World's Best Scientists 2026 revealed!

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Biology and Biochemistry

D-Index
54
Citations
13655
World Ranking
15455
National Ranking
6451

Overview

Thomas Y. Ma is affiliated with Pennsylvania State University in the United States. Their primary research field is Medicine, with a focus spanning several subfields including Molecular Biology, Neurology, Infectious Diseases, Surgery, and Gastroenterology.

The scientist has contributed notably to research topics such as:

  • Barrier Structure and Function Studies
  • Gut microbiota and health
  • Helicobacter pylori-related gastroenterology studies
  • Geriatric Care and Nursing Homes
  • Long-Term Effects of COVID-19
  • COVID-19 Clinical Research Studies
  • Gastroesophageal reflux and treatments

Thomas Y. Ma's recent papers reflect a range of topics from infectious disease outbreaks to molecular mechanisms in gastrointestinal health. Selected recent publications include:

  • Increased risk of SARS-CoV-2 infection in staff working across different care homes: enhanced CoVID-19 outbreak investigations in London care Homes, 2020, Journal of Infection
  • Investigation of SARS-CoV-2 outbreaks in six care homes in London, April 2020, 2020, EClinicalMedicine
  • Epidemiology of Early Monkeypox Virus Transmission in Sexual Networks of Gay and Bisexual Men, England, 2022, 2022, Emerging Infectious Diseases
  • Matrix Metalloproteinase MMP-12 Promotes Macrophage Transmigration Across Intestinal Epithelial Tight Junctions and Increases Severity of Experimental Colitis, 2021, Journal of Crohn's and Colitis
  • AP2M1 mediates autophagy-induced CLDN2 (claudin 2) degradation through endocytosis and interaction with LC3 and reduces intestinal epithelial tight junction permeability, 2021, Autophagy

The scientist frequently publishes in a number of venues, with multiple papers appearing in:

  • Physiology
  • Journal of Crohn's and Colitis
  • Inflammatory Bowel Diseases
  • bioRxiv (Cold Spring Harbor Laboratory)
  • EClinicalMedicine

Collaborative work is a significant part of Thomas Y. Ma's research activity. Frequent co-authors include:

  • Prashant K. Nighot
  • Meghali Nighot
  • María Saavedra-Campos
  • Karthik Paranthaman
  • Shamez Ladhani

Best Publications

  • TNF-α-induced increase in intestinal epithelial tight junction permeability requires NF-κB activation

    Thomas Y. Ma;Gary K. Iwamoto;Neil T. Hoa;Vimesh Akotia

  • Mechanism of cytokine modulation of epithelial tight junction barrier.

    Rana Al-Sadi;Michel Boivin;Thomas Ma

  • IL-1β Causes an Increase in Intestinal Epithelial Tight Junction Permeability

    Rana M. Al-Sadi;Thomas Y. Ma;Thomas Y. Ma

  • Lipopolysaccharide Causes an Increase in Intestinal Tight Junction Permeability in Vitro and in Vivo by Inducing Enterocyte Membrane Expression and Localization of TLR-4 and CD14

    Shuhong Guo;Rana Al-Sadi;Rana Al-Sadi;Hamid M. Said;Thomas Y. Ma;Thomas Y. Ma

  • Mechanism of TNF-α modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression

    Thomas Y. Ma;Michel A. Boivin;Dongmei Ye;Ali Pedram

  • Molecular mechanism of tumor necrosis factor-α modulation of intestinal epithelial tight junction barrier

    Dongmei Ye;Iris Ma;Thomas Y. Ma

  • Mechanism of IL-1β-Induced Increase in Intestinal Epithelial Tight Junction Permeability

    Rana Al-Sadi;Dongmei Ye;Karol Dokladny;Thomas Y. Ma;Thomas Y. Ma

  • Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier

    Rana Al-Sadi;Khaldun Khatib;Shuhong Guo;Dongmei Ye

  • Lipopolysaccharide Regulation of Intestinal Tight Junction Permeability Is Mediated by TLR4 Signal Transduction Pathway Activation of FAK and MyD88

    Shuhong Guo;Meghali Nighot;Rana Al-Sadi;Rana Al-Sadi;Tarik Alhmoud

  • Isolation and functional characterization of the actin binding region in the tight junction protein ZO-1

    Alan S. Fanning;Thomas Y. Ma;James Melvin Anderson

  • MicroRNA regulation of intestinal epithelial tight junction permeability.

    Dongmei Ye;Shuhong Guo;Rana Al–Sadi;Rana Al–Sadi;Thomas Y. Ma;Thomas Y. Ma

  • Physiologically relevant increase in temperature causes an increase in intestinal epithelial tight junction permeability.

    Karol Dokladny;Pope L. Moseley;Thomas Y. Ma

  • Ethanol modulation of intestinal epithelial tight junction barrier

    Thomas Y. Ma;Don Nguyen;Vuong Bui;Hanh Nguyen

  • Interleukin-6 Modulation of Intestinal Epithelial Tight Junction Permeability Is Mediated by JNK Pathway Activation of Claudin-2 Gene

    Rana Al-Sadi;Dongmei Ye;Michel Boivin;Shuhong Guo

  • TNF-α modulation of intestinal epithelial tight junction barrier is regulated by ERK1/2 activation of Elk-1.

    Rana Al-Sadi;Shuhong Guo;Dongmei Ye;Thomas Y. Ma;Thomas Y. Ma

  • IL-1β-Induced Increase in Intestinal Epithelial Tight Junction Permeability Is Mediated by MEKK-1 Activation of Canonical NF-κB Pathway

    Rana Al-Sadi;Dongmei Ye;Hamid M. Said;Thomas Y. Ma

  • Autophagy Enhances Intestinal Epithelial Tight Junction Barrier Function by Targeting Claudin-2 Protein Degradation

    Prashant K. Nighot;Chien An Andy Hu;Thomas Y. Ma;Thomas Y. Ma

  • IL-1β and the Intestinal Epithelial Tight Junction Barrier

    Lauren W Kaminsky;Rana Al-Sadi;Thomas Y Ma

  • Lipopolysaccharide-Induced Increase in Intestinal Epithelial Tight Permeability Is Mediated by Toll-Like Receptor 4/Myeloid Differentiation Primary Response 88 (MyD88) Activation of Myosin Light Chain Kinase Expression.

    Meghali Nighot;Meghali Nighot;Rana Al-Sadi;Shuhong Guo;Manmeet Rawat;Manmeet Rawat

  • TNF-α Modulation of Intestinal Tight Junction Permeability Is Mediated by NIK/IKK-α Axis Activation of the Canonical NF-κB Pathway

    Rana Al-Sadi;Shuhong Guo;Dongmei Ye;Manmeet Rawat

Frequent Co-Authors

Hamid M. Said
Hamid M. Said University of California, Irvine
Andrzej S. Tarnawski
Andrzej S. Tarnawski Veterans Health Administration
Pope L. Moseley
Pope L. Moseley University of Copenhagen
Ali Pedram
Ali Pedram University of California, Irvine
Michel Boivin
Michel Boivin Université Laval
D. Martin Watterson
D. Martin Watterson Northwestern University
James M. Anderson
James M. Anderson National Institutes of Health
Tongtong Zou
Tongtong Zou University of Maryland, Baltimore
Myriam Gorospe
Myriam Gorospe National Institutes of Health
Patrick S. G. Chain
Patrick S. G. Chain Los Alamos National Laboratory

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