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Biology and Biochemistry

D-Index
55
Citations
11762
World Ranking
14985
National Ranking
6270

Overview

Alan J. Tackett is affiliated with the University of Arkansas for Medical Sciences in the United States. Their research spans multiple scientific disciplines, focusing primarily on biochemistry, genetics, and molecular biology, with significant contributions also made in medicine.

The main fields of study for their work include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these areas, Tackett has focused on several subfields, such as:

  • Molecular Biology
  • Oncology
  • Immunology
  • Cancer Research
  • Pulmonary and Respiratory Medicine

Their research topics cover a variety of specialized themes including:

  • Epigenetics and DNA Methylation
  • Coccidia and coccidiosis research
  • Ubiquitin and proteasome pathways
  • Antimicrobial Peptides and Activities
  • Cancer Immunotherapy and Biomarkers
  • Protein Degradation and Inhibitors
  • RNA modifications and cancer

Alan J. Tackett has coauthored papers with several frequent collaborators, including:

  • Stephanie D. Byrum
  • Samuel G. Mackintosh
  • Aaron J. Storey
  • Brian Koss
  • Gang Greg Wang

Their research findings have been published primarily in the following venues:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Regular and Young Investigator Award Abstracts
  • SSRN Electronic Journal
  • UNC Libraries

Recent papers by Alan J. Tackett include the following:

  • Phase separation drives aberrant chromatin looping and cancer development, 2021, Nature
  • Anti-PD-1/L1 lead-in before MAPK inhibitor combination maximizes antitumor immunity and efficacy, 2021, Cancer Cell
  • Spaceflight induces oxidative damage to blood-brain barrier integrity in a mouse model, 2020, The FASEB Journal
  • Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Antitumor T-cell Immunity, 2020, Cancer Discovery
  • A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells, 2021, Cell chemical biology

This body of work reflects a focus on mechanisms related to cancer biology, immune response modulation, molecular pathways, and the molecular effects of environmental factors such as spaceflight on physiological barriers.

Best Publications

  • A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling

    Joanna Wysocka;Tomek Swigut;Hua Xiao;Thomas A. Milne

  • Physical Association and Coordinate Function of the H3 K4 Methyltransferase MLL1 and the H4 K16 Acetyltransferase MOF

    Yali Dou;Thomas A. Milne;Thomas A. Milne;Alan J. Tackett;Edwin R. Smith

  • Current state of melanoma diagnosis and treatment.

    Lauren E. Davis;Sara C. Shalin;Alan J. Tackett

  • DNA methylation on N(6)-adenine in mammalian embryonic stem cells.

    Tao P. Wu;Tao Wang;Matthew G. Seetin;Yongquan Lai

  • Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs

    Sean D. Taverna;Serge Ilin;Richard S. Rogers;Jason C. Tanny

  • Phase separation drives aberrant chromatin looping and cancer development

    Jeong Hyun Ahn;Eric S. Davis;Timothy A. Daugird;Shuai Zhao

  • Long-distance combinatorial linkage between methylation and acetylation on histone H3 N termini

    Sean D. Taverna;Beatrix M. Ueberheide;Beatrix M. Ueberheide;Yifan Liu;Alan J. Tackett;Alan J. Tackett

  • A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates

    Melissa A. Suter;Aishe Chen;Marie S. Burdine;Mahua Choudhury

  • Proteomic and genomic characterization of chromatin complexes at a boundary

    Alan J. Tackett;David J. Dilworth;David J. Dilworth;Megan J. Davey;Michael E. O’Donnell;Michael E. O’Donnell

  • I-DIRT, a general method for distinguishing between specific and nonspecific protein interactions.

    Alan J Tackett;Jeffrey A DeGrasse;Matthew D Sekedat;Marlene Oeffinger

  • Effects of ionizing radiation on the heart

    Marjan Boerma;Vijayalakshmi Sridharan;Xiao-Wen Mao;Gregory A. Nelson

  • Identification of Small Molecule Inhibitors of Jumonji AT-rich Interactive Domain 1B (JARID1B) Histone Demethylase by a Sensitive High Throughput Screen

    Joyce Sayegh;Jian Cao;Mike Ran Zou;Alfonso Morales

  • ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth

    Boyko S. Atanassov;Ryan D. Mohan;Xianjiang Lan;Xianghong Kuang

  • GINS motion reveals replication fork progression is remarkably uniform throughout the yeast genome

    Matthew D Sekedat;David Fenyö;Richard S Rogers;Alan J Tackett

  • The mobile nucleoporin Nup2p and chromatin-bound Prp20p function in endogenous NPC-mediated transcriptional control

    David J. Dilworth;David J. Dilworth;Alan J. Tackett;Richard S. Rogers;Eugene C. Yi

  • ChAP-MS: A Method for Identification of Proteins and Histone Posttranslational Modifications at a Single Genomic Locus

    Stephanie D. Byrum;Ana Raman;Sean D. Taverna;Alan J. Tackett

  • sarA-mediated repression of protease production plays a key role in the pathogenesis of Staphylococcus aureus USA300 isolates.

    Agnieszka K. Zielinska;Karen E. Beenken;Lara N. Mrak;Horace J. Spencer

  • Identification of the Major Phosphorylation Site in Bcl-xL Induced by Microtubule Inhibitors and Analysis of Its Functional Significance

    Meenakshi Upreti;Elena N. Galitovskaya;Rong Chu;Alan J. Tackett

  • Oxidation resistance 1 is a novel senolytic target

    Xin Zhang;Suping Zhang;Suping Zhang;Xingui Liu;Yingying Wang

  • A selective phenelzine analogue inhibitor of histone demethylase LSD1.

    Polina Prusevich;Jay H. Kalin;Shonoi A. Ming;Manuela Basso

Frequent Co-Authors

Brian T. Chait
Brian T. Chait Rockefeller University
C. David Allis
C. David Allis Rockefeller University
John D. Aitchison
John D. Aitchison University of Minnesota
Mark S. Smeltzer
Mark S. Smeltzer University of Arkansas for Medical Sciences
Deyou Zheng
Deyou Zheng Albert Einstein College of Medicine
Craig E. Cameron
Craig E. Cameron University of North Carolina at Chapel Hill
Michael P. Rout
Michael P. Rout Rockefeller University
Jian Jin
Jian Jin Icahn School of Medicine at Mount Sinai
Haitao Li
Haitao Li Tsinghua University
Sokrates T. Pantelides
Sokrates T. Pantelides Vanderbilt University

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