H-Index & Metrics Best Publications

H-Index & Metrics

Discipline name H-index Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 43 Citations 6,866 84 World Ranking 14472 National Ranking 6081

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Apoptosis
  • Cancer

Xian Ming Chen mainly focuses on Cell biology, microRNA, Cholangiocyte, Cryptosporidium parvum and Molecular biology. His research in Cell biology intersects with topics in Microvesicles, Chromatin remodeling, Immune system and Bioinformatics. The concepts of his Immune system study are interwoven with issues in Receptor, Downregulation and upregulation and Transfection.

His studies in microRNA integrate themes in fields like Regulation of gene expression, Gene expression and Gene silencing. He has researched Cryptosporidium parvum in several fields, including Tumor necrosis factor alpha, Cell culture, Fas ligand, Antimicrobial peptides and Gastrointestinal epithelium. His studies deal with areas such as Inhibitor of apoptosis, Apoptosis, Secretion and Transcription factor, Transactivation as well as Molecular biology.

His most cited work include:

  • A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium (427 citations)
  • A Cellular Micro-RNA, let-7i, Regulates Toll-like Receptor 4 Expression and Contributes to Cholangiocyte Immune Responses against Cryptosporidium parvum Infection (366 citations)
  • MicroRNA Microarray Identifies Let-7i as a Novel Biomarker and Therapeutic Target in Human Epithelial Ovarian Cancer (299 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of study are Cell biology, Cryptosporidium parvum, Molecular biology, microRNA and Immune system. His Cell biology study integrates concerns from other disciplines, such as Downregulation and upregulation, Transfection and Cholangiocyte. His Cryptosporidium parvum study incorporates themes from RNA, Cell culture and Actin remodeling.

Xian Ming Chen combines subjects such as Gene expression, Transactivation, Gene, Regulation of gene expression and Transcription with his study of Molecular biology. His microRNA research is multidisciplinary, incorporating perspectives in Intercellular Adhesion Molecule-1, Cancer research and Gene silencing. In Immune system, Xian Ming Chen works on issues like Gastrointestinal epithelium, which are connected to Microvesicles and Immunology.

He most often published in these fields:

  • Cell biology (47.52%)
  • Cryptosporidium parvum (37.62%)
  • Molecular biology (26.73%)

What were the highlights of his more recent work (between 2015-2021)?

  • Cell biology (47.52%)
  • Transcription (11.88%)
  • RNA (8.91%)

In recent papers he was focusing on the following fields of study:

Xian Ming Chen spends much of his time researching Cell biology, Transcription, RNA, Gene and Cryptosporidium parvum. His work deals with themes such as Gene silencing, Epigenetics and Microglia, which intersect with Cell biology. His work carried out in the field of Transcription brings together such families of science as Chromatin, Regulation of gene expression, Transfection and NF-κB.

His RNA research includes themes of Molecular biology and Gene expression. As a part of the same scientific study, Xian Ming Chen usually deals with the Gene, concentrating on Intestinal epithelium and frequently concerns with Gene knockdown, Immune system and Downregulation and upregulation. To a larger extent, Xian Ming Chen studies Microbiology with the aim of understanding Cryptosporidium parvum.

Between 2015 and 2021, his most popular works were:

  • LincRNA-Cox2 Promotes Late Inflammatory Gene Transcription in Macrophages through Modulating SWI/SNF-Mediated Chromatin Remodeling. (99 citations)
  • Long non-coding RNAs (lncRNAs) and their transcriptional control of inflammatory responses. (97 citations)
  • LincRNA-Cox2 modulates TNF-α-induced transcription of Il12b gene in intestinal epithelial cells through regulation of Mi-2/NuRD-mediated epigenetic histone modifications. (55 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Apoptosis
  • Cancer

His primary scientific interests are in Cell biology, Transcription, Gene, Molecular biology and Innate immune system. In the field of Cell biology, his study on Phagocytosis overlaps with subjects such as Chemistry. His research in Transcription intersects with topics in RNA, NF-κB and Gene expression.

His RNA research incorporates themes from Regulation of gene expression, Pathogen, Intestinal epithelium and Virology. His research ties Cryptosporidium parvum and Gene expression together. Xian Ming Chen works mostly in the field of Molecular biology, limiting it down to topics relating to Long non-coding RNA and, in certain cases, Tumor necrosis factor alpha and Chromatin.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium

William Checkley;William Checkley;A. Clinton White;Devan Jaganath;Michael J. Arrowood.
Lancet Infectious Diseases (2015)

491 Citations

A Cellular Micro-RNA, let-7i, Regulates Toll-like Receptor 4 Expression and Contributes to Cholangiocyte Immune Responses against Cryptosporidium parvum Infection

Xian Ming Chen;Patrick L. Splinter;Steven P. O'Hara;Nicholas F. LaRusso.
Journal of Biological Chemistry (2007)

471 Citations

MicroRNA Microarray Identifies Let-7i as a Novel Biomarker and Therapeutic Target in Human Epithelial Ovarian Cancer

Nuo Yang;Sippy Kaur;Stefano Volinia;Joel Greshock.
Cancer Research (2008)

414 Citations

Exosomal miRNAs: Biological properties and therapeutic potential

Guoku Hu;Kristen M. Drescher;Xian Ming Chen.
Frontiers in Genetics (2012)

306 Citations

NF-kappaB p65-dependent transactivation of miRNA genes following Cryptosporidium parvum infection stimulates epithelial cell immune responses.

Rui Zhou;Guoku Hu;Jun Liu;Ai Yu Gong.
PLOS Pathogens (2009)

215 Citations

Multiple TLRs Are Expressed in Human Cholangiocytes and Mediate Host Epithelial Defense Responses to Cryptosporidium parvum via Activation of NF-κB

Xian Ming Chen;Steven P. O'Hara;Jeremy B. Nelson;Patrick L. Splinter.
Journal of Immunology (2005)

209 Citations

MicroRNA-513 Regulates B7-H1 Translation and Is Involved in IFN-γ-Induced B7-H1 Expression in Cholangiocytes

Ai Yu Gong;Rui Zhou;Guoku Hu;Xiaoqing Li.
Journal of Immunology (2009)

197 Citations

Binding of NF-kappaB p65 subunit to the promoter elements is involved in LPS-induced transactivation of miRNA genes in human biliary epithelial cells

Rui Zhou;Guoku Hu;Ai Yu Gong;Xian Ming Chen.
Nucleic Acids Research (2010)

195 Citations

MicroRNA signatures in liver diseases

Xian Ming Chen.
World Journal of Gastroenterology (2009)

160 Citations

Cryptosporidium parvum activates nuclear factor κB in biliary epithelia preventing epithelial cell apoptosis

Xian–Ming Chen;Susan A. Levine;Patrick L. Splinter;Pamela S. Tietz.
Gastroenterology (2001)

136 Citations

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