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Biology and Biochemistry

D-Index
48
Citations
9934
World Ranking
18310
National Ranking
1317

Overview

Takaya Satoh is affiliated with Osaka Metropolitan University in Japan and has contributed extensively to research in the fields of Biochemistry, Genetics, and Molecular Biology, as well as Medicine. Their work primarily focuses on the molecular mechanisms underlying metabolism, diabetes, and cancer, with a particular emphasis on adipose tissue and metabolic processes.

The main topics of their research include:

  • Metabolism, Diabetes, and Cancer
  • Adipose Tissue and Metabolism
  • Pancreatic Function and Diabetes
  • Protein Kinase Regulation and GTPase Signaling
  • Lipid Metabolism and Biosynthesis
  • Adipokines, Inflammation, and Metabolic Diseases
  • Muscle Physiology and Disorders

Satoh's subfields of study cover Molecular Biology, Physiology, Surgery, Cell Biology, and Biochemistry. Their research work is frequently published in prominent scientific journals, including:

  • International Journal of Molecular Sciences
  • Cellular Signalling
  • FEBS Letters

Significant recent papers by Takaya Satoh include:

  • "The guanine nucleotide exchange factor FLJ00068 activates Rac1 in adipocyte insulin signaling" (2020, FEBS Letters)
  • "Regulation of De Novo Lipid Synthesis by the Small GTPase Rac1 in the Adipogenic Differentiation of Progenitor Cells from Mouse White Adipose Tissue" (2023, International Journal of Molecular Sciences)
  • "Impaired Insulin Signaling Mediated by the Small GTPase Rac1 in Skeletal Muscle of the Leptin-Deficient Obese Mouse" (2023, International Journal of Molecular Sciences)
  • "Atrophy of White Adipose Tissue Accompanied with Decreased Insulin-Stimulated Glucose Uptake in Mice Lacking the Small GTPase Rac1 Specifically in Adipocytes" (2021, International Journal of Molecular Sciences)
  • "Diverse Physiological Functions and Regulatory Mechanisms for Signal-Transducing Small GTPases" (2020, International Journal of Molecular Sciences)

Frequent collaborators in their research include:

  • Nobuyuki Takenaka
  • Man Piu Chan
  • Kiko Hasegawa
  • Atsu Aiba
  • Maaya Yamamoto

Overall, Takaya Satoh's research integrates molecular and physiological studies centered on small GTPases, insulin signaling, and adipocyte function, contributing valuable insights into metabolic regulation and related diseases. The investigative work spans experimental studies of signaling pathways, lipid synthesis, and the role of specific proteins in metabolic tissues.

Best Publications

  • Structure and Function of Signal-Transducing GTP-Binding Proteins

    Yoshito Kaziro;Hiroshi Itoh;Tohru Kozasa;Masato Nakafuku

  • Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6.

    T Satoh;S Nakamura;T Taga;T Matsuda

  • Function of Ras as a molecular switch in signal transduction.

    T Satoh;M Nakafuku;Y Kaziro

  • Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP.

    Tadao Shibasaki;Harumi Takahashi;Takashi Miki;Yasuhiro Sunaga

  • Involvement of ras p21 protein in signal-transduction pathways from interleukin 2, interleukin 3, and granulocyte/macrophage colony-stimulating factor, but not from interleukin 4.

    Takaya Satoh;Masato Nakafuku;Atsushi Miyajima;Yoshito Kaziro

  • Regulation of a Novel Human Phospholipase C, PLCε, through Membrane Targeting by Ras

    Chunhua Song;Chang Deng Hu;Misa Masago;Ken Ichi Kariya

  • S. cerevisiae genes IRA1 and IRA2 encode proteins that may be functionally equivalent to mammalian ras GTPase activating protein

    Kazuma Tanaka;Masato Nakafuku;Takaya Satoh;Mark S. Marshall

  • Phosphorylation by Aurora B Converts MgcRacGAP to a RhoGAP during Cytokinesis

    Yukinori Minoshima;Toshiyuki Kawashima;Koichi Hirose;Koichi Hirose;Yukio Tonozuka

  • Platelet-derived growth factor stimulates formation of active p21ras.GTP complex in Swiss mouse 3T3 cells.

    Takaya Satoh;Masami Endo;Masato Nakafuku;Shun Nakamura

  • Accumulation of p21ras.GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity.

    Takaya Satoh;Masami Endo;Masato Nakafuku;Tetsu Akiyama

  • Crucial Role of Phospholipase Cε in Chemical Carcinogen-Induced Skin Tumor Development

    Yunfeng Bai;Hironori Edamatsu;Sakan Maeda;Hiromitsu Saito

  • Differentiation factors, including nerve growth factor, fibroblast growth factor, and interleukin-6, induce an accumulation of an active Ras.GTP complex in rat pheochromocytoma PC12 cells.

    M Nakafuku;T Satoh;Y Kaziro

  • GTP-dependent association of Raf-1 with Ha-Ras: identification of Raf as a target downstream of Ras in mammalian cells.

    Hiroshi Koide;Takaya Satoh;Masato Nakafuku;Yoshito Kaziro

  • Role of the CDC25 Homology Domain of Phospholipase Cε in Amplification of Rap1-dependent Signaling

    Tai Guang Jin;Takaya Satoh;Yanhong Liao;Chunhua Song

  • Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase Cε

    Chunhua Song;Takaya Satoh;Hironori Edamatsu;Dongmei Wu

  • Platelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell types.

    T Satoh;W J Fantl;J A Escobedo;L T Williams

  • Induction of neurite formation in PC12 cells by microinjection of proto-oncogenic Ha-ras protein preincubated with guanosine-5'-O-(3-thiotriphosphate).

    T Satoh;S Nakamura;Y Kaziro

  • Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of glucose transporter 4 to the mouse skeletal muscle sarcolemma

    Shuji Ueda;Sohei Kitazawa;Kota Ishida;Yuki Nishikawa

  • Molecular mechanisms for the regulation of insulin-stimulated glucose uptake by small guanosine triphosphatases in skeletal muscle and adipocytes.

    Takaya Satoh

  • Anti-apoptotic function of Rac in hematopoietic cells

    Kazuhiko Nishida;Yoshito Kaziro;Takaya Satoh

Frequent Co-Authors

Yoshito Kaziro
Yoshito Kaziro Kyoto University
Tohru Kataoka
Tohru Kataoka Kobe University
Masato Nakafuku
Masato Nakafuku Cincinnati Children's Hospital Medical Center
Tetsuya Nosaka
Tetsuya Nosaka Mie University
Toshio Kitamura
Toshio Kitamura University of Tokyo
Hiroshi Itoh
Hiroshi Itoh Yamaguchi University
Sohei Kitazawa
Sohei Kitazawa Ehime University
Tomohiko Taki
Tomohiko Taki Kyorin University
Tohru Kozasa
Tohru Kozasa University of Illinois at Chicago
Yasuhide Hayashi
Yasuhide Hayashi Gunma Children's Medical Center

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