response mechanisms. These publications include:

  • Real world SOF/VEL/VOX retreatment outcomes and viral resistance analysis for HCV patients with prior failure to DAA therapy, 2021, Journal of Viral Hepatitis
  • Direct Antiviral Activity of IFN-Stimulated Genes Is Responsible for Resistance to Paramyxoviruses in ISG15-Deficient Cells, 2020, The Journal of Immunology
  • Real-World Outcomes of Direct-Acting Antiviral Treatment and Retreatment in United Kingdom-Based Patients Infected With Hepatitis C Virus Genotypes/Subtypes Endemic in Africa, 2021, The Journal of Infectious Diseases
  • Negative regulation of ACE2 by interferons in vivo and its genetic control, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • Conserved Induction of Distinct Antiviral Signalling Kinetics by Primate Interferon Lambda 4 Proteins, 2021, Frontiers in Immunology

Collaboration is a significant aspect of McLauchlan's research. Frequent co-authors include:

  • Connor Bamford
  • Elihú Aranday-Cortés
  • William L. Irving
  • Eleanor Barnes
  • M. Azim Ansari

Best Publications

  • The consensus sequence YGTGTTYY located downstream from the AATAAA signal is required for efficient formation of mRNA 3′ termini

    John McLauchlan;Dairena Gaffney;J.Lindsay Whitton;J.Barklie Clements

  • Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets

    John McLauchlan;Marius K. Lemberg;Graham Hope;Bruno Martoglio

  • Impact of direct acting antiviral therapy in patients with chronic hepatitis C and decompensated cirrhosis.

    Graham R. Foster;William L. Irving;Michelle C.M. Cheung;Alex J. Walker

  • MAIT cells are activated during human viral infections

    B van Wilgenburg;I Scherwitzl;E C Hutchinson;T Leng

  • Outcomes after successful direct-acting antiviral therapy for patients with chronic hepatitis C and decompensated cirrhosis

    Michelle C.M. Cheung;Alex J. Walker;Benjamin E. Hudson;Suman Verma

  • Properties of the hepatitis C virus core protein: a structural protein that modulates cellular processes

    McLauchlan J

  • Disrupting the association of hepatitis C virus core protein with lipid droplets correlates with a loss in production of infectious virus.

    Steeve Boulant;Paul Targett-Adams;John McLauchlan

  • The lipid droplet binding domain of hepatitis C virus core protein is a major determinant for efficient virus assembly.

    Anna Shavinskaya;Steeve Boulant;Francois Penin;John McLauchlan

  • Sequence motifs required for lipid droplet association and protein stability are unique to the hepatitis C virus core protein.

    R. Graham Hope;John McLauchlan

  • Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study.

    Clark D Russell;Cameron J Fairfield;Thomas M Drake;Lance Turtle

  • Structural Determinants That Target the Hepatitis C Virus Core Protein to Lipid Droplets

    Steeve Boulant;Steeve Boulant;Roland Montserret;R. Graham Hope;Maxime Ratinier

  • Hepatitis C Virus Core Protein Induces Lipid Droplet Redistribution in a Microtubule‐ and Dynein‐Dependent Manner

    Steeve Boulant;Mark W. Douglas;Laura Moody;Agata Budkowska

  • Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles.

    Wagane J. A. Benga;Wagane J. A. Benga;Sophie E. Krieger;Sophie E. Krieger;Maria Dimitrova;Maria Dimitrova;Mirjam B. Zeisel;Mirjam B. Zeisel

  • Live Cell Analysis and Targeting of the Lipid Droplet-binding Adipocyte Differentiation-related Protein

    Paul Targett-Adams;Doreen Chambers;Sarah Gledhill;R. Graham Hope

  • Visualization of Double-Stranded RNA in Cells Supporting Hepatitis C Virus RNA Replication

    Paul Targett-Adams;Steeve Boulant;John McLauchlan

  • Full Genome Sequence and sfRNA Interferon Antagonist Activity of Zika Virus from Recife, Brazil.

    Claire L. Donald;Benjamin Brennan;Stephanie L. Cumberworth;Veronica V. Rezelj

  • The domains required to direct core proteins of hepatitis C virus and GB virus-B to lipid droplets share common features with plant oleosin proteins.

    R. Graham Hope;Denis J. Murphy;John McLauchlan

  • The Hepatitis C Virus NS4B Protein Can trans-Complement Viral RNA Replication and Modulates Production of Infectious Virus

    Daniel M. Jones;Arvind H. Patel;Paul Targett-Adams;John McLauchlan

  • Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK.

    Chloe I Bloom;Thomas M Drake;Annemarie B Docherty;Brian J Lipworth

  • Herpes simplex virus IE63 acts at the posttranscriptional level to stimulate viral mRNA 3' processing.

    J McLauchlan;A Phelan;C Loney;R M Sandri-Goldin

  • A modular system for the assay of transcription regulatory signals: the sequence TAATGARAT is required for herpes simplex virus immediate early gene activation

    D F Gaffney;J McLauchlan;J L Whitton;J B Clements

Frequent Co-Authors

William L. Irving
William L. Irving University of Nottingham
Graham R. Foster
Graham R. Foster Queen Mary University of London
Arvind H. Patel
Arvind H. Patel University of Glasgow
Eleanor Barnes
Eleanor Barnes University of Oxford
Steeve Boulant
Steeve Boulant University of Florida
Paul Klenerman
Paul Klenerman University of Oxford
Peter Simmonds
Peter Simmonds University of Oxford
Frazer J. Rixon
Frazer J. Rixon University of Glasgow
Rory Bowden
Rory Bowden Walter and Eliza Hall Institute of Medical Research
K. Christopher Garcia
K. Christopher Garcia Stanford University

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