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Roland C. Grafström

Roland C. Grafström

D-Index & Metrics

Biology and Biochemistry

D-Index
51
Citations
7039
World Ranking
17359
National Ranking
276

Overview

Roland C. Grafström is affiliated with the Karolinska Institute in Sweden, focusing on research within Biochemistry, Genetics and Molecular Biology with a significant emphasis on Molecular Biology. Their work spans several subfields including Materials Chemistry, Health, Toxicology and Mutagenesis, as well as Information Systems and Management.

Their research encompasses a variety of topics related to nanotechnology and toxicology. Key areas of study include:

  • Nanoparticles: synthesis and applications
  • Research Data Management Practices
  • Scientific Computing and Data Management
  • Metabolomics and Mass Spectrometry Studies
  • Gene expression and cancer classification
  • Environmental Toxicology and Ecotoxicology
  • Nanotechnology research and applications

Grafström has published extensively in scientific journals, contributing to both experimental and computational research. Frequent publication venues include:

  • Nanomaterials
  • Zenodo (CERN European Organization for Nuclear Research)
  • Nature Nanotechnology
  • F1000Research
  • SSRN Electronic Journal

Their recent papers illustrate a focus on toxicology, nanoinformatics, and data management approaches. Notable publications include:

  • New approach methodologies in human regulatory toxicology - Not if, but how and when! (2023, Environment International)
  • NanoSolveIT Project: Driving nanoinformatics research to develop innovative and integrated tools for in silico nanosafety assessment (2020, Computational and Structural Biotechnology Journal)
  • Towards FAIR nanosafety data (2021, Nature Nanotechnology)
  • Transcriptomics in Toxicogenomics, Part I: Experimental Design, Technologies, Publicly Available Data, and Regulatory Aspects (2020, Nanomaterials)
  • Transcriptomics in Toxicogenomics, Part III: Data Modelling for Risk Assessment (2020, Nanomaterials)

Cooperation with other researchers is a significant aspect of their work. Frequent co-authors include:

  • Penny Nymark
  • Pekka Kohonen
  • Haralambos Sarimveis
  • Tomasz Puzyn
  • Nina Jeliazkova

Best Publications

  • Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain.

    Galina Selivanova;Violetta Iotsova;Violetta Iotsova;Ismail Okan;Michael Fritsche

  • High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth.

    Kristiina Iljin;Kirsi Ketola;Paula Vainio;Pasi Halonen

  • Cytotoxic and genotoxic effects of areca nut-related compounds in cultured human buccal epithelial cells.

    Kristina Sundqvist;Yun Liu;Jagadeesan Nair;Helmut Bartsch

  • The isolation of rat intestinal microsomes with stable cytochrome P-450 and their metabolism of benzo(alpha) pyrene.

    S.J. Stohs;R.C. Grafström;M.D. Burke;P.W. Moldéus

  • Cytotoxicity, thiol depletion and inhibition of O6-methylguanine-DNA methyltransferase by various aldehydes in cultured human bronchial fibroblasts.

    Hans Krokan;Roland C. Grafstrom;Kristina Sundqvist;Hermann Esterbauer

  • High throughput toxicity screening and intracellular detection of nanomaterials

    Andrew R. Collins;Balasubramanyam Annangi;Laura Rubio;Ricard Jordà Marcos

  • Cytochrome P450 expression and related metabolism in human buccal mucosa

    Martin Vondracek;Zheng Xi;Pia Larsson;Valerie Baker

  • Pathobiological Effects of Acrolein in Cultured Human Bronchial Epithelial Cells

    Roland C. Grafström;Jeannette M. Dypbukt;James C. Willey;Kristina Sundqvist

  • The eNanoMapper database for nanomaterial safety information

    Nina Jeliazkova;Charalampos Chomenidis;Philip Doganis;Bengt Fadeel

  • O6-alkylguanine-DNA alkyltransferase activity in normal human tissues and cells.

    Roland C. Grafstrom;Anthony E. Pegg;Benjamin F. Trump;Curtis C. Harris

  • Genotoxicity of formaldehyde in cultured human bronchial fibroblasts

    Roland C. Grafstrom;Rodger D. Curren;Li L. Yang;Curtis C. Harris

  • Repair of DNA Damage Caused by Formaldehyde in Human Cells

    Roland C. Grafstrom;Albert Fornace;Curtis C. Harris

  • Reduction of S-nitrosoglutathione by alcohol dehydrogenase 3 is facilitated by substrate alcohols via direct cofactor recycling and leads to GSH-controlled formation of glutathione transferase inhibitors

    Claudia A. Staab;Johan Ålander;Margareta Brandt;Johan Lengqvist

  • Mutagenesis of xeroderma pigmentosum fibroblasts by acrolein.

    Rodger D. Curren;Li L. Yang;Patricia M. Conklin;Roland C. Grafstrom

  • NanoSolveIT Project: Driving nanoinformatics research to develop innovative and integrated tools for in silico nanosafety assessment

    Antreas Afantitis;Georgia Melagraki;Panagiotis Isigonis;Andreas Tsoumanis

  • FORMATION OF DNA ADDUCTS IN HUMAN BUCCAL EPITHELIAL CELLS EXPOSED TO ACETALDEHYDE AND METHYLGLYOXAL IN VITRO

    Carlos E Vaca;Jan Anders Nilsson;Jia-Long Fang;Roland C Grafström

  • A transcriptomics data-driven gene space accurately predicts liver cytopathology and drug-induced liver injury.

    Pekka Kohonen;Juuso A. Parkkinen;Egon L. Willighagen;Egon L. Willighagen;Rebecca Ceder

  • Effects of Formaldehyde, Acetaldehyde, Benzoyl Peroxide, and Hydrogen Peroxide on Cultured Normal Human Bronchial Epithelial Cells

    Andrew J. Saladino;James C. Willey;John F. Lechner;Roland C. Grafstrom

  • Pathobiological effects of acetaldehyde in cultured human epithelial cells and fibroblasts

    Roland C. Grafström;Jeannette M. Dypbukt;Kristina Sundqvist;Luigi Atzori

  • Cysteinyl leukotrienes enhance growth of human airway epithelial cells

    G. D. Leikauf;H. E. Claesson;C. A. Doupnik;S. Hybbinette

Frequent Co-Authors

Curtis C. Harris
Curtis C. Harris National Institutes of Health
Egon Willighagen
Egon Willighagen Maastricht University
Haralambos Sarimveis
Haralambos Sarimveis National Technical University of Athens
Bengt Fadeel
Bengt Fadeel Karolinska Institute
Peter Moldéus
Peter Moldéus Karolinska Institute
Sten Orrenius
Sten Orrenius Karolinska Institute
Samuel Kaski
Samuel Kaski Aalto University
Ola Spjuth
Ola Spjuth Uppsala University
James C. Willey
James C. Willey University of Toledo
Olli Kallioniemi
Olli Kallioniemi Karolinska Institute

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