World's Best Scientists 2026 revealed!

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Microbiology

D-Index
60
Citations
11174
World Ranking
3170
National Ranking
92

Overview

Yossef Av-Gay is affiliated with the University of British Columbia in Canada and conducts research primarily in the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans several subfields including Infectious Diseases, Molecular Biology, Epidemiology, Immunology, and Organic Chemistry, with a particular focus on tuberculosis and related infectious diseases.

The scientist's research topics cover a range of areas, notably:

  • Tuberculosis Research and Epidemiology
  • Mycobacterium research and diagnosis
  • Cancer therapeutics and mechanisms
  • Biochemical and Molecular Research
  • SARS-CoV-2 and COVID-19 Research
  • Phenothiazines and Benzothiazines Synthesis and Activities
  • Immune responses and vaccinations

In recent years, Av-Gay has published studies in various respected journals, with notable recent papers including:

  • "Roles for phthiocerol dimycocerosate lipids in Mycobacterium tuberculosis pathogenesis" (2021) published in Microbiology
  • "High-Content Screening of Eukaryotic Kinase Inhibitors Identify CHK2 Inhibitor Activity Against Mycobacterium tuberculosis" (2020) published in Frontiers in Microbiology
  • "DMN-Tre Labeling for Detection and High-Content Screening of Compounds against Intracellular Mycobacteria" (2020) published in ACS Omega
  • "From infection niche to therapeutic target: the intracellular lifestyle of Mycobacterium tuberculosis" (2021) published in Microbiology
  • "BCG immunomodulation: From the 'hygiene hypothesis' to COVID-19" (2020) published in Immunobiology

Av-Gay's work has been disseminated frequently in journals such as:

  • Microbiology
  • Frontiers in Microbiology
  • ChemMedChem
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Research Square (Research Square)

Several researchers have collaborated repeatedly with Av-Gay, including:

  • Tirosh Shapira
  • Joseph D. Chao
  • Céline Rens
  • Leah Rankine-Wilson
  • Virginia Pichler

The breadth of Av-Gay's research reflects an interdisciplinary approach combining epidemiological, molecular, and biochemical methods. This work focuses heavily on understanding the pathogenesis of Mycobacterium tuberculosis and finding novel therapeutic targets, as well as exploring immunomodulatory effects and responses relevant to infectious diseases like COVID-19.

Best Publications

  • DNA-Based Diagnostic Approaches for Identification of Burkholderia cepacia Complex, Burkholderia vietnamiensis, Burkholderia multivorans,Burkholderia stabilis, and Burkholderia cepacia Genomovars I and III

    Eshwar Mahenthiralingam;Jocelyn Bischof;Sean K. Byrne;Christopher Radomski

  • Synthesis, characterization, and evaluation of antimicrobial and cytotoxic effect of silver and titanium nanoparticles

    Fidel Martinez-Gutierrez;Peggy L. Olive;Adriana Banuelos;Erasmo Orrantia

  • The eukaryotic-like Ser/Thr protein kinases of Mycobacterium tuberculosis.

    Yossef Av-Gay;Martin Everett

  • Mycobacterium tuberculosis protein tyrosine phosphatase (PtpA) excludes host vacuolar-H+–ATPase to inhibit phagosome acidification

    Dennis Wong;Horacio Bach;Jim Sun;Zakaria Hmama

  • Mycobacterium tuberculosis Virulence Is Mediated by PtpA Dephosphorylation of Human Vacuolar Protein Sorting 33B

    Horacio Bach;Kadamba G. Papavinasasundaram;Dennis Wong;Zakaria Hmama

  • Antibacterial activity, inflammatory response, coagulation and cytotoxicity effects of silver nanoparticles.

