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Microbiology

D-Index
49
Citations
11849
World Ranking
4529
National Ranking
1748

Overview

Cynthia A. Derdeyn is affiliated with the University of Washington in the United States and focuses primarily on research in immunology, microbiology, and medicine.

Their research encompasses several subfields, including virology, immunology, infectious diseases, epidemiology, and molecular biology. The main topics of their work cover HIV research and treatment, immune cell function and interaction, T-cell and B-cell immunology, HIV/AIDS drug development and treatment, as well as research on cytomegalovirus, herpesvirus, and hepatitis C virus.

Among the recent papers authored or co-authored by Cynthia A. Derdeyn are the following:

  • Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells, 2020, Nature
  • T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers, 2020, Nature Medicine
  • The C3/465 glycan hole cluster in BG505 HIV-1 envelope is the major neutralizing target involved in preventing mucosal SHIV infection, 2021, PLoS Pathogens
  • Author Correction: Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells, 2020, Nature
  • Increased homeostatic cytokines and stability of HIV-infected memory CD4 T-cells identify individuals with suboptimal CD4 T-cell recovery on-ART, 2021, PLoS Pathogens

Frequent co-authors collaborating with Cynthia A. Derdeyn include:

  • Samantha L. Burton
  • Steven E. Bosinger
  • Mirko Paiardini
  • Tysheena P. Charles
  • Sailaja Gangadhara

The most common publication venues for their work are:

  • PLoS Pathogens
  • Journal of Medicinal Chemistry
  • UNC Libraries
  • Nature
  • Nature Medicine

Their research productivity spans a significant number of publications in immunology and microbiology with a strong emphasis on HIV/AIDS-related topics that explore virus-host interactions, immune responses, and vaccine development. This body of work includes experimental studies addressing viral reactivation, immune cell dynamics during infection, and mechanisms of immune evasion.

Best Publications

  • Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection.

    Jesus F. Salazar-Gonzalez;Maria G. Salazar;Brandon F. Keele;Gerald H. Learn

  • Sensitivity of Human Immunodeficiency Virus Type 1 to the Fusion Inhibitor T-20 Is Modulated by Coreceptor Specificity Defined by the V3 Loop of gp120

    Cynthia A. Derdeyn;Julie M. Decker;Jeffrey N. Sfakianos;Xiaoyun Wu

  • Envelope-Constrained Neutralization-Sensitive HIV-1 After Heterosexual Transmission

    Cynthia A. Derdeyn;Julie M. Decker;Frederic Bibollet-Ruche;John L. Mokili

  • Deciphering Human Immunodeficiency Virus Type 1 Transmission and Early Envelope Diversification by Single-Genome Amplification and Sequencing

    Jesus F. Salazar-Gonzalez;Elizabeth Bailes;Kimmy T. Pham;Maria G. Salazar

  • Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics

    Jacqueline D. Reeves;Stephen A. Gallo;Navid Ahmad;John L. Miamidian

  • Initial increase in blood CD4+ lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissues

    R. Pat Bucy;Richard D. Hockett;Cynthia A. Derdeyn;Michael S. Saag

  • Inflammatory genital infections mitigate a severe genetic bottleneck in heterosexual transmission of subtype A and C HIV-1.

    Richard E. Haaland;Paulina A. Hawkins;Jesus Salazar-Gonzalez;Amber Johnson

  • Antigenic conservation and immunogenicity of the HIV coreceptor binding site

    Julie M. Decker;Frederic Bibollet-Ruche;Xiping Wei;Shuyi Wang

  • Genetic and Neutralization Properties of Subtype C Human Immunodeficiency Virus Type 1 Molecular env Clones from Acute and Early Heterosexually Acquired Infections in Southern Africa

    Ming Li;Jesus F. Salazar-Gonzalez;Cynthia A. Derdeyn;Lynn Morris

  • Escape and Compensation from Early HLA-B57-Mediated Cytotoxic T-Lymphocyte Pressure on Human Immunodeficiency Virus Type 1 Gag Alter Capsid Interactions with Cyclophilin A

    Mark A. Brockman;Arne Schneidewind;Matthew Lahaie;Aaron Schmidt;Aaron Schmidt

  • Constant mean viral copy number per infected cell in tissues regardless of high, low, or undetectable plasma HIV RNA

    Richard D. Hockett;J. Michael Kilby;Cynthia A. Derdeyn;Michael S. Saag

  • Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients

    Paul A. Goepfert;Wendy Lumm;Paul Farmer;Philippa Matthews

  • Sensitivity of Human Immunodeficiency Virus Type 1 to Fusion Inhibitors Targeted to the gp41 First Heptad Repeat Involves Distinct Regions of gp41 and Is Consistently Modulated by gp120 Interactions with the Coreceptor

    Cynthia A. Derdeyn;Julie M. Decker;Jeffrey N. Sfakianos;Zhijun Zhang

  • Escape from autologous neutralizing antibodies in acute/early subtype C HIV-1 infection requires multiple pathways.

    Rong Rong;Bing Li;Rebecca M. Lynch;Rebecca M. Lynch;Richard E. Haaland;Richard E. Haaland

  • Molecular epidemiology of human immunodeficiency virus type 1 transmission in a heterosexual cohort of discordant couples in Zambia.

    Stanley A. Trask;Cynthia A. Derdeyn;Ulgen Fideli;Yalu Chen

  • Evidence for Potent Autologous Neutralizing Antibody Titers and Compact Envelopes in Early Infection with Subtype C Human Immunodeficiency Virus Type 1

    Bing Li;Julie M. Decker;Roy W. Johnson;Frederic Bibollet-Ruche;Frederic Bibollet-Ruche

  • CD8+ Lymphocytes Are Required for Maintaining Viral Suppression in SIV-Infected Macaques Treated with Short-Term Antiretroviral Therapy

    Emily K. Cartwright;Lori Spicer;S. Abigail Smith;David Lee

  • Role of V1V2 and Other Human Immunodeficiency Virus Type 1 Envelope Domains in Resistance to Autologous Neutralization during Clade C Infection

    Rong Rong;Frederic Bibollet-Ruche;Joseph Mulenga;Susan Allen

  • Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells.

    Julia Bergild McBrien;Maud Mavigner;Lavinia Franchitti;S. Abigail Smith

  • T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers.

    Prabhu S. Arunachalam;Tysheena P. Charles;Vineet Joag;Venkata S. Bollimpelli

  • after HIV antiretroviral therapy reflects redistribution from lymphoid tissues

    R. Pat Bucy;Richard D. Hockett;Cynthia A. Derdeyn;Michael S. Saag

Frequent Co-Authors

Eric Hunter
Eric Hunter Emory University
Susan Allen
Susan Allen Emory University
Guido Silvestri
Guido Silvestri Emory University
Rama Rao Amara
Rama Rao Amara Emory University
Mirko Paiardini
Mirko Paiardini Emory University
George M. Shaw
George M. Shaw University of Pennsylvania
Bette T. Korber
Bette T. Korber Los Alamos National Laboratory
Ronald G. Collman
Ronald G. Collman University of Pennsylvania
Bali Pulendran
Bali Pulendran Stanford University
Beatrice H. Hahn
Beatrice H. Hahn University of Pennsylvania

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