His primary areas of investigation include Biochemistry, Escherichia coli, Transfer RNA, Mutant and Stereochemistry. His study in Biochemistry concentrates on Translation, Methionine—tRNA ligase and Eukaryotic translation. Yves Mechulam interconnects Nucleic acid sequence, Crystal structure and Enzyme in the investigation of issues within Escherichia coli.
Yves Mechulam regularly links together related areas like Nonsense mutation in his Transfer RNA studies. His Mutant research is multidisciplinary, incorporating elements of Mutation and RNA. His studies deal with areas such as Crystallography, Helix and DNA nanotechnology, DNA as well as Stereochemistry.
His main research concerns Transfer RNA, Biochemistry, Escherichia coli, Stereochemistry and Enzyme. His biological study spans a wide range of topics, including Amino acid, Ribosome, Initiation factor and Mutant. His studies in Methionine, Translation, Eukaryotic translation, Methionine—tRNA ligase and Protein biosynthesis are all subfields of Biochemistry research.
His Escherichia coli study incorporates themes from Nucleic acid sequence, Mutagenesis and Nucleotide. His Stereochemistry research includes themes of Crystallography, Helix, Rossmann fold, Sulfolobus solfataricus and Protein structure. His studies in Enzyme integrate themes in fields like Moiety, Site-directed mutagenesis and Bacteria.
Yves Mechulam mainly focuses on Transfer RNA, Stereochemistry, G-quadruplex, Amino acid and Eukaryotic translation. The study incorporates disciplines such as Mutant and Ribosomal protein in addition to Transfer RNA. His Stereochemistry research is multidisciplinary, relying on both Nucleic acid and DHX36, Helicase.
In his research on the topic of G-quadruplex, Polymorphism, Crystallography and Crystal structure is strongly related with A-DNA. His study on Amino acid is covered under Biochemistry. The various areas that Yves Mechulam examines in his Eukaryotic translation study include Ribosome, 30S, Pyrococcus abyssi and Start codon.
Yves Mechulam mostly deals with DNA, G-quadruplex, Ribosomal RNA, Stereochemistry and Initiation factor. His research in Ribosomal RNA intersects with topics in Ribosome, Translation, Eukaryotic translation, Messenger RNA and Computational biology. His Stereochemistry research is multidisciplinary, incorporating perspectives in Aminoacyl tRNA synthetase, Serine, Rossmann fold, DNA ligase and Subfamily.
Aminoacyl tRNA synthetase is a subfield of Transfer RNA that Yves Mechulam investigates. With his scientific publications, his incorporates both Transfer RNA and Partition. His research integrates issues of Ribosomal protein, Pyrococcus abyssi, 30S, Open reading frame and Start codon in his study of Initiation factor.
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Methionine as translation start signal: A review of the enzymes of the pathway in Escherichia coli
T. Meinnel;Y. Mechulam;S. Blanquet.
Capturing the mutational landscape of the beta-lactamase TEM-1.
Hervé Jacquier;Hervé Jacquier;André Birgy;André Birgy;Hervé Le Nagard;Yves Mechulam.
Proceedings of the National Academy of Sciences of the United States of America (2013)
Disruption of the gene for Met-tRNA(fMet) formyltransferase severely impairs growth of Escherichia coli.
J M Guillon;Y Mechulam;J M Schmitter;S Blanquet.
Journal of Bacteriology (1992)
Crystal structure of methionyl-tRNAfMet transformylase complexed with the initiator formyl-methionyl-tRNAfMet.
Emmanuelle Schmitt;Michel Panvert;Sylvain Blanquet;Yves Mechulam.
The EMBO Journal (1998)
Crystal structure of Escherichia coli methionyl-tRNA synthetase highlights species-specific features.
Yves Mechulam;Emmanuelle Schmitt;Laurent Maveyraud;Charles Zelwer.
Journal of Molecular Biology (1999)
The large subunit of initiation factor aIF2 is a close structural homologue of elongation factors
Emmanuelle Schmitt;Sylvain Blanquet;Yves Mechulam.
The EMBO Journal (2002)
Nucleotides of tRNA governing the specificity of Escherichia coli methionyl-tRNAfMet formyltransferase
Jean-Michel Guillon;Thierry Meinnel;Yves Mechulam;Christine Lazennec.
Journal of Molecular Biology (1992)
Discovery of Escherichia coli methionyl-tRNA synthetase mutants for efficient labeling of proteins with azidonorleucine in vivo
I. Caglar Tanrikulu;Emmanuelle Schmitt;Yves Mechulam;William A. Goddard.
Proceedings of the National Academy of Sciences of the United States of America (2009)
Identification of an amino acid region supporting specific methionyl-tRNA synthetase: tRNA recognition.
Patrice Mellot;Yves Mechulam;Daniel Le Corre;Sylvain Blanquet.
Journal of Molecular Biology (1989)
Structure of a left-handed DNA G-quadruplex
Wan Jun Chung;Brahim Heddi;Emmanuelle Schmitt;Kah Wai Lim.
Proceedings of the National Academy of Sciences of the United States of America (2015)
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