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Chemistry
Netherlands
2025

D-Index & Metrics

Materials Science

D-Index
91
Citations
30272
World Ranking
1612
National Ranking
19

Chemistry

D-Index
90
Citations
30072
World Ranking
2061
National Ranking
49

Research.com Recognitions

  • 2025 - Research.com Chemistry in Netherlands Leader Award
  • 2022 - Research.com Chemistry in Netherlands Leader Award
  • 2019 - Royal Netherlands Academy of Arts and Sciences

Overview

Jan C. M. van Hest is affiliated with Eindhoven University of Technology in the Netherlands. Their research spans multiple disciplines, primarily focusing on Biochemistry, Genetics and Molecular Biology, Materials Science, and Engineering. These broad areas incorporate several specialized subfields, including Molecular Biology, Biomedical Engineering, Biomaterials, Organic Chemistry, and Materials Chemistry.

The scientist's work addresses several key topics in contemporary research, involving:

  • Nanoplatforms for cancer theranostics
  • Micro and Nano Robotics
  • Nanoparticle-Based Drug Delivery
  • Supramolecular Self-Assembly in Materials
  • Molecular Communication and Nanonetworks
  • Advanced Polymer Synthesis and Characterization
  • Advanced biosensing and bioanalysis techniques

Jan C. M. van Hest has published extensively in high-impact scientific journals. Frequent publication venues include:

  • Angewandte Chemie International Edition
  • Nature Communications
  • Angewandte Chemie
  • Biomacromolecules
  • Journal of the American Chemical Society

Some recent representative papers include:

  • "Acid-Activatable Transmorphic Peptide-Based Nanomaterials for Photodynamic Therapy," 2020, Angewandte Chemie International Edition
  • "Intercellular communication between artificial cells by allosteric amplification of a molecular signal," 2020, Nature Communications
  • "Photoactivated nanomotors via aggregation induced emission for enhanced phototherapy," 2021, Nature Communications
  • "Exploring the Impact of Morphology on the Properties of Biodegradable Nanoparticles and Their Diffusion in Complex Biological Medium," 2020, Biomacromolecules
  • "Surface-Charge-Switchable Nanoclusters for Magnetic Resonance Imaging-Guided and Glutathione Depletion-Enhanced Photodynamic Therapy," 2020, ACS Nano

Collaborations form an important part of Jan C. M. van Hest's work. Frequent co-authors include Loai K. E. A. Abdelmohsen, Yudong Li, Shoupeng Cao, Jingxin Shao, and Hanglong Wu.

In recognition of their scientific contributions, Jan C. M. van Hest was awarded membership in the Royal Netherlands Academy of Arts and Sciences in 2019.

Best Publications

  • Readily Accessible Bicyclononynes for Bioorthogonal Labeling and Three‐Dimensional Imaging of Living Cells

    Jan Dommerholt;Samuel Schmidt;Rinske Temming;Linda J. A. Hendriks

  • Modular synthesis of block copolymers via cycloaddition of terminal azide and alkyne functionalized polymers.

    Joost A. Opsteen;Jan C. M. van Hest

  • Artificial cells: synthetic compartments with life-like functionality and adaptivity

    Bastiaan C. Buddingh;Jan C. M. van Hest

  • Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition.

    Marjoke F. Debets;Sander S. van Berkel;Sanne Schoffelen;Floris P. J. T. Rutjes

  • Sub‐Micron Polymeric Stomatocytes as Promising Templates for Confined Crystallization and Diffraction Experiments

    Alaa Adawy;Zakariae Amghouz;Jan C. M. van Hest;Daniela A. Wilson

  • Autonomous movement of platinum-loaded stomatocytes

    Daniela A. Wilson;Roeland J. M. Nolte;Jan C. M. van Hest

  • Cascade Reactions in Multicompartmentalized Polymersomes

    Ruud J.R.W. Peters;Maïté Marguet;Maïté Marguet;Sébastien Marais;Marco W. Fraaije

  • Protein-based materials, toward a new level of structural control

    Jan C. M. van Hest;David A. Tirrell

  • Polystyrene-Dendrimer Amphiphilic Block Copolymers with a Generation-Dependent Aggregation

    J. C. M. van Hest;D. A. P. Delnoye;M. W. P. L. Baars;M. H. P. van Genderen

  • Peptide- and Protein-Based Hydrogels

    Anika M. Jonker;Dennis W. P. M. Löwik;Jan C. M. van Hest

  • Positional assembly of enzymes in polymersome nanoreactors for cascade reactions.

    Dennis M. Vriezema;Paula M. L. Garcia;Paula M. L. Garcia;Nfflria Sancho Oltra;Nfflria Sancho Oltra;Nikos S. Hatzakis

  • The chemistry of tissue adhesive materials

    Petra J.M. Bouten;Petra J.M. Bouten;Marleen Zonjee;Johan Bender;Simon T.K. Yauw

  • Efficient incorporation of unsaturated methionine analogues into proteins in vivo

    Jan C. M. van Hest;Kristi L. Kiick;David A. Tirrell

  • Polymeric vesicles in biomedical applications

    René P. Brinkhuis;Floris P. J. T. Rutjes;Jan C. M. van Hest

  • Biohybrid Polymer Capsules

    Stijn F. M. van Dongen;Hans-Peter M. de Hoog;Ruud J. R. W. Peters;Madhavan Nallani

  • A Three-Enzyme Cascade Reaction through Positional Assembly of Enzymes in a Polymersome Nanoreactor

    Stijn F.M. van Dongen;Madhavan Nallani;Jeroen Johannes Lambertus Maria Cornelissen;Roeland J.M. Nolte

  • A Polymersome Nanoreactor with Controllable Permeability Induced by Stimuli-Responsive Block Copolymers

    Kyoung Taek Kim;Jeroen Johannes Lambertus Maria Cornelissen;Roeland J.M. Nolte;Jan C.M. van Hest

  • Stimulus responsive peptide based materials.

    Dennis W. P. M. Löwik;E. H. P. Leunissen;M. van den Heuvel;M. B. Hansen

  • Staudinger ligation as a method for bioconjugation.

    Sander S. van Berkel;Mark B. van Eldijk;Jan C. M. van Hest

  • Self-propelled supramolecular nanomotors with temperature-responsive speed regulation

    Yingfeng Tu;Fei Peng;Xiaofeng Sui;Yongjun Men

Frequent Co-Authors

Floris P. J. T. Rutjes
Floris P. J. T. Rutjes Radboud University
Roeland J. M. Nolte
Roeland J. M. Nolte Radboud University
David S. Williams
David S. Williams University of California, Los Angeles
Jeroen J. L. M. Cornelissen
Jeroen J. L. M. Cornelissen University of Twente
Daniela A. Wilson
Daniela A. Wilson Radboud University
Floris L. van Delft
Floris L. van Delft Wageningen University & Research
Alan E. Rowan
Alan E. Rowan University of Queensland
Sander C. G. Leeuwenburgh
Sander C. G. Leeuwenburgh Radboud University
Han Zuilhof
Han Zuilhof Wageningen University & Research
Richard Hoogenboom
Richard Hoogenboom Ghent University

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