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Molecular Biology

D-Index
49
Citations
10497
World Ranking
2619
National Ranking
1281

Research.com Recognitions

  • 2010 - Fellow of Alfred P. Sloan Foundation

Overview

Hunter B. Fraser is affiliated with Stanford University in the United States. Their research primarily falls within the field of Biochemistry, Genetics, and Molecular Biology, with a strong focus on Molecular Biology and Genetics. Additional subfields include Plant Science, Ecology, Evolution, Behavior and Systematics, and Rehabilitation. The scientist's work encompasses a broad range of topics related to genomics and molecular mechanisms.

Key research areas covered by Fraser include:

  • Genomics and Chromatin Dynamics
  • CRISPR and Genetic Engineering
  • Single-cell and spatial transcriptomics
  • Evolution and Genetic Dynamics
  • RNA and protein synthesis mechanisms
  • RNA Research and Splicing
  • Genomics and Phylogenetic Studies

Fraser has published extensively, with notable recent papers including:

  • "Primate cell fusion disentangles gene regulatory divergence in neurodevelopment," 2021, published in Nature
  • "Human-chimpanzee fused cells reveal cis-regulatory divergence underlying skeletal evolution," 2021, published in Nature Genetics
  • "The cis-regulatory effects of modern human-specific variants," 2021, published in eLife
  • "Bacterial Retrons Enable Precise Gene Editing in Human Cells," 2022, published in The CRISPR Journal
  • "Molecular mechanisms of coronary disease revealed using quantitative trait loci for TCF21 binding, chromatin accessibility, and chromosomal looping," 2020, published in Genome Biology

The frequent coauthors collaborating with Fraser include:

  • Alexander L. Starr
  • David Gokhman
  • Shi-An A. Chen
  • Roy Moh Lik Ang
  • Katya L. Mack

The scientist has published in a variety of venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings of the National Academy of Sciences
  • Zenodo (CERN European Organization for Nuclear Research)
  • eLife
  • Genome Biology

Within their career, Fraser was awarded the title of Fellow of the Alfred P. Sloan Foundation in 2010.

Best Publications

  • Evolutionary Rate in the Protein Interaction Network

    Hunter B. Fraser;Aaron E. Hirsh;Lars M. Steinmetz;Curt Scharfe

  • Factors underlying variable DNA methylation in a human community cohort

    Lucia L. Lam;Eldon Emberly;Hunter B. Fraser;Sarah M. Neumann

  • Protein dispensability and rate of evolution

    Aaron E. Hirsh;Hunter B. Fraser

  • Noise minimization in eukaryotic gene expression.

    Hunter B Fraser;Aaron E Hirsh;Guri Giaever;Jochen Kumm

  • N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility.

    Scott B. Snapper;Scott B. Snapper;Fuminao Takeshima;Inés Antón;Inés Antón;Ching-Hui Liu;Ching-Hui Liu

  • Detecting putative orthologs.

    D. P. Wall;H. B. Fraser;A. E. Hirsh

  • Functional genomic analysis of the rates of protein evolution

    Dennis P. Wall;Aaron E. Hirsh;Hunter B. Fraser;Jochen Kumm

  • Population-specificity of human DNA methylation.

    Hunter B Fraser;Lucia L Lam;Lucia L Lam;Sarah M Neumann;Sarah M Neumann;Michael S Kobor;Michael S Kobor

  • Coevolution of gene expression among interacting proteins

    Hunter B. Fraser;Aaron E. Hirsh;Dennis P. Wall;Michael B. Eisen

  • Conservation and evolution of cis-regulatory systems in ascomycete fungi.

    Audrey P Gasch;Alan M Moses;Derek Y Chiang;Hunter B Fraser

  • Gene expression drives local adaptation in humans

    Hunter B. Fraser

  • Ab initio construction of a eukaryotic transcriptome by massively parallel mRNA sequencing

    Moran Yassour;Tommy Kaplan;Hunter B. Fraser;Joshua Z. Levin

  • Genetic conflict reflected in tissue-specific maps of genomic imprinting in human and mouse.

    Tomas Babak;Brian DeVeale;Emily K Tsang;Yiqi Zhou

  • Modularity and evolutionary constraint on proteins

    Hunter B Fraser

  • A simple dependence between protein evolution rate and the number of protein-protein interactions

    Hunter B Fraser;Dennis P Wall;Aaron E Hirsh

  • Aging and gene expression in the primate brain

    Hunter B Fraser;Philipp Khaitovich;Joshua B Plotkin;Svante Pääbo

  • Functional Genetic Variants Revealed by Massively Parallel Precise Genome Editing

    Eilon Sharon;Eilon Sharon;Shi-An A. Chen;Neil M. Khosla;Justin D. Smith

  • Evidence for widespread adaptive evolution of gene expression in budding yeast

    Hunter B. Fraser;Alan M. Moses;Eric E. Schadt

  • Accounting for biases in riboprofiling data indicates a major role for proline in stalling translation.

    Carlo G. Artieri;Hunter B. Fraser

  • Genetic variation in MHC proteins is associated with T cell receptor expression biases

    Eilon Sharon;Leah V Sibener;Alexis Battle;Hunter B Fraser

Frequent Co-Authors

Michael S. Kobor
Michael S. Kobor University of British Columbia
Dmitri A. Petrov
Dmitri A. Petrov Stanford University
Joshua B. Plotkin
Joshua B. Plotkin University of Pennsylvania
Eric E. Schadt
Eric E. Schadt Icahn School of Medicine at Mount Sinai
Jonathan Dushoff
Jonathan Dushoff McMaster University
Dennis P. Wall
Dennis P. Wall Stanford University
Nadav Ahituv
Nadav Ahituv University of California, San Francisco
Michael B. Eisen
Michael B. Eisen University of California, Berkeley
Manuel Irimia
Manuel Irimia Pompeu Fabra University
Jonathan K. Pritchard
Jonathan K. Pritchard Stanford University

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