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D-Index & Metrics

Biology and Biochemistry

D-Index
46
Citations
5899
World Ranking
19013
National Ranking
891

Overview

Yves Mechulam is affiliated with École Polytechnique in France, focusing primarily on research within Biochemistry, Genetics, and Molecular Biology. Their scholarly contributions encompass 51 publications in this broad field, with particular emphasis on Molecular Biology, where 47 of their works are situated. Additional research interests include Materials Chemistry, Biomedical Engineering, Genetics, and Cellular and Molecular Neuroscience.

The scientist's work extensively covers key topics related to RNA and protein synthesis mechanisms, with 30 publications addressing this area. Other significant topics of interest include RNA modifications and cancer (24 publications), RNA regulation and disease (8 publications), as well as DNA and nucleic acid chemistry and advanced biosensing and bioanalysis techniques (6 publications each). Enzyme structure and function and RNA research and splicing are also notable themes in their research portfolio.

Yves Mechulam has published several recent papers, highlighting ongoing contributions to molecular and cellular biology. These include:

  • "Cryo-EM study of an archaeal 30S initiation complex gives insights into evolution of translation initiation" (2020), Communications Biology
  • "Recent Advances in Archaeal Translation Initiation" (2020), Frontiers in Microbiology
  • "A millisecond passive micromixer with low flow rate, low sample consumption and easy fabrication" (2021), Scientific Reports
  • "Visualization of translation reorganization upon persistent ribosome collision stress in mammalian cells" (2024), Molecular Cell
  • "A novel minimal motif for left-handed G-quadruplex formation" (2021), Chemical Communications

The scientist frequently collaborates with several co-authors, including Emmanuelle Schmitt (19 collaborations), Christine Lazennec-Schurdevin (10 collaborations), Gabrielle Bourgeois (9 collaborations), Pierre-Damien Coureux (8 collaborations), and Ramy Kazan (5 collaborations).

Publication venues that feature Yves Mechulam's work with notable frequency include bioRxiv (Cold Spring Harbor Laboratory), hosting 5 publications, Nucleic Acids Research with 2 publications, and single publications in Molecular Cell, Communications Biology, and Frontiers in Microbiology.

Best Publications

  • Methionine as translation start signal: A review of the enzymes of the pathway in Escherichia coli

    T. Meinnel;Y. Mechulam;S. Blanquet

  • Capturing the mutational landscape of the beta-lactamase TEM-1.

    Hervé Jacquier;Hervé Jacquier;André Birgy;André Birgy;Hervé Le Nagard;Yves Mechulam

  • Disruption of the gene for Met-tRNA(fMet) formyltransferase severely impairs growth of Escherichia coli.

    J M Guillon;Y Mechulam;J M Schmitter;S Blanquet

  • Crystal structure of methionyl-tRNAfMet transformylase complexed with the initiator formyl-methionyl-tRNAfMet.

    Emmanuelle Schmitt;Michel Panvert;Sylvain Blanquet;Yves Mechulam

  • Discovery of Escherichia coli methionyl-tRNA synthetase mutants for efficient labeling of proteins with azidonorleucine in vivo

    I. Caglar Tanrikulu;Emmanuelle Schmitt;Yves Mechulam;William A. Goddard

  • Crystal structure of Escherichia coli methionyl-tRNA synthetase highlights species-specific features.

    Yves Mechulam;Emmanuelle Schmitt;Laurent Maveyraud;Charles Zelwer

  • The large subunit of initiation factor aIF2 is a close structural homologue of elongation factors

    Emmanuelle Schmitt;Sylvain Blanquet;Yves Mechulam

  • Nucleotides of tRNA governing the specificity of Escherichia coli methionyl-tRNAfMet formyltransferase

    Jean-Michel Guillon;Thierry Meinnel;Yves Mechulam;Christine Lazennec

  • Structure of a left-handed DNA G-quadruplex

    Wan Jun Chung;Brahim Heddi;Emmanuelle Schmitt;Kah Wai Lim

  • Identification of an amino acid region supporting specific methionyl-tRNA synthetase: tRNA recognition.

    Patrice Mellot;Yves Mechulam;Daniel Le Corre;Sylvain Blanquet

  • Fast purification of a functional elongator tRNAmet expressed from a synthetic gene in vivo

    Thierry Meinnel;Yves Mechulam;Guy Fayat

  • Crystal structure at 1.2 Å resolution and active site mapping of Escherichia coli peptidyl-tRNA hydrolase

    Emmanuelle Schmitt;Yves Mechulam;Michel Fromant;Pierre Plateau

  • Sequence of the Escherichia coli pheST operon and identification of the himA gene.

    Y Mechulam;G Fayat;S Blanquet

  • Eukaryotic and archaeal translation initiation factor 2: a heterotrimeric tRNA carrier.

    Emmanuelle Schmitt;Marie Naveau;Yves Mechulam

  • Structural basis of RNA-dependent recruitment of glutamine to the genetic code

    Hiroyuki Oshikane;Kelly Sheppard;Shuya Fukai;Yuko Nakamura

  • Selection of suppressor methionyl-tRNA synthetases: mapping the tRNA anticodon binding site.

    T Meinnel;Y Mechulam;D Le Corre;M Panvert

  • Structure of an archaeal heterotrimeric initiation factor 2 reveals a nucleotide state between the GTP and the GDP states

    Laure Yatime;Yves Mechulam;Sylvain Blanquet;Emmanuelle Schmitt

  • Functional molecular mapping of archaeal translation initiation factor 2.

    Laure Yatime;Emmanuelle Schmitt;Sylvain Blanquet;Yves Mechulam

  • Structural and biochemical characterization of the Escherichia coli argE gene product.

    T Meinnel;E Schmitt;Y Mechulam;S Blanquet

  • Structure of crystalline Escherichia coli methionyl-tRNA(f)Met formyltransferase: comparison with glycinamide ribonucleotide formyltransferase.

    E Schmitt;S Blanquet;Y Mechulam

Frequent Co-Authors

Sylvain Blanquet
Sylvain Blanquet École Polytechnique
Thierry Meinnel
Thierry Meinnel University of Paris-Saclay
Anh Tuân Phan
Anh Tuân Phan Nanyang Technological University
Christine Petit
Christine Petit Université Paris Cité
Andre Mitschler
Andre Mitschler University of Strasbourg
Dino Moras
Dino Moras Institute of Genetics and Molecular and Cellular Biology
Osamu Nureki
Osamu Nureki University of Tokyo
Olivier Tenaillon
Olivier Tenaillon Université Paris Cité
David A. Tirrell
David A. Tirrell California Institute of Technology
Patrice Courvalin
Patrice Courvalin Institut Pasteur

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