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Gordon G. Wong

Gordon G. Wong

Overview

Gordon G. Wong is affiliated with Pfizer (Canada) and conducts research primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans several subfields including Hematology, Molecular Biology, Immunology, Oncology, and Cancer Research.

The primary focus of Wong's research is on Acute Myeloid Leukemia (AML), with significant contributions to understanding the disease at the single-cell and molecular levels. Topics covered in their publications include Acute Myeloid Leukemia Research, Single-cell and spatial transcriptomics, Immune cells in cancer, CAR-T cell therapy research, Immune Cell Function and Interaction, Chronic Myeloid Leukemia Treatments, and Hematopoietic Stem Cell Transplantation.

Wong's notable recent papers include:

  • "Single-cell Transcriptional Atlas of Human Hematopoiesis Reveals Genetic and Hierarchy-Based Determinants of Aberrant AML Differentiation" (2025) published in Blood Cancer Discovery
  • "Single-cell transcriptional mapping reveals genetic and non-genetic determinants of aberrant differentiation in AML" (2023) published in bioRxiv (Cold Spring Harbor Laboratory)
  • "2020 - PRECISE SINGLE-CELL TRANSCRIPTOMIC MAPPING OF NORMAL AND LEUKEMIC CELL STATES REVEALS UNCONVENTIONAL LINEAGE PRIMING IN ACUTE MYELOID LEUKEMIA" (2024) published in Experimental Hematology
  • "Functional Investigation of the Argonaute Proteins in Human Hematopoietic Stem and Progenitor Cells" (2020) published in Blood
  • "Precise Single-Cell Transcriptomic Mapping of Leukemia Cell States Reveals Unconventional Lineage Priming in Acute Myeloid Leukemia" (2023) published in Blood

Frequent coauthors collaborating with Wong include:

  • John E. Dick
  • Andy G.X. Zeng
  • Ilaria Iacobucci
  • Sayyam Shah
  • Qingsong Gao

Wong's scientific output is commonly published in journals such as Blood, Blood Cancer Discovery, bioRxiv (Cold Spring Harbor Laboratory), Experimental Hematology, and Cancer Research, with multiple papers appearing in the prominent journal Blood.

The research conducted covers detailed transcriptomic mapping approaches and functional studies aimed at deciphering the behavior and differentiation pathways of hematopoietic and leukemic cells. This includes work on the genetic and non-genetic determinants influencing cell states in AML, and investigations into molecular components such as Argonaute proteins in hematopoietic stem and progenitor cells.

Best Publications

  • Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides

    Austin G. Smith;John K. Heath;Deborah D. Donaldson;Gordon G. Wong

  • Human GM-CSF: molecular cloning of the complementary DNA and purification of the natural and recombinant proteins

    Gordon G. Wong;JoAnn S. Witek;Patricia A. Temple;Kathleen M. Wilkens

  • Human IL-3 (multi-CSF): Identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3

    Yu Chung Yang;Agnes B. Ciarletta;Patricia A. Temple;Margaret P. Chung

  • Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors.

    Kenji Ikebuchi;Gordon G. Wong;Steven C. Clark;James N. Ihle

  • Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells

    Shih-Feng Tsai;David I. K. Martin;David I. K. Martin;Leonard I. Zon;Leonard I. Zon;Alan D. D'Andrea;Alan D. D'Andrea

  • Expression cloning of the murine erythropoietin receptor.

    Alan D. D'Andrea;Alan D. D'Andrea;Harvey F. Lodish;Gordon G. Wong

  • Human granulocyte-macrophage colony-stimulating factor is a neutrophil activator.

    Richard H. Weisbart;David W. Golde;Steven C. Clark;Gordon G. Wong

  • Multiple actions of interleukin 6 within a cytokine network

    Gordon G. Wong;Steven C. Clark

  • Purified human granulocyte-macrophage colony-stimulating factor: direct action on neutrophils.

    Judith C. Gasson;Richard H. Weisbart;Susan E. Kaufman;Steven C. Clark

  • Stimulation of haematopoiesis in primates by continuous infusion of recombinant human GM-CSF

    Robert E. Donahue;Elizabeth A. Wang;David K. Stone;Robert Kamen

  • Human CSF-1: molecular cloning and expression of 4-kb cDNA encoding the human urinary protein.

    Gordon G. Wong;Patricia A. Temple;Anne C. Leary;JoAnn S. Witek-Giannotti

  • Human recombinant granulocyte-macrophage colony-stimulating factor: a multilineage hematopoietin.

    Colin A. Sieff;Stephen G. Emerson;Robert E. Donahue;David G. Nathan

  • Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells

    Jean-Francois Moreau;Debra D. Donaldson;Frances Bennett;JoAnn Witek-Giannotti

  • Molecular characterization and expression of the gene encoding human erythroid-potentiating activity.

    Judith C. Gasson;David W. Golde;Susan E. Kaufman;Carol A. Westbrook

  • The human homolog of the JE gene encodes a monocyte secretory protein.

    B J Rollins;P Stier;T Ernst;G G Wong

  • Human Erythropoietin Receptor: Cloning, Expression, and Biologic Characterization

    Simon S. Jones;Alan D. D'Andrea;Lora L. Haines;Gordon G. Wong

  • Analysis in serum-free culture of the targets of recombinant human hemopoietic growth factors: interleukin 3 and granulocyte/macrophage-colony-stimulating factor are specific for early developmental stages

    Yoshiaki Sonoda;Yu-Chung Yang;Gordon G. Wong;Steven C. Clark

  • Stimulation of murine hemopoietic colony formation by human IL-6.

    G G Wong;J S Witek-Giannotti;P A Temple;R Kriz

  • Method for identification and isolation of DNA encoding a desired protein

    Steven C. Clark;Randal J. Kaufman;Gordon G. Wong

  • Purification of fetal hematopoietic progenitors and demonstration of recombinant multipotential colony-stimulating activity.

    Stephen G. Emerson;Colin A. Sieff;Elizabeth A. Wang;Gordon G. Wong

Frequent Co-Authors

Steven C. Clark
Steven C. Clark Pfizer (Canada)
Bice Perussia
Bice Perussia Kimmel Cancer Center
Thomas R. Gingeras
Thomas R. Gingeras Cold Spring Harbor Laboratory
Mark S. Chee
Mark S. Chee Illumina (United States)
David J. Lockhart
David J. Lockhart ReCode Therapeutics
Colin A. Sieff
Colin A. Sieff Harvard University
Judith C. Gasson
Judith C. Gasson University of California, Los Angeles
Makio Ogawa
Makio Ogawa Medical University of South Carolina
Joel F. Habener
Joel F. Habener Harvard University
Prabhat K. Sehgal
Prabhat K. Sehgal Harvard University

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