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Jean-Claude Sirard

Jean-Claude Sirard

D-Index & Metrics

Microbiology

D-Index
48
Citations
9854
World Ranking
4656
National Ranking
278

Overview

Jean-Claude Sirard is affiliated with the Institut Pasteur in France and has conducted extensive research in the field of medicine, particularly focusing on epidemiology, pulmonary and respiratory medicine, and immunology. Their work also covers microbiology and molecular medicine areas, contributing to a deeper understanding of respiratory infections and immune responses.

The primary research topics addressed by Jean-Claude Sirard include:

  • Pneumonia and Respiratory Infections
  • Immune Response and Inflammation
  • Neonatal Respiratory Health Research
  • Respiratory Viral Infections Research
  • Influenza Virus Research Studies
  • Antibiotic Resistance in Bacteria
  • Bacterial Infections and Vaccines

Jean-Claude Sirard has frequently published in several scientific venues with notable contributions appearing in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Host & Microbe
  • Antimicrobial Agents and Chemotherapy
  • Pharmaceutics
  • Proceedings of the National Academy of Sciences

Their recent influential papers encompass the following:

  • Exploration of Bacterial Bottlenecks and Streptococcus pneumoniae Pathogenesis by CRISPRi-Seq, 2020, Cell Host & Microbe
  • Synthetic gene-regulatory networks in the opportunistic human pathogen Streptococcus pneumoniae, 2020, Proceedings of the National Academy of Sciences
  • Competence remodels the pneumococcal cell wall exposing key surface virulence factors that mediate increased host adherence, 2023, PLoS Biology
  • mTOR-driven glycolysis governs induction of innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin, 2021, Mucosal Immunology
  • Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection, 2021, PLoS Pathogens

Collaboration is an integral part of Jean-Claude Sirard's research, with frequent co-authors including:

  • Mara Baldry
  • Delphine Cayet
  • Jan-Willem Veening
  • Christophe Carnoy
  • Charlotte Costa

Best Publications

  • Bacterial flagellins: mediators of pathogenicity and host immune responses in mucosa

    Hugo Cruz Ramos;Martin Rumbo;Jean Claude Sirard

  • Dendritic cells rapidly recruited into epithelial tissues via CCR6/CCL20 are responsible for CD8+ T cell crosspriming in vivo.

    Marie Le Borgne;Marie Le Borgne;Nathalie Etchart;Nathalie Etchart;Anne Goubier;Anne Goubier;Sergio A. Lira

  • Sustained desensitization to bacterial Toll-like receptor ligands after resolution of respiratory influenza infection.

    Arnaud Didierlaurent;John Goulding;Seema Patel;Robert Snelgrove

  • Flagellin stimulation of intestinal epithelial cells triggers CCL20-mediated migration of dendritic cells

    Frédéric Sierro;Bertrand Dubois;Alix Coste;Dominique Kaiserlian

  • The Microbiota Mediates Pathogen Clearance from the Gut Lumen after Non-Typhoidal Salmonella Diarrhea

    Kathrin Endt;Baerbel Stecher;Samuel Chaffron;Emma Slack

  • Flagellin Promotes Myeloid Differentiation Factor 88-Dependent Development of Th2-Type Response

    Arnaud Didierlaurent;Isabel Ferrero;Luc A. Otten;Bertrand Dubois

  • A key role of dendritic cells in probiotic functionality.

    Benoit Foligne;Georgia Zoumpopoulou;Joelle Dewulf;Amena Ben Younes

  • Lactate and short chain fatty acids produced by microbial fermentation downregulate proinflammatory responses in intestinal epithelial cells and myeloid cells.

    Carolina Iraporda;Agustina Juliana Errea;David Emmanuel Romanin;Delphine Cayet

  • Exposure to Bacterial CpG DNA Protects from Airway Allergic Inflammation by Expanding Regulatory Lung Interstitial Macrophages.

    Catherine Sabatel;Coraline Radermecker;Laurence Fievez;Genevieve Paulissen

  • Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide.

    Arnaud Didierlaurent;Brian Brissoni;Dominique Velin;Natalia Aebi

  • Role of Toll-like receptors in costimulating cytotoxic T cell responses.

    Katrin Schwarz;Tazio Storni;Vania Manolova;Arnaud Didierlaurent

  • THE ATXA GENE PRODUCT ACTIVATES TRANSCRIPTION OF THE ANTHRAX TOXIN GENES AND IS ESSENTIAL FOR VIRULENCE

    Zhihao Dai;Jean‐Claude ‐C Sirard;Michèle Mock;Theresa M Koehler

  • Activation of Type 3 Innate Lymphoid Cells and Interleukin 22 Secretion in the Lungs During Streptococcus pneumoniae Infection

    Laurye Van Maele;Christophe Carnoy;Delphine Cayet;Stoyan Ivanov

  • The three Bacillus anthracis toxin genes are coordinately regulated by bicarbonate and temperature.

    J C Sirard;M Mock;A Fouet

  • Characterization of the Bacillus anthracis S-layer: cloning and sequencing of the structural gene.

    I Etienne-Toumelin;J C Sirard;E Duflot;M Mock

  • Live attenuated Salmonella: a paradigm of mucosal vaccines.

    Jean-Claude Sirard;Florence Niedergang;Jean-Pierre Kraehenbuhl

  • Role of toxin functional domains in anthrax pathogenesis.

    Fabien Brossier;Martine Weber-Levy;Michele Mock;Jean-Claude Sirard

  • Interleukin-22 Reduces Lung Inflammation during Influenza A Virus Infection and Protects against Secondary Bacterial Infection

    Stoyan Ivanov;Joelle Renneson;Josette Fontaine;Adeline Barthelemy

  • Mucosal Administration of Flagellin Protects Mice from Streptococcus pneumoniae Lung Infection

    Natalia Muñoz;Laurye Van Maele;Juan M. Marqués;Analía Rial

  • How the gut senses its content.

    Arnaud Didierlaurent;Jean-Claude Sirard;Jean-Pierre Kraehenbuhl;Marian R. Neutra

  • Entry and survival of Salmonella typhimurium in dendritic cells and presentation of recombinant antigens do not require macrophage-specific virulence factors.

    Florence Niedergang;Jean-Claude Sirard;Corinne Tallichet Blanc;Jean-Pierre Kraehenbuhl

Frequent Co-Authors

Michèle Mock
Michèle Mock Institut Pasteur
Jean-Pierre Kraehenbuhl
Jean-Pierre Kraehenbuhl University of Lausanne
François Trottein
François Trottein Institut Pasteur
Arnaud Didierlaurent
Arnaud Didierlaurent University of Geneva
Jean-Christophe Renauld
Jean-Christophe Renauld Université Catholique de Louvain
Agnès Fouet
Agnès Fouet Institut Cochin
Laure Dumoutier
Laure Dumoutier Université Catholique de Louvain
Gérard Eberl
Gérard Eberl Université Paris Cité
Bernhard Ryffel
Bernhard Ryffel University of Orléans

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