    Fidel Martínez-Gutierrez;Fidel Martínez-Gutierrez;Emily P. Thi;Judith M. Silverman;Carolina Camargo de Oliveira

  • Immunoevasion and immunosuppression of the macrophage by Mycobacterium tuberculosis

    Zakaria Hmama;Sandra Peña-Díaz;Sunil Joseph;Yossef Av-Gay

  • The Mycobacterium tuberculosis protein serine/threonine kinase PknG is linked to cellular glutamate/glutamine levels and is important for growth in vivo.

    Siobhan Cowley;Mary Ko;Neora Pick;Rayken Chow

  • Mycothiol-Deficient Mycobacterium smegmatis Mutants Are Hypersensitive to Alkylating Agents, Free Radicals, and Antibiotics

    Mamta Rawat;Gerald L. Newton;Mary Ko;Gladys J. Martinez

  • A novel mycothiol-dependent detoxification pathway in mycobacteria involving mycothiol S-conjugate amidase.

    Gerald L. Newton;Yossef Av-Gay;Robert C. Fahey

  • Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis

    Catherine Vilchèze;Yossef Av-Gay;Rodgoun Attarian;Zhen Liu

  • Synergistic Drug Combinations for Tuberculosis Therapy Identified by a Novel High-Throughput Screen

    Santiago Ramón-García;Carol Ng;Hilary Anderson;Joseph D. Chao

  • Species identification and phylogenetic relationships based on partial HSP60 gene sequences within the genus Staphylococcus

    Anita Y. C. Kwok;Shey-Chiang Su;Robert P. Reynolds;Sue J. Bay

  • Nitazoxanide Stimulates Autophagy and Inhibits mTORC1 Signaling and Intracellular Proliferation of Mycobacterium tuberculosis

    Karen K. Y. Lam;Xingji Zheng;Roberto Forestieri;Aruna D. Balgi

  • Protein kinase and phosphatase signaling in Mycobacterium tuberculosis physiology and pathogenesis.

    Joseph Chao;Dennis Wong;Xingji Zheng;Valerie Poirier

  • Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis

    Vikram Saini;Bridgette M. Cumming;Loni Guidry;Dirk A. Lamprecht

  • Deletion of the Mycobacterium tuberculosis pknH Gene Confers a Higher Bacillary Load during the Chronic Phase of Infection in BALB/c Mice

    K. G. Papavinasasundaram;K. G. Papavinasasundaram;Bosco Chan;Ji-Hae Chung;M. Joseph Colston

  • Gaseous nitric oxide bactericidal activity retained during intermittent high-dose short duration exposure

    Chris Miller;Bevin McMullin;Abdi Ghaffari;Alex Stenzler

  • Expression and characterization of the Mycobacterium tuberculosis serine/threonine protein kinase PknB.

    Yossef Av-Gay;Sarwat Jamil;Steven J. Drews

  • Evidence that plant-like genes in Chlamydia species reflect an ancestral relationship between Chlamydiaceae, cyanobacteria, and the chloroplast

    Fiona S.L. Brinkman;Jeffrey L. Blanchard;Artem Cherkasov;Yossef Av-Gay

  • Mycobacterial manipulation of the host cell.

    Anne Lise K. Hestvik;Zakaria Hmama;Yossef Av-Gay

Frequent Co-Authors

David Greenberg
David Greenberg Ben-Gurion University of the Negev
Robert C. Fahey
Robert C. Fahey University of California, San Diego
Gerald L. Newton
Gerald L. Newton University of California, San Diego
William R. Jacobs
William R. Jacobs Albert Einstein College of Medicine
César A.N. Catalán
César A.N. Catalán National University of Tucumán
Raymond J. Andersen
Raymond J. Andersen University of British Columbia
Catherine Vilchèze
Catherine Vilchèze Albert Einstein College of Medicine
Mamadou Daffé
Mamadou Daffé Centre national de la recherche scientifique, CNRS
Steven J. Drews
Steven J. Drews Canadian Blood Services
Lawrence P. McIntosh
Lawrence P. McIntosh University of British Columbia

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