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Overview

Axel Le Cesne is affiliated with the Institut Gustave Roussy in France and has contributed extensively to the field of medicine, with a focus on oncology and sarcoma research. Their work spans a range of specialized subfields including pulmonary and respiratory medicine, surgery, rheumatology, and gastroenterology.

The primary area of Axel Le Cesne's research concentrates on sarcoma diagnosis and treatment. Additional key topics of their work include vascular tumors and angiosarcomas, gastrointestinal tumor research and treatment, cardiac tumors and thrombi, gastrointestinal disorders and treatments, gastric cancer management and outcomes, and lymphoma diagnosis and treatment.

Their recent notable publications include:

  • Bone sarcomas: ESMO-EURACAN-GENTURIS-ERN PaedCan Clinical Practice Guideline for diagnosis, treatment and follow-up, 2021, Annals of Oncology
  • Effect of Doxorubicin Plus Olaratumab vs Doxorubicin Plus Placebo on Survival in Patients With Advanced Soft Tissue Sarcomas, 2020, JAMA
  • Nationwide incidence of sarcomas and connective tissue tumors of intermediate malignancy over four years using an expert pathology review network, 2021, PLoS ONE
  • Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma Network, 2020, Annals of Oncology
  • Doxorubicin plus dacarbazine, doxorubicin plus ifosfamide, or doxorubicin alone as a first-line treatment for advanced leiomyosarcoma: A propensity score matching analysis from the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group, 2020, Cancer

Axel Le Cesne frequently collaborates with several researchers, including:

  • Jean-Yves Blay
  • Nicolas Penel
  • Antoîne Italiano
  • Olivier Mir
  • Emmanuelle Bompas

Their research is often published in journals such as:

  • Journal of Clinical Oncology
  • Annals of Oncology
  • ESMO Open
  • Clinical Cancer Research
  • European Journal of Cancer

Best Publications

  • Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial

    Winette T A Van Der Graaf;Jean Yves Blay;Sant P. Chawla;Dong Wan Kim

  • Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial

    George D Demetri;Peter Reichardt;Yoon-Koo Kang;Jean-Yves Blay

  • Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients

    François Ghiringhelli;Cedric Menard;Pierre Emmanuel Puig;Sylvain Ladoire

  • Soft tissue and visceral sarcomas: ESMO–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up†

    P.G. Casali;N. Abecassis;S. Bauer;R. Biagini

  • NCCN Task Force report: management of patients with gastrointestinal stromal tumor (GIST)--update of the NCCN clinical practice guidelines.

    George D. Demetri;Robert S. Benjamin;Charles D. Blanke;Jean Yves Blay

  • KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours

    Maria Debiec-Rychter;Raf Sciot;Axel Le Cesne;Marcus Schlemmer

  • Consensus meeting for the management of gastrointestinal stromal tumors Report of the GIST Consensus Conference of 20–21 March 2004, under the auspices of ESMO

    Jean Yves Blay;Sylvie Bonvalot;Paolo Casali;Haesun Choi

  • Pazopanib, a Multikinase Angiogenesis Inhibitor, in Patients With Relapsed or Refractory Advanced Soft Tissue Sarcoma: A Phase II Study From the European Organisation for Research and Treatment of Cancer―Soft Tissue and Bone Sarcoma Group (EORTC Study 62043)

    Stefan Sleijfer;Isabelle Ray-Coquard;Zsuzsa Papai;Axel Le Cesne

  • Eribulin versus dacarbazine in previously treated patients with advanced liposarcoma or leiomyosarcoma: a randomised, open-label, multicentre, phase 3 trial

    Patrick Schöffski;Sant Chawla;Robert G. Maki;Antoine Italiano

  • Lymphopenia as a Prognostic Factor for Overall Survival in Advanced Carcinomas, Sarcomas, and Lymphomas

    Isabelle Ray-Coquard;Claire Cropet;Martine Van Glabbeke;Catherine Sebban

  • Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study.

    Isabelle Ray-Coquard;Jean-Yves Blay;Antoine Italiano;Axel Le Cesne

  • Cutaneous side-effects of kinase inhibitors and blocking antibodies

    Caroline Robert;Jean-Charles Soria;Alain Spatz;Axel Le Cesne

  • Efficacy and Safety of Trabectedin in Patients With Advanced or Metastatic Liposarcoma or Leiomyosarcoma After Failure of Prior Anthracyclines and Ifosfamide: Results of a Randomized Phase II Study of Two Different Schedules

    George D. Demetri;Sant P. Chawla;Margaret von Mehren;Paul Ritch

  • Gastrointestinal stromal tumours: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up.

    P.G. Casali;N. Abecassis;S. Bauer;R. Biagini

  • Primary Retroperitoneal Sarcomas: A Multivariate Analysis of Surgical Factors Associated With Local Control

    Sylvie Bonvalot;Michel Rivoire;Marine Castaing;Eberhard Stoeckle

  • Imatinib mesylate (STI-571 Glivec, Gleevec) is an active agent for gastrointestinal stromal tumours, but does not yield responses in other soft-tissue sarcomas that are unselected for a molecular target. Results from an EORTC Soft Tissue and Bone Sarcoma Group phase II study.

    J Verweij;A van Oosterom;J.-Y Blay;I Judson

  • Soft tissue and visceral sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

    Paolo G. Casali;Jean-Yves Blay;Alexia Bertuzzi;Stefan Bielack

  • Efficacy of trabectedin (ecteinascidin-743) in advanced pretreated myxoid liposarcomas: a retrospective study

    Federica Grosso;Robin L. Jones;George D. Demetri;Ian R. Judson

  • Adjuvant chemotherapy with doxorubicin, ifosfamide, and lenograstim for resected soft-tissue sarcoma (EORTC 62931): a multicentre randomised controlled trial

    Penella J. Woll;Peter Reichardt;Axel Le Cesne;Sylvie Bonvalot

  • Consensus meeting for the management of gastrointestinal stromal tumors Report of the GIST Consensus Conference of 20-21 March 2004, under the auspices of ESMO (vol 16, pg 566, 2005)

    JY Blay;S Bonvalot;P Casali;H Choi

Frequent Co-Authors

Jean-Yves Blay
Jean-Yves Blay Claude Bernard University Lyon 1
Antoine Italiano
Antoine Italiano University of Bordeaux
Isabelle Ray-Coquard
Isabelle Ray-Coquard Claude Bernard University Lyon 1
Christine Chevreau
Christine Chevreau DuPont (United States)
François Bertucci
François Bertucci Aix-Marseille University
Paolo G. Casali
Paolo G. Casali University of Milan
Cécile Le Péchoux
Cécile Le Péchoux Institut Gustave Roussy
Jean-Michel Coindre
Jean-Michel Coindre University of Bordeaux
Alessandro Gronchi
Alessandro Gronchi University of Milan
Hans Gelderblom
Hans Gelderblom Leiden University Medical Center

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