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Brendan A. Larder

Brendan A. Larder

D-Index & Metrics

Microbiology

D-Index
72
Citations
20365
World Ranking
1733
National Ranking
743

Overview

Brendan A. Larder is a researcher affiliated with Tibotec in the United States. Their work primarily falls within the fields of Medicine and Immunology and Microbiology, with a focus on subfields such as Infectious Diseases and Virology.

Larder's research addresses topics related to HIV, including HIV Research and Treatment, HIV/AIDS Research and Interventions, and the development of HIV/AIDS drugs and treatment strategies.

Their recent publication record includes the 2021 paper titled "2021 update to HIV-TRePS: a highly flexible and accurate system for the prediction of treatment response from incomplete baseline information in different healthcare settings", published in the Journal of Antimicrobial Chemotherapy. This work has been cited in subsequent research.

Frequent collaborators in Larder's research include:

  • Carlo Torti
  • Robin Wood
  • Dolphina Cogill
  • Hugo Tempelman
  • Raph L Hamers

Larder's work has appeared predominantly in the Journal of Antimicrobial Chemotherapy.

Best Publications

  • HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy

    Brendan A. Larder;Graham Darby;Douglas D. Richman

  • Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT).

    Brendan A. Larder;Sharon D. Kemp

  • Resistance to ddI and Sensitivity to AZT Induced by a Mutation in HIV-1 Reverse Transcriptase

    M. H. St. Clair;J. L. Martin;G. Tudor-Williams;G. Tudor-Williams;M. C. Bach

  • Potential mechanism for sustained antiretroviral efficacy of AZT-3TC combination therapy

    BA Larder;SD Kemp;PR Harrigan

  • Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase.

    Margaret Tisdale;Sharon D. Kemp;Nigel R. Parry;Brendan A. Larder

  • A Rapid Method for Simultaneous Detection of Phenotypic Resistance to Inhibitors of Protease and Reverse Transcriptase in Recombinant Human Immunodeficiency Virus Type 1 Isolates from Patients Treated with Antiretroviral Drugs

    Kurt Hertogs;Marie-Pierre de Béthune;Veronica Miller;Tania Ivens

  • Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine.

    Paul Kellam;Charles A. B. Boucher;Brendan A. Larder

  • Mutations in Retroviral Genes Associated with Drug Resistance

    John W. Mellors;Raymond F. Schinazi;Brendan A. Larder

  • Ordered appearance of zidovudine resistance mutations during treatment of 18 human immunodeficiency virus-positive subjects.

    Charles A. B. Boucher;Eithne O'Sullivan;Jan W. Mulder;Chitra Ramautarsing

  • Site-specific mutagenesis of AIDS virus reverse transcriptase.

    Brendan A. Larder;Dorothy J. M. Purifoy;Kenneth L. Powell;Graham Darby

  • Zidovudine resistance predicted by direct detection of mutations in DNA from HIV-infected lymphocytes.

    Brendan A. Larder;Paul Kellam;Sharon D. Kemp

  • Genotypic Correlates of Phenotypic Resistance to Efavirenz in Virus Isolates from Patients Failing Nonnucleoside Reverse Transcriptase Inhibitor Therapy

    Lee Bacheler;Susan Jeffrey;George Hanna;Richard D'Aquila

  • Related functional domains in virus DNA polymerases.

    B A Larder;S D Kemp;G Darby

  • Virological and immunological effects of treatment interruptions in HIV-1 infected patients with treatment failure

    Veronica Miller;Caroline Sabin;Kurt Hertogs;Stuart Bloor

  • 3'-Azido-3'-deoxythymidine resistance suppressed by a mutation conferring human immunodeficiency virus type 1 resistance to nonnucleoside reverse transcriptase inhibitors.

    B A Larder

  • Recombinant virus assay: a rapid, phenotypic assay for assessment of drug susceptibility of human immunodeficiency virus type 1 isolates.

    P Kellam;B A Larder

  • Phenotypic and genotypic analysis of clinical HIV-1 isolates reveals extensive protease inhibitor cross-resistance: a survey of over 6000 samples.

    K. Hertogs;S. Bloor;S. D. Kemp;C. van den Eynde

  • Relative Replicative Fitness of Zidovudine-Resistant Human Immunodeficiency Virus Type 1 Isolates In Vitro

    P. Richard Harrigan;Stuart Bloor;Brendan A. Larder

  • Susceptibilities of zidovudine-susceptible and -resistant human immunodeficiency virus isolates to antiviral agents determined by using a quantitative plaque reduction assay.

    B A Larder;B Chesebro;D D Richman

  • Quantitative detection of HIV-1 drug resistance mutations by automated DNA sequencing.

    B. A. Larder;A. Kohli;P. Kellam;S. D. Kemp

Frequent Co-Authors

Kurt Hertogs
Kurt Hertogs AZ Monica
Julio S. G. Montaner
Julio S. G. Montaner University of British Columbia
Charles A. Boucher
Charles A. Boucher Erasmus University Rotterdam
Robin Wood
Robin Wood University of Cape Town
Paul Kellam
Paul Kellam Imperial College London
Sean Emery
Sean Emery University of New South Wales
Douglas D. Richman
Douglas D. Richman University of California, San Diego
David K. Stammers
David K. Stammers University of Oxford
H. Clifford Lane
H. Clifford Lane National Institute of Allergy and Infectious Diseases
Veronica Miller
Veronica Miller University of California, Berkeley

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