Yousuke Takahama

Best Publications

• Journey through the thymus: stromal guides for T-cell development and selection

  Yousuke Takahama

  948
  Citations

• Regulation of CD8+ T Cell Development by Thymus-Specific Proteasomes

  Shigeo Murata;Katsuhiro Sasaki;Toshihiko Kishimoto;Shin-ichiro Niwa

  740
  Citations

• The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.

  Taishin Akiyama;Yusuke Shimo;Hiromi Yanai;Junwen Qin

  581
  Citations

• CCR7 Signals Are Essential for Cortex–Medulla Migration of Developing Thymocytes

  Tomoo Ueno;Fumi Saito;Daniel Herbert Donald Gray;Sachiyo Kuse

  537
  Citations

• The Cytokine RANKL Produced by Positively Selected Thymocytes Fosters Medullary Thymic Epithelial Cells that Express Autoimmune Regulator

  Yu Hikosaka;Takeshi Nitta;Izumi Ohigashi;Kouta Yano

  490
  Citations

• Thymic epithelial cells: working class heroes for T cell development and repertoire selection

  Graham Anderson;Yousuke Takahama

  434
  Citations

• CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance.

  Hirotsugu Kurobe;Cunlan Liu;Tomoo Ueno;Tomoo Ueno;Fumi Saito

  367
  Citations

• Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28

  J A Punt;B A Osborne;Y Takahama;S O Sharrow

  361
  Citations

• Development of Autoimmunity against Transcriptionally Unrepressed Target Antigen in the Thymus of Aire-Deficient Mice

  Noriyuki Kuroda;Tasuku Mitani;Naoki Takeda;Naozumi Ishimaru

  353
  Citations

• Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development

  Yu Lei;Yu Lei;Adiratna Mat Ripen;Naozumi Ishimaru;Izumi Ohigashi

  348
  Citations

• Differential Roles of ERK and p38 MAP Kinase Pathways in Positive and Negative Selection of T Lymphocytes

  Takehiko Sugawara;Tetsuo Moriguchi;Eisuke Nishida;Yousuke Takahama

  328
  Citations

• Role for CCR7 Ligands in the Emigration of Newly Generated T Lymphocytes from the Neonatal Thymus

  Tomoo Ueno;Kyoko Hara;Melissa S Willis;M A Malin

  310
  Citations

• A Role for Pref-1 and HES-1 in Thymocyte Development

  Midori Kaneta;Masatake Osawa;Mitsujiro Osawa;Kazuhiro Sudo

  293
  Citations

• Autoantigen-specific interactions with CD4(+) thymocytes control mature medullary thymic epithelial cell cellularity

  Magali Irla;Stéphanie Hugues;Jason Gill;Takeshi Nitta

  291
  Citations

• NF-κB-Inducing Kinase Establishes Self-Tolerance in a Thymic Stroma-Dependent Manner

  Fumiko Kajiura;Shijie Sun;Takashi Nomura;Keisuke Izumi

  269
  Citations

• Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells.

  Simona W. Rossi;Lukas T. Jeker;Tomoo Ueno;Sachiyo Kuse

  267
  Citations

• Murine natural killer cells contribute to the granulomatous reaction caused by mycobacterial cell walls

  I. Apostolou;Y. Takahama;C. Belmant;T. Kawano

  262
  Citations

• Thymoproteasome Shapes Immunocompetent Repertoire of CD8+ T Cells

  Takeshi Nitta;Shigeo Murata;Katsuhiro Sasaki;Hideki Fujii

  258
  Citations

• Coordination between CCR7- and CCR9-mediated chemokine signals in prevascular fetal thymus colonization

  Cunlan Liu;Fumi Saito;Zhijie Liu;Yu Lei

  245
  Citations

• Expression of the Runt domain-encoding PEBP2 alpha genes in T cells during thymic development.

  Masanobu Satake;Shintaro Nomura;Yuko Yamaguchi-Iwai;Yousuke Takahama

  236
  Citations