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Genetics

D-Index
67
Citations
46892
World Ranking
2471
National Ranking
1109

Overview

David J. Lockhart is affiliated with ReCode Therapeutics in the United States, specializing in research that intersects medicine, biochemistry, genetics, and molecular biology. Their work primarily focuses on pulmonary and respiratory medicine, with additional interests in molecular biology and genetics. The research portfolio includes contributions to biomedical and electrical engineering fields as well.

The scientist has authored publications covering a range of topics including cystic fibrosis research advances, neonatal respiratory health research, CRISPR and genetic engineering, genetic and kidney cyst diseases, RNA interference and gene delivery, energy harvesting in wireless networks, and advanced biosensing and bioanalysis techniques.

Key recent papers by David J. Lockhart include:

  • "In vivo editing of lung stem cells for durable gene correction in mice" (2024), published in Science
  • "Dual SORT LNPs for multi-organ base editing" (2025), published in Nature Biotechnology
  • "Inhaled DNAI1 mRNA therapy for treatment of primary ciliary dyskinesia" (2025), published in Proceedings of the National Academy of Sciences
  • "WS05.01 RCT2100 rescues CFTR function in human bronchial epithelial cells and improves mucociliary clearance in CF ferrets" (2024), published in Journal of Cystic Fibrosis
  • "Lipid nanoparticle-encapsulated Dnai1 mRNA rescues ciliary activity in primary ciliary dyskinesia mouse cell models" (2025), published in Journal of Cell Science

Their frequent coauthors include Brandon A. Wustman, Subhashree Mohapatra, J. Cefalu, S. Katikaneni, and M. Hennig.

David J. Lockhart has frequently published in these venues:

  • Journal of Cystic Fibrosis
  • Science
  • Nature Biotechnology
  • Proceedings of the National Academy of Sciences
  • Journal of Cell Science

The combination of fields and topics illustrates a research profile strongly rooted in translational and experimental approaches to respiratory and genetic diseases. The work touches on advanced gene therapy techniques including CRISPR, base editing with lipid nanoparticles, and RNA-based therapies aimed at addressing complex pulmonary conditions and genetic dysfunctions related to cystic fibrosis and primary ciliary dyskinesia.

Best Publications

  • Expression monitoring by hybridization to high density oligonucleotide arrays

    David J. Lockhart;Eugene L. Brown;Gordon G. Wong;Mark S. Chee

  • Functional Characterization of the S. cerevisiae Genome by Gene Deletion and Parallel Analysis

    Elizabeth A. Winzeler;Daniel D. Shoemaker;Anna Astromoff;Hong Liang

  • High density synthetic oligonucleotide arrays

    Robert J. Lipshutz;Stephen P.A. Fodor;Thomas R. Gingeras;David J. Lockhart

  • A Genome-Wide Transcriptional Analysis of the Mitotic Cell Cycle

    Raymond J. Cho;Michael J. Campbell;Elizabeth A. Winzeler;Lars Steinmetz

  • Genomics, gene expression and DNA arrays.

    David J. Lockhart;Elizabeth A. Winzeler

  • Accessing Genetic Information with High-Density DNA Arrays

    Mark Chee;Robert Yang;Earl Hubbell;Anthony Berno

  • Functional and Genomic Analyses Reveal an Essential Coordination between the Unfolded Protein Response and ER-Associated Degradation

    Kevin J Travers;Christopher K Patil;Lisa Wodicka;David J Lockhart

  • Genome-wide expression monitoring in Saccharomyces cerevisiae

    Lisa Wodicka;Helin Dong;Michael Mittmann;Ming-Hsiu Ho

  • Nucleic acid probe libraries

    David J. Lockhart;Dirk Vetter;Martin Diggelmann

  • Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors.

    Nathanael S. Gray;Lisa Wodicka;Andy-Mark W. H. Thunnissen;Thea C. Norman

  • Replication Dynamics of the Yeast Genome

    M. K. Raghuraman;Elizabeth A. Winzeler;David Collingwood;Sonia Hunt

  • Analysis of gene expression profiles in normal and neoplastic ovarian tissue samples identifies candidate molecular markers of epithelial ovarian cancer

    John B. Welsh;Patrick P. Zarrinkar;Lisa M. Sapinoso;Suzanne G. Kern

  • Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases

    Todd A. Carter;Lisa M. Wodicka;Neil P. Shah;Anne Marie Velasco

  • Mitotic misregulation and human aging.

    Danith H. Ly;David J. Lockhart;Richard A. Lerner;Peter G. Schultz;Peter G. Schultz

  • Elevated gene expression levels distinguish human from non-human primate brains

    Mario Cáceres;Joel Lachuer;Matthew A. Zapala;John C. Redmond

  • Transcriptional regulation and function during the human cell cycle.

    Raymond J. Cho;Mingxia Huang;Michael J. Campbell;Helin Dong

  • Regional and strain-specific gene expression mapping in the adult mouse brain

    Rickard Sandberg;Rie Yasuda;Daniel G. Pankratz;Todd A. Carter

  • Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice

    Iiris Hovatta;Richard S. Tennant;Robert Helton;Robert A. Marr

  • Nucleic acid analysis techniques

    David J. Lockhart;Mark Chee;Kevin Gunderson;Chaoqiang Lai

  • Treatment of Fabry’s Disease with the Pharmacologic Chaperone Migalastat

    Dominique P Germain;Derralynn A Hughes;Kathleen Nicholls;Daniel G Bichet

Frequent Co-Authors

Mark S. Chee
Mark S. Chee Illumina (United States)
Thomas R. Gingeras
Thomas R. Gingeras Cold Spring Harbor Laboratory
Ronald W. Davis
Ronald W. Davis Stanford University
Elizabeth A. Winzeler
Elizabeth A. Winzeler University of California, San Diego
Janet A. Warrington
Janet A. Warrington Cybele Microbiome
Gordon G. Wong
Gordon G. Wong Pfizer (Canada)
Peter G. Schultz
Peter G. Schultz Scripps Research Institute
Iiris Hovatta
Iiris Hovatta University of Helsinki
Daniel G. Bichet
Daniel G. Bichet University of Montreal
George M. Church
George M. Church Harvard University

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