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Medicine
Netherlands
2023
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Microbiology
Netherlands
2022

D-Index & Metrics

Microbiology

D-Index
98
Citations
32993
World Ranking
459
National Ranking
32

Medicine

D-Index
109
Citations
43889
World Ranking
5781
National Ranking
216

Research.com Recognitions

  • 2023 - Research.com Medicine in Netherlands Leader Award
  • 2022 - Research.com Microbiology in Netherlands Leader Award

Overview

Charles A. Boucher was affiliated with Erasmus University Rotterdam in the Netherlands. Their research spanned primarily medicine and immunology and microbiology, with a focus on infectious diseases, epidemiology, virology, molecular biology, and hepatology.

The scientist contributed to fields related to viral infections and immune response mechanisms, concentrating notably on HIV/AIDS and hepatitis research as well as SARS-CoV-2 and COVID-19. Their main topics of work included:

  • HIV/AIDS Research and Interventions
  • HIV Research and Treatment
  • HIV/AIDS drug development and treatment
  • Hepatitis B Virus Studies
  • HIV, Drug Use, Sexual Risk
  • Hepatitis C virus research
  • SARS-CoV-2 and COVID-19 Research

Charles A. Boucher published extensively, with recent papers demonstrating involvement in studies on infectious virus shedding, liver organoids for HBV infection, selective death of HIV-1-infected cells, and quality of life assessments among people living with HIV. Notable publications included:

  • "Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19)," 2021, Nature Communications
  • "Shedding of infectious virus in hospitalized patients with coronavirus disease-2019 (COVID-19): duration and key determinants," 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • "Application of human liver organoids as a patient-derived primary model for HBV infection and related hepatocellular carcinoma," 2021, eLife
  • "Selective cell death in HIV-1-infected cells by DDX3 inhibitors leads to depletion of the inducible reservoir," 2021, Nature Communications
  • "Quality of life among people living with HIV in England and the Netherlands: a population-based study," 2021, The Lancet Regional Health - Europe

Their research appeared frequently in several publication venues, including:

  • Viruses
  • Clinical Infectious Diseases
  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • AIDS Research and Human Retroviruses

Collaboration played a significant role in their work. Frequent co-authors included:

  • David van de Vijver
  • Annelies Verbon
  • Casper Rokx
  • Jeroen J. A. van Kampen
  • Stephanie Popping

Best Publications

  • Drug Resistance Mutations for Surveillance of Transmitted HIV-1 Drug-Resistance: 2009 Update

    Diane E. Bennett;Ricardo J. Camacho;Dan Otelea;Daniel R. Kuritzkes

  • Ordered accumulation of mutations in HIV protease confers resistance to ritonavir.

    Molla A;Korneyeva M;Gao Q;Vasavanonda S

  • Combining clinical and thallium data optimizes preoperative assessment of cardiac risk before major vascular surgery

    K.A. Eagle;C.M. Coley;J.B. Newell;D.C. Brewster

  • Determination of cardiac risk by dipyridamole-thallium imaging before peripheral vascular surgery.

    C A Boucher;D C Brewster;R C Darling;R D Okada

  • Drug-resistance genotyping in HIV-1 therapy: the VIRAD APT randomi sed controlled trial

    J. Durant;P. Clevenbergh;P. Halfon;P. Delgiudice

  • Technetium-99m Hexakis 2-Methoxyisobutyl Isonitrile: Human Biodistribution, Dosimetry, Safety, and Preliminary Comparison to Thallium-201 for Myocardial Perfusion Imaging

    F J Wackers;D S Berman;J Maddahi;D D Watson

  • Pathogenesis and Transmission of Swine-Origin 2009 A(H1N1) Influenza Virus in Ferrets

    Vincent J. Munster;Emmie de Wit;Judith M. A. van den Brand;Sander Herfst

  • Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19).

    Jeroen J. A. van Kampen;David A. M. C. van de Vijver;Pieter L. A. Fraaij;Bart L. Haagmans

  • A SHORT-TERM STUDY OF THE SAFETY, PHARMACOKINETICS, AND EFFICACY OF RITONAVIR, AN INHIBITOR OF HIV-1 PROTEASE

    Sven A. Danner;Andrew Carr;John M. Leonard;Leah M. Lehman

  • Rapid Changes in Human Immunodeficiency Virus Type 1 RNA Load and Appearance of Drug-Resistant Virus Populations in Persons Treated with Lamivudine (3TC)

    Rob Schuurman;Monique Nijhuis;Remko van Leeuwen;Pauline Schipper

  • Reduced replication of 3TC-resistant HIV-1 variants in primary cells due to a processivity defect of the reverse transcriptase enzyme.

    N K Back;M Nijhuis;W Keulen;C A Boucher

  • An automated genotyping system for analysis of HIV-1 and other microbial sequences

    Tulio De Oliveira;Koen Deforche;Sharon Cassol;Mika Salminen

  • Prevalence of Drug-Resistant HIV-1 Variants in Untreated Individuals in Europe: Implications for Clinical Management

    Annemarie M. J. Wensing;David A. van de Vijver;Gioacchino Angarano;Birgitta Åsjö

  • Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine.

    Paul Kellam;Charles A. B. Boucher;Brendan A. Larder

  • Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy.

    Monique Nijhuis;Rob Schuurman;Dorien de Jong;John Erickson

  • T-cell division in human immunodeficiency virus (HIV)-1 infection is mainly due to immune activation: a longitudinal analysis in patients before and during highly active antiretroviral therapy (HAART).

    M. D. Hazenberg;J. W. T. C. Stuart;S. A. Otto;J. C. C. Borleffs

  • Ordered appearance of zidovudine resistance mutations during treatment of 18 human immunodeficiency virus-positive subjects.

    Charles A. B. Boucher;Eithne O'Sullivan;Jan W. Mulder;Chitra Ramautarsing

  • Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection.

    M. D. Hazenberg;S. A. Otto;J. W. Cohen Stuart;M. C. Verschuren

  • High-level resistance to (-) enantiomeric 2'-deoxy-3'-thiacytidine in vitro is due to one amino acid substitution in the catalytic site of human immunodeficiency virus type 1 reverse transcriptase.

    C. A. B. Boucher;N. Cammack;P. Schipper;R. Schuurman

  • Clinical utility of HIV-1 genotyping and expert advice: the Havana trial.

    Cristina Tural;Lidia Ruiz;Christopher Holtzer;Jonathan Schapiro

Frequent Co-Authors

H. William Strauss
H. William Strauss Cornell University
Gerald M. Pohost
Gerald M. Pohost University of Southern California
David A. M. C. van de Vijver
David A. M. C. van de Vijver Erasmus University Rotterdam
Rob Schuurman
Rob Schuurman Utrecht University
Anne-Mieke Vandamme
Anne-Mieke Vandamme Rega Institute for Medical Research
Jan Albert
Jan Albert Karolinska Institute
Jaap Goudsmit
Jaap Goudsmit Harvard University
Annemarie M. J. Wensing
Annemarie M. J. Wensing Utrecht University
Peter C. Block
Peter C. Block Emory University
Martin Schutten
Martin Schutten Erasmus University Rotterdam

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