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Chemistry

D-Index
55
Citations
10794
World Ranking
12129
National Ranking
226

Overview

Floris L. van Delft is affiliated with Wageningen University & Research in the Netherlands. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant work in related subfields such as Radiology, Nuclear Medicine and Imaging, Oncology, Molecular Biology, Organic Chemistry, and Materials Chemistry.

The main topics of their research include:

  • Monoclonal and Polyclonal Antibodies Research
  • CAR-T cell therapy research
  • Click Chemistry and Applications
  • Glycosylation and Glycoproteins Research
  • HER2/EGFR in Cancer Research
  • Radiopharmaceutical Chemistry and Applications
  • Immune Cell Function and Interaction

Among frequent co-authors collaborating with Floris L. van Delft are:

  • Remon van Geel
  • Bauke Albada
  • Han Zuilhof
  • Johannes A. M. Damen
  • Lianne P. W. M. Lelieveldt

Their publications have appeared in several notable academic venues, with multiple contributions to:

  • Cancer Research
  • Bioconjugate Chemistry
  • Chemical Reviews
  • mAbs
  • Chemistry - A European Journal

Recent papers authored or co-authored by Floris L. van Delft include:

  • "Oxidation-Induced 'One-Pot' Click Chemistry," 2021, Chemical Reviews
  • "Enzymatic glycan remodeling-metal free click (GlycoConnect™) provides homogenous antibody-drug conjugates with improved stability and therapeutic index without sequence engineering," 2022, mAbs
  • "Non-Genetic Generation of Antibody Conjugates Based on Chemoenzymatic Tyrosine Click Chemistry," 2021, Bioconjugate Chemistry
  • "Generation of DAR1 Antibody-Drug Conjugates for Ultrapotent Payloads Using Tailored GlycoConnect Technology," 2023, Bioconjugate Chemistry
  • "High Rates of Quinone-Alkyne Cycloaddition Reactions are Dictated by Entropic Factors," 2023, Chemistry - A European Journal

Best Publications

  • Readily Accessible Bicyclononynes for Bioorthogonal Labeling and Three‐Dimensional Imaging of Living Cells

    Jan Dommerholt;Samuel Schmidt;Rinske Temming;Linda J. A. Hendriks

  • Bioconjugation with strained alkenes and alkynes.

    Marjoke F. Debets;Sander S. van Berkel;Jan Dommerholt;A. (Ton) J. Dirks

  • Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition.

    Marjoke F. Debets;Sander S. van Berkel;Sanne Schoffelen;Floris P. J. T. Rutjes

  • Strain-Promoted 1,3-Dipolar Cycloaddition of Cycloalkynes and Organic Azides

    Jan Dommerholt;Floris P. J. T. Rutjes;Floris L. van Delft

  • Preventing thiol-yne addition improves the specificity of strain-promoted azide-alkyne cycloaddition

    Remon van Geel;Ger J M Pruijn;Floris L van Delft;Wilbert C Boelens

  • Azide: a unique dipole for metal-free bioorthogonal ligations.

    Marjoke F. Debets;Christianus W. J. van der Doelen;Floris P. J. T. Rutjes;Floris L. van Delft

  • Protein Modification by Strain-Promoted Alkyne–Nitrone Cycloaddition

    Xinghai Ning;Rinske P. Temming;Jan Dommerholt;Jun Guo

  • Metal‐Free Triazole Formation as a Tool for Bioconjugation

    Sander S. van Berkel;A. (Ton) J. Dirks;Marjoke F. Debets;Floris L. van Delft

  • Chemoenzymatic Conjugation of Toxic Payloads to the Globally Conserved N-Glycan of Native mAbs Provides Homogeneous and Highly Efficacious Antibody-Drug Conjugates.

    Remon van Geel;Marloes A. Wijdeven;Ryan Heesbeen;Jorge M. M. Verkade

  • Highly accelerated inverse electron-demand cycloaddition of electron-deficient azides with aliphatic cyclooctynes

    Jan Dommerholt;Olivia van Rooijen;Annika Borrmann;Célia Fonseca Guerra

  • Targeting Aberrant Sialylation in Cancer Cells Using a Fluorinated Sialic Acid Analog Impairs Adhesion, Migration, and In Vivo Tumor Growth

    Christian Büll;Thomas J. Boltje;Melissa Wassink;Annemarie M.A. de Graaf

  • Synthesis of isoxazoles by hypervalent iodine-induced cycloaddition of nitrile oxides to alkynes

    Anup M. Jawalekar;Erik Reubsaet;Floris P. J. T. Rutjes;Floris L. van Delft

  • In situ phosphine oxide reduction: a catalytic Appel reaction.

    Henri A. van Kalkeren;Stefan H. A. M. Leenders;C. Rianne A. Hommersom;Floris P. J. T. Rutjes

  • Preparation of biohybrid amphiphiles via the copper catalysed Huisgen [3 + 2] dipolar cycloaddition reaction

    A. J. (Ton) Dirks;Sander S. van Berkel;Nikos S. Hatzakis;Joost A. Opsteen

  • Genetic encoding of a bicyclo[6.1.0]nonyne-charged amino acid enables fast cellular protein imaging by metal-free ligation

    Annika Borrmann;Sigrid Milles;Tilman Plass;Jan Dommerholt

  • 2-Deoxystreptamine : Central scaffold of aminoglycoside antibiotics

    Guuske F. Busscher;Floris P. J. T. Rutjes;Floris L. van Delft

  • Mild and efficient deprotection of the amine protecting p-methoxyphenyl (PMP) group

    Jorge M.M. Verkade;Lieke J.C. van Hemert;Peter J.L.M. Quaedflieg;Paul L. Alsters

  • Organophosphorus-Catalysed Staudinger Reduction

    Henri A. van Kalkeren;Jorick J. Bruins;Floris P. J. T. Rutjes;Floris L. van Delft

  • Total Synthesis of Eleutherobin

    K. C. Nicolaou;K. C. Nicolaou;Floris van Delft;Floris van Delft;Takashi Ohshima;Takashi Ohshima;Dionisios Vourloumis;Dionisios Vourloumis

  • Conjugation of Nucleosides and Oligonucleotides by [3+2] Cycloaddition

    Anup M. Jawalekar;Nico Meeuwenoord;J. (Sjef) G. O. Cremers;Herman S. Overkleeft

  • Expedient Synthesis of Triazole-Linked Glycosyl Amino Acids and Peptides.

    Brian H. M. Kuijpers;Stan Groothuys;A. R. Keereweer;Peter J. L. M. Quaedflieg

Frequent Co-Authors

Floris P. J. T. Rutjes
Floris P. J. T. Rutjes Radboud University
Jan C. M. van Hest
Jan C. M. van Hest Eindhoven University of Technology
Han Zuilhof
Han Zuilhof Wageningen University & Research
K. C. Nicolaou
K. C. Nicolaou Rice University
Hans E. Schoemaker
Hans E. Schoemaker DSM (Netherlands)
Wim J.G. Oyen
Wim J.G. Oyen Humanitas University
Jeroen J. L. M. Cornelissen
Jeroen J. L. M. Cornelissen University of Twente
Toin H. van Kuppevelt
Toin H. van Kuppevelt Radboud University
Alan E. Rowan
Alan E. Rowan University of Queensland
Roeland J. M. Nolte
Roeland J. M. Nolte Radboud University

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