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Biology and Biochemistry

D-Index
57
Citations
9744
World Ranking
14019
National Ranking
5916

Overview

Carolyn E. Machamer is affiliated with Johns Hopkins University School of Medicine in the United States. Their research spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on several subfields including Infectious Diseases, Molecular Biology, Immunology, Pathology and Forensic Medicine, and Surgery.

Their work includes topics such as SARS-CoV-2 and COVID-19 Research, Cell death mechanisms and regulation, COVID-19 Clinical Research Studies, Complement system in diseases, Cancer Mechanisms and Therapy, Melanoma and MAPK Pathways, and Cholesterol and Lipid Metabolism.

Recent papers authored or coauthored by Carolyn E. Machamer include:

  • IgM anti-ACE2 autoantibodies in severe COVID-19 activate complement and perturb vascular endothelial function, 2022, JCI Insight
  • IgM autoantibodies recognizing ACE2 are associated with severe COVID-19, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum, 2020, Cell chemical biology
  • Evidence for the role of Rab11-positive recycling endosomes as intermediates in coronavirus egress from epithelial cells, 2022, Histochemistry and Cell Biology
  • Tumor MK2 transcript levels are associated with improved response to chemotherapy and patient survival in non-small cell lung cancer, 2023, Physiological Genomics

Frequently collaborating co-authors include Mahendra Damarla, Karthik Suresh, Othello Del Rosario, Medha Kallem, and Gayatri Singh.

Their publications frequently appear in venues such as bioRxiv (Cold Spring Harbor Laboratory), JCI Insight, Cell chemical biology, Histochemistry and Cell Biology, and Physiological Genomics.

Best Publications

  • Caspase-2 Is Localized at the Golgi Complex and Cleaves Golgin-160 during Apoptosis

    Marie Mancini;Carolyn E. Machamer;Sophie Roy;Donald W. Nicholson

  • Assembly of vaccinia virus: role of the intermediate compartment between the endoplasmic reticulum and the Golgi stacks.

    B. Sodeik;R.W. Doms;M. Ericsson;G. Hiller

  • Infectious Bronchitis Virus E Protein Is Targeted to the Golgi Complex and Directs Release of Virus-Like Particles

    Emily Corse;Carolyn E. Machamer

  • The Coronavirus E Protein: Assembly and Beyond

    Travis R. Ruch;Carolyn E. Machamer

  • Privileged delivery of polymer nanoparticles to the perinuclear region of live cells via a non-clathrin, non-degradative pathway.

    Samuel K. Lai;Kaoru Hida;Stan T. Man;Clive Chen

  • A specific transmembrane domain of a coronavirus E1 glycoprotein is required for its retention in the Golgi region.

    C E Machamer;J K Rose

  • Efficient Export of the Vesicular Stomatitis Virus G Protein from the Endoplasmic Reticulum Requires a Signal in the Cytoplasmic Tail That Includes Both Tyrosine-based and Di-acidic Motifs

    Carolyn S. Sevier;Ora A. Weisz;Mollie Davis;Carolyn E. Machamer

  • A Golgi retention signal in a membrane-spanning domain of coronavirus E1 protein.

    A M Swift;C E Machamer

  • The cytoplasmic tail of the severe acute respiratory syndrome coronavirus spike protein contains a novel endoplasmic reticulum retrieval signal that binds COPI and promotes interaction with membrane protein

    Corrin E. McBride;Jie Li;Carolyn E. Machamer

  • Differential effects of mutations in three domains on folding, quaternary structure, and intracellular transport of vesicular stomatitis virus G protein.

    R W Doms;A Ruusala;C Machamer;J Helenius

  • Vesicular stomatitis virus G proteins with altered glycosylation sites display temperature-sensitive intracellular transport and are subject to aberrant intermolecular disulfide bonding.

    Carolyn E Machamer;J. K. Rose

  • Golgi structure in stress sensing and apoptosis.

    Stuart W. Hicks;Carolyn E. Machamer

  • A single N-linked oligosaccharide at either of the two normal sites is sufficient for transport of vesicular stomatitis virus G protein to the cell surface.

    Carolyn E. Machamer;Robert Z. Florkiewicz;John K. Rose

  • Oligomerization of a membrane protein correlates with its retention in the Golgi complex

    Ora A. Weisz;Ann M. Swift;Carolyn E. Machamer

  • Intracellular Targeting Signals Contribute to Localization of Coronavirus Spike Proteins near the Virus Assembly Site

    Erik Lontok;Emily Corse;Carolyn E. Machamer

  • Glycosylation allows cell-surface transport of an anchored secretory protein.

    Jun Lin Guan;Jun Lin Guan;Carolyn E. Machamer;John K. Rose

  • Biosynthesis and glycosylation of the invariant chain associated with HLA-DR antigens.

    C E Machamer;P Cresswell

  • The cytoplasmic tails of infectious bronchitis virus E and M proteins mediate their interaction

    Emily Corse;Carolyn E Machamer

  • Ultrastructure and Regulation of Lateralized Connexin43 in the Failing Heart

    Geoffrey G. Hesketh;Manish H. Shah;Manish H. Shah;Victoria L. Halperin;Carol A. Cooke

  • Effects of a sphingolipid synthesis inhibitor on membrane transport through the secretory pathway

    Anne G. Rosenwald;Carolyn E. Machamer;Richard E. Pagano

Frequent Co-Authors

Peter Cresswell
Peter Cresswell Yale University
Antony Rosen
Antony Rosen Johns Hopkins University School of Medicine
Matthew B. Frieman
Matthew B. Frieman University of Maryland, Baltimore
Oliver Laeyendecker
Oliver Laeyendecker Johns Hopkins University
Larissa A. Shimoda
Larissa A. Shimoda Johns Hopkins University
Ronen Marmorstein
Ronen Marmorstein University of Pennsylvania
Livia Casciola-Rosen
Livia Casciola-Rosen Johns Hopkins University School of Medicine
Martin S. Taylor
Martin S. Taylor Harvard University
Jef D. Boeke
Jef D. Boeke New York University
Justin Hanes
Justin Hanes Johns Hopkins University

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