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Frédéric Triebel

Frédéric Triebel

D-Index & Metrics

Immunology

D-Index
67
Citations
14276
World Ranking
2690
National Ranking
113

Overview

Frédéric Triebel is affiliated with the University of Paris-Saclay in France and has contributed extensively to the fields of medicine and immunology. Their research primarily focuses on oncology, immunology, and pulmonary and respiratory medicine, with significant work intersecting multiple subfields such as surgery and radiology.

The scientist's work covers core topics including cancer immunotherapy and biomarkers, immunotherapy and immune responses, colorectal and anal carcinomas, lung cancer treatments and mutations, ferroptosis and cancer prognosis, CAR-T cell therapy research, and immune cell function and interaction.

Frequent coauthors collaborating with Frédéric Triebel include Martin Förster, Julio A. Peguero, Matthew Krebs, Christian Mueller, and Margarita Majem. These collaborations have contributed to a wide range of publications in prominent journals.

They have published numerous articles in leading venues, with the most frequent being:

  • Journal of Clinical Oncology
  • Annals of Oncology
  • Regular and Young Investigator Award Abstracts
  • Cancer Research
  • Clinical Cancer Research

Key recent publications illustrating their research interests are:

  • "Eftilagimod alpha, a soluble lymphocyte activation gene-3 (LAG-3) protein plus pembrolizumab in patients with metastatic melanoma" (2020, Journal for ImmunoTherapy of Cancer)
  • "A LAG-3-Specific Agonist Antibody for the Treatment of T Cell-Induced Autoimmune Diseases" (2020, The Journal of Immunology)
  • "Molecular characterization of HLA class II binding to the LAG-3 T cell co-inhibitory receptor" (2020, European Journal of Immunology)
  • "A phase II study (TACTI-002) in first-line metastatic non-small cell lung carcinoma investigating eftilagimod alpha (soluble LAG-3 protein) and pembrolizumab: Updated results from a PD-L1 unselected population." (2022, Journal of Clinical Oncology)
  • "Initial results from a phase II study (TACTI-002) in metastatic non-small cell lung or head and neck carcinoma patients receiving eftilagimod alpha (soluble LAG-3 protein) and pembrolizumab." (2020, Journal of Clinical Oncology)

Frédéric Triebel's scholarly output spans 79 publications primarily in medicine and 18 in immunology and microbiology, aligning with their focus on immune response mechanisms in oncology contexts. The range of topics and frequent publication venues indicate an active involvement in advancing understanding and treatment options related to cancer immunotherapy and related immune pathways.

Best Publications

  • LAG-3, a novel lymphocyte activation gene closely related to CD4.

    F Triebel;S Jitsukawa;E Baixeras;S Roman-Roman

  • Orchestration and Prognostic Significance of Immune Checkpoints in the Microenvironment of Primary and Metastatic Renal Cell Cancer

    Nicolas Giraldo;Nicolas Giraldo;Nicolas Giraldo;Etienne Becht;Etienne Becht;Etienne Becht;Franck Pages;Georgios P Skliris

  • CD4/major histocompatibility complex class II interaction analyzed with CD4‐ and lymphocyte activation gene‐3 (LAG‐3)‐Ig fusion proteins

    Bertrand Huard;Philippe Prigent;Muriel Tournier;Denis Bruniquel

  • Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens.

    E Baixeras;B Huard;C Miossec;S Jitsukawa

  • Characterization of the major histocompatibility complex class II binding site on LAG-3 protein.

    Bertrand Huard;Renato Mastrangeli;Philippe Prigent;Denis Bruniquel

  • LAG-3 expression defines a subset of CD4(+)CD25(high)Foxp3(+) regulatory T cells that are expanded at tumor sites.

    Chiara Camisaschi;Chiara Casati;Francesca Rini;Michela Perego

  • Lymphocyte-activation gene 3/major histocompatibility complex class II interaction modulates the antigenic response of CD4+ T lymphocytes

    Bertrand Huard;Muriel Tournier;Thierry Hercend;Frédéric Triebel

  • First-line chemoimmunotherapy in metastatic breast carcinoma: combination of paclitaxel and IMP321 (LAG-3Ig) enhances immune responses and antitumor activity

    Chrystelle Brignone;Maya Gutierrez;Fawzia Mefti;Etienne Brain

  • A Phase I Pharmacokinetic and Biological Correlative Study of IMP321, a Novel MHC Class II Agonist, in Patients with Advanced Renal Cell Carcinoma

    Chrystelle Brignone;Bernard Escudier;Caroline Grygar;Manon Marcu

  • MHC Class II Engagement by Its Ligand LAG-3 (CD223) Contributes to Melanoma Resistance to Apoptosis

    Patrice Hemon;Francette Jean-Louis;Kiran Ramgolam;Chrystelle Brignone

  • CD3/TCR Complex-Associated Lymphocyte Activation Gene-3 Molecules Inhibit CD3/TCR Signaling

    Sigrid Hannier;Muriel Tournier;Georges Bismuth;Frédéric Triebel

  • The negative regulatory function of the lymphocyte-activation gene-3 co-receptor (CD223) on human T cells

    Laëtitia Maçon-Lemaître;Frédéric Triebel

  • Cellular expression and tissue distribution of the human LAG-3-encoded protein, an MHC class II ligand.

    B. Huard;P. Gaulard;F. Faure;T. Hercend

  • Maturation and activation of dendritic cells induced by lymphocyte activation gene-3 (CD223).

    Susanne Andreae;Fabienne Piras;Nicolas Burdin;Frédéric Triebel

  • A gamma-chain complex forms a functional receptor on cloned human lymphocytes with natural killer-like activity.

    P. Moingeon;S. Jitsukawa;F. Faure;F. Troalen

  • Identification of a human CD8+ regulatory T cell subset that mediates suppression through the chemokine CC chemokine ligand 4.

    Simone A. Joosten;Krista E. van Meijgaarden;Nigel D. L. Savage;Tjitske de Boer

  • LAG-3: a regulator of T-cell and DC responses and its use in therapeutic vaccination

    Frédéric Triebel

  • Direct evidence to support the immunosurveillance concept in a human regressive melanoma.

    A Mackensen;G Carcelain;S Viel;M C Raynal

  • MHC class II signal transduction in human dendritic cells induced by a natural ligand, the LAG-3 protein (CD223).

    Susanne Andreae;Sandrine Buisson;Frédéric Triebel

  • A unique V-J-C-rearranged gene encodes a gamma protein expressed on the majority of CD3+ T cell receptor-alpha/beta- circulating lymphocytes.

    Frederic Triebel;Florence Faure;Marita Graziani;Setsuko Jitsukawa

Frequent Co-Authors

Thierry Hercend
Thierry Hercend University of Nantes
Bernard Escudier
Bernard Escudier Institut Gustave Roussy
Sergio Roman-Roman
Sergio Roman-Roman Institute Curie
Anne Caignard
Anne Caignard Grenoble Alpes University
Luc Dirix
Luc Dirix GZA Ziekenhuizen Campus Sint-Augustinus
Chiara Castelli
Chiara Castelli University of Milan
Dominique Charron
Dominique Charron Grenoble Alpes University
Licia Rivoltini
Licia Rivoltini Fondazione IRCCS Istituto Nazionale dei Tumori
Jagadeesh Bayry
Jagadeesh Bayry Indian Institute of Technology Palakkad
Enriqueta Felip
Enriqueta Felip Vall d'Hebron Institut de Recerca

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