World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
99
Citations
37872
World Ranking
1322
National Ranking
508

Research.com Recognitions

  • 2018 - Fellow, National Academy of Inventors
  • 2011 - Member of the National Academy of Medicine (NAM)
  • 2010 - Fellow of the American Chemical Society
  • 2008 - Member of the National Academy of Engineering For pioneering contributions to bioengineered materials and the synthesis of novel artificial proteins.
  • 2006 - Member of the National Academy of Sciences
  • 2005 - Fellow of the American Academy of Arts and Sciences
  • 2003 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1995 - Fellow of the Indian National Academy of Engineering (INAE)
  • 1982 - Fellow of Alfred P. Sloan Foundation

Overview

David A. Tirrell is affiliated with the California Institute of Technology in the United States. Their research spans primarily across the fields of Biochemistry, Genetics, and Molecular Biology, with significant contributions in Medicine. Subfields of focus include Molecular Biology, Surgery, Biomedical Engineering, Genetics, and Biophysics.

The scientist's work addresses several main topics, such as pancreatic function and diabetes, biochemical and structural characterization, bacterial biofilms and quorum sensing, chemical synthesis and analysis, glycosylation and glycoproteins research, 3D printing in biomedical research, and pancreatic and hepatic oncology research.

Frequent publication venues for the scientist include:

  • ACS Synthetic Biology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Frontiers in Bioengineering and Biotechnology
  • Methods in Enzymology on CD-ROM/Methods in Enzymology
  • ACS Chemical Biology

The scientist has collaborated repeatedly with several coauthors, including:

  • Hsun Teresa Ku
  • Mark T. Kozlowski
  • Janine C. Quijano
  • Heather N. Zook
  • Stephanie L. Breunig

Notable recent papers by David A. Tirrell include:

  • "Genetically Programmable Microbial Assembly," 2021, published in ACS Synthetic Biology
  • "A matrigel-free method for culture of pancreatic endocrine-like cells in defined protein-based hydrogels," 2023, published in Frontiers in Bioengineering and Biotechnology
  • "Incorporation of proline analogs into recombinant proteins expressed in Escherichia coli," 2021, published in Methods in Enzymology on CD-ROM/Methods in Enzymology
  • "Staphylococcalsecreted cytotoxins are competition sensing signals for Pseudomonas aeruginosa," 2023, published in bioRxiv (Cold Spring Harbor Laboratory)
  • "Incorporation of Aliphatic Proline Residues into Recombinantly Produced Insulin," 2023, published in ACS Chemical Biology

David A. Tirrell's recognition in the scientific community is reflected through multiple awards and fellowships:

  • Fellow, National Academy of Inventors, 2018
  • Member of the National Academy of Medicine (NAM), 2011
  • Fellow of the American Chemical Society, 2010
  • Member of the National Academy of Engineering, 2008, for pioneering contributions to bioengineered materials and the synthesis of novel artificial proteins
  • Member of the National Academy of Sciences, 2006
  • Fellow of the American Academy of Arts and Sciences, 2005
  • Fellow of the American Association for the Advancement of Science (AAAS), 2003
  • Fellow of the Indian National Academy of Engineering (INAE), 1995
  • Fellow of Alfred P. Sloan Foundation, 1982

Best Publications

  • Designing materials for biology and medicine

    Robert Langer;David A. Tirrell

  • Reversible Hydrogels from Self-Assembling Artificial Proteins

    Wendy A. Petka;James L. Harden;Kevin P. McGrath;Denis Wirtz

  • Microcalorimetric detection of lower critical solution temperatures in aqueous polymer solutions

    Howard G. Schild;David A. Tirrell

  • Incorporation of azides into recombinant proteins for chemoselective modification by the Staudinger ligation

    Kristi L. Kiick;Eliana Saxon;David A. Tirrell;Carolyn R. Bertozzi

  • Selective identification of newly synthesized proteins in mammalian cells using bioorthogonal noncanonical amino acid tagging (BONCAT)

    Daniela C. Dieterich;A. James Link;Johannes Graumann;David A. Tirrell

  • Cell surface labeling of Escherichia coli via copper(I)-catalyzed [3+2] cycloaddition.

    A. James Link;David A. Tirrell

  • Cononsolvency in mixed aqueous solutions of poly(N-isopropylacrylamide)

    Howard G. Schild;M. Muthukumar;David A. Tirrell

  • Protein-based materials, toward a new level of structural control

    Jan C. M. van Hest;David A. Tirrell

  • The design and synthesis of polymers for eukaryotic membrane disruption

    Niren Murthy;John R Robichaud;David A Tirrell;Patrick S Stayton

  • Non-canonical amino acids in protein engineering.

    A James Link;Marissa L Mock;David A Tirrell

  • Efficient incorporation of unsaturated methionine analogues into proteins in vivo

    Jan C. M. van Hest;Kristi L. Kiick;David A. Tirrell

  • Presentation and detection of azide functionality in bacterial cell surface proteins.

    A. James Link;Mandy K. S. Vink;David A. Tirrell

  • Calcium carbonate films and helices grown in solutions of poly(aspartate)

    L.A Gower;D.A Tirrell

  • Chemical sequence control of beta-sheet assembly in macromolecular crystals of periodic polypeptides

    Mark T. Krejchi;Edward D. T. Atkins;Alan J. Waddon;Maurille J. Fournier

  • Core-clickable PEG-branch-azide bivalent-bottle-brush polymers by ROMP: grafting-through and clicking-to.

    Jeremiah A. Johnson;Ying Y. Lu;Alan O. Burts;Yeon-Hee Lim

  • Labeling, detection and identification of newly synthesized proteomes with bioorthogonal non-canonical amino-acid tagging

    Daniela C Dieterich;Jennifer J Lee;A James Link;A James Link;Johannes Graumann;Johannes Graumann

  • Residue-specific incorporation of non-canonical amino acids into proteins: recent developments and applications.

    Jeremiah A Johnson;Ying Y Lu;James A Van Deventer;David A Tirrell

  • Drug-Loaded, Bivalent-Bottle-Brush Polymers by Graft-through ROMP

    Jeremiah A. Johnson;Ying Y. Lu;Alan O. Burts;Yan Xia

  • Fluorinated Coiled‐Coil Proteins Prepared In Vivo Display Enhanced Thermal and Chemical Stability

    Yi Tang;Giovanna Ghirlanda;Wendy A. Petka;Tadashi Nakajima

  • Fluorescence visualization of newly synthesized proteins in mammalian cells.

    Kimberly E. Beatty;Julie C. Liu;Fang Xie;Daniela C. Dieterich

  • Biomembrane Templates for Nanoscale Conduits and Networks

    Evan Evans;Howard Bowman;Andrew Leung;David Needham

Frequent Co-Authors

Maurille J. Fournier
Maurille J. Fournier University of Massachusetts Amherst
Yi Tang
Yi Tang University of California, Los Angeles
Kristi L. Kiick
Kristi L. Kiick University of Delaware
Patrick S. Stayton
Patrick S. Stayton University of Washington
Jan C. M. van Hest
Jan C. M. van Hest Eindhoven University of Technology
Erin M. Schuman
Erin M. Schuman Max Planck Society
Niren Murthy
Niren Murthy University of California, Berkeley
Lawrence A. Crum
Lawrence A. Crum University of Washington
Sarah C. Heilshorn
Sarah C. Heilshorn Stanford University
Timothy J. Deming
Timothy J. Deming University of California, Los Angeles

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