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Biology and Biochemistry

D-Index
58
Citations
13486
World Ranking
13080
National Ranking
5578

Overview

Thomas J. MacVittie is affiliated with the University of Maryland, Baltimore in the United States and has a research focus spanning several fields within medicine and molecular biology. Their academic contributions primarily address the effects of radiation exposure and related medical challenges.

Their recent published papers cover diverse aspects of radiation-related health issues, including both experimental models and clinical implications. Notable publications include:

  • Semi-Supervised Segmentation of Radiation-Induced Pulmonary Fibrosis From Lung CT Scans With Multi-Scale Guided Dense Attention (2021, IEEE Transactions on Medical Imaging)
  • Rat Models of Partial-body Irradiation with Bone Marrow-sparing (Leg-out PBI) Designed for FDA Approval of Countermeasures for Mitigation of Acute and Delayed Injuries by Radiation (2021, Health Physics)
  • Acute Radiation-induced Lung Injury in the Non-human Primate: A Review and Comparison of Mortality and Co-morbidities Using Models of Partial-body Irradiation with Marginal Bone Marrow Sparing and Whole Thorax Lung Irradiation (2020, Health Physics)
  • Age and Sex Divergence in Hematopoietic Radiosensitivity in Aged Mouse Models of the Hematopoietic Acute Radiation Syndrome (2022, Radiation Research)
  • Immune Reconstitution and Thymic Involution in the Acute and Delayed Hematopoietic Radiation Syndromes (2020, Health Physics)

The featured venues for their work highlight a concentration in radiation biology and health physics, including:

  • Health Physics
  • Radiation Research
  • International Journal of Radiation Biology
  • IEEE Transactions on Medical Imaging
  • Scientific Reports

MacVittie's research spans the main fields of medicine and biochemistry, genetics, and molecular biology. Within these broader categories, their work touches on several subfields:

  • Radiology, Nuclear Medicine and Imaging
  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Oncology
  • Cancer Research

The main topical areas explored in their research include:

  • Effects of Radiation Exposure
  • Radiation Therapy and Dosimetry
  • Mitochondrial Function and Pathology
  • Carcinogens and Genotoxicity Assessment
  • Ultrasound and Hyperthermia Applications
  • Metabolomics and Mass Spectrometry Studies
  • Lung Cancer Diagnosis and Treatment

Frequent collaborators in MacVittie's work include Ann M. Farese, Maureen A. Kane, Weiliang Huang, P. Artur Plett, and Jianshi Yu. These co-authors have contributed to multiple joint publications, indicating sustained collaborative research efforts.

Best Publications

  • Medical Management of the Acute Radiation Syndrome: Recommendations of the Strategic National Stockpile Radiation Working Group

    Jamie K. Waselenko;Thomas J. MacVittie;William F. Blakely;Nicki Pesik

  • Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock.

    C Natanson;P W Eichenholz;R L Danner;P Q Eichacker

  • Gram-negative bacteremia produces both severe systolic and diastolic cardiac dysfunction in a canine model that simulates human septic shock.

    C Natanson;M P Fink;H K Ballantyne;T J MacVittie

  • Role of endotoxemia in cardiovascular dysfunction and mortality. Escherichia coli and Staphylococcus aureus challenges in a canine model of human septic shock.

    C Natanson;R L Danner;R J Elin;J M Hosseini

  • Models for Evaluating Agents Intended for the Prophylaxis, Mitigation and Treatment of Radiation Injuries Report of an NCI Workshop, December 3–4, 2003

    Helen B. Stone;John E. Moulder;C. Norman Coleman;K. Kian Ang

  • Administration of interleukin-6 stimulates multilineage hematopoiesis and accelerates recovery from radiation-induced hematopoietic depression.

    ML Patchen;TJ MacVittie;JL Williams;GN Schwartz

  • Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony-stimulating factor enhances multilineage hematopoietic reconstitution in nonhuman primates after radiation-induced marrow aplasia.

    Ann M Farese;Pamela Hunt;Lisa B Grab;Thomas J MacVittie

  • The Soluble Form of IL-1 Receptor Accessory Protein Enhances the Ability of Soluble Type II IL-1 Receptor to Inhibit IL-1 Action

    Dirk E. Smith;Roberta Hanna;Della Friend;Heather Moore

  • Molecular and cellular biology of moderate-dose (1-10 Gy) radiation and potential mechanisms of radiation protection: report of a workshop at Bethesda, Maryland, December 17-18, 2001.

    C. Norman Coleman;William F. Blakely;John R. Fike;Thomas J. MacVittie

  • Rapid mobilization of murine hematopoietic stem cells with enhanced engraftment properties and evaluation of hematopoietic progenitor cell mobilization in rhesus monkeys by a single injection of SB-251353, a specific truncated form of the human CXC chemokine GROβ

    Andrew G. King;Dan Horowitz;Susan B. Dillon;Robert Levin

  • Establishing a murine model of the Hematopoietic Syndrome of the Acute Radiation Syndrome

    P. Artur Plett;Carol H. Sampson;Hui Lin Chua;Mandar Joshi

  • Role of cytokines (interleukin 1, tumor necrosis factor, and transforming growth factor beta) in natural and lipopolysaccharide-enhanced radioresistance

    R Neta;J J Oppenheim;R D Schreiber;R Chizzonite

  • Therapeutic use of recombinant human G-CSF (rhG-CSF) in a canine model of sublethal and lethal whole-body irradiation.

    T J MacVittie;R L Monroy;M L Patchen;L M Souza

  • Glucan: Mechanisms Involved in Its “Radioprotective” Effect

    M.L. Patchen;M.M. D'Alesandro;I. Brook;W.F. Blakely

  • Defining the full therapeutic potential of recombinant growth factors in the post radiation-accident environment: the effect of supportive care plus administration of G-CSF.

    Thomas J. Macvittie;Ann M. Farese;William Jackson

  • Efficient and durable gene marking of hematopoietic progenitor cells in nonhuman primates after nonablative conditioning

    M. Rosenzweig;T.J. MacVittie;D. Harper;D. Hempel

  • The effect of recombinant GM-CSF on the recovery of monkeys transplanted with autologous bone marrow

    RL Monroy;RR Skelly;TJ MacVittie;TA Davis

  • Animal models for acute radiation syndrome drug discovery.

    Vijay K Singh;Victoria L Newman;Allison N Berg;Thomas J MacVittie

  • NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation

    Jung Hyun Kim;Rajesh K. Thimmulappa;Vineet Kumar;Wanchang Cui

  • Role of endotoxemia in cardiovascular dysfunction and mortality: Escherichia coli and staphylococcus aureus challenges in a canine model of human septic shock

    C. Natanson;R.L. Danner;R.J. Elin

Frequent Co-Authors

Robert L. Danner
Robert L. Danner National Institutes of Health
Joseph E. Parrillo
Joseph E. Parrillo Hackensack University Medical Center
Barry P. Katz
Barry P. Katz Indiana University
Douglas E. Williams
Douglas E. Williams Codiak BioSciences
Ronald E. Gress
Ronald E. Gress National Institutes of Health
Alessio Fasano
Alessio Fasano Mead Johnson (United States)
Dean L. Mann
Dean L. Mann University of Maryland, Baltimore
Harry L. Malech
Harry L. Malech National Institutes of Health
Mitchell P. Fink
Mitchell P. Fink University of California, Los Angeles
David H. Sachs
David H. Sachs Columbia University

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