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Robert F. A. Zwaal

Robert F. A. Zwaal

D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
19534
World Ranking
10028
National Ranking
257

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Biochemistry
  • Phospholipid

Robert F. A. Zwaal mostly deals with Biochemistry, Phospholipid, Phosphatidylserine, Prothrombinase and Platelet. His Biochemistry research is multidisciplinary, incorporating perspectives in Biophysics and Thrombin. Robert F. A. Zwaal studies Phospholipid, focusing on Phosphatidylcholine in particular.

Robert F. A. Zwaal combines subjects such as Apolipoprotein H and Beta 2-Glycoprotein I with his study of Phosphatidylcholine. His studies in Phosphatidylserine integrate themes in fields like Phosphatidylethanolamine and Cell biology. His work in Prothrombinase addresses subjects such as Vesicle, which are connected to disciplines such as Calcium in biology.

His most cited work include:

  • Pathophysiologic Implications of Membrane Phospholipid Asymmetry in Blood Cells (1187 citations)
  • Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor (1174 citations)
  • Surface exposure of phosphatidylserine in pathological cells. (579 citations)

What are the main themes of his work throughout his whole career to date?

The scientist’s investigation covers issues in Biochemistry, Phospholipid, Phosphatidylserine, Platelet and Prothrombinase. Robert F. A. Zwaal has researched Biochemistry in several fields, including Molecular biology, Biophysics and Calcium. Robert F. A. Zwaal works on Phospholipid which deals in particular with Phosphatidylcholine.

His research integrates issues of Phosphatidylethanolamine and Cell biology in his study of Phosphatidylserine. His Platelet study combines topics from a wide range of disciplines, such as Hemostasis and Coagulation. His study explores the link between Prothrombinase and topics such as Venom that cross with problems in Sephadex.

He most often published in these fields:

  • Biochemistry (51.85%)
  • Phospholipid (43.52%)
  • Phosphatidylserine (39.81%)

What were the highlights of his more recent work (between 2000-2020)?

  • Biochemistry (51.85%)
  • Phosphatidylserine (39.81%)
  • Phospholipid scramblase (12.04%)

In recent papers he was focusing on the following fields of study:

His main research concerns Biochemistry, Phosphatidylserine, Phospholipid scramblase, Phospholipid and Platelet. Robert F. A. Zwaal interconnects Platelet activation and Molecular biology in the investigation of issues within Biochemistry. His study in Phosphatidylserine is interdisciplinary in nature, drawing from both Phosphatidylcholine and Cell biology.

His Phospholipid scramblase research is multidisciplinary, incorporating elements of Phospholipid scrambling, Biophysics and Ionomycin. His Phospholipid study typically links adjacent topics like Antibody. His research in Thrombin and Prothrombinase are components of Platelet.

Between 2000 and 2020, his most popular works were:

  • Surface exposure of phosphatidylserine in pathological cells. (579 citations)
  • Scott syndrome, a bleeding disorder caused by defective scrambling of membrane phospholipids. (192 citations)
  • Comparison between Ca2+-induced scrambling of various fluorescently labelled lipid analogues in red blood cells. (105 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Biochemistry
  • Internal medicine

His primary areas of investigation include Cell biology, Phosphatidylserine, Phospholipid, Scott syndrome and Phospholipid scramblase. His Cell biology research is multidisciplinary, incorporating perspectives in Platelet and Apoptosis. His Platelet research is multidisciplinary, incorporating elements of Cell activation, Phosphatidylcholine and Transmembrane protein.

His Apoptosis study integrates concerns from other disciplines, such as Enzyme activator, Cell and Receptor. He is involved in the study of Phospholipid that focuses on Phospholipid scrambling in particular. To a larger extent, Robert F. A. Zwaal studies Biochemistry with the aim of understanding Phospholipid scrambling.

Best Publications

  • Pathophysiologic Implications of Membrane Phospholipid Asymmetry in Blood Cells

    Robert F.A. Zwaal;Alan J. Schroit

  • Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor

    M. Galli;T. Barbui;P. Comfurius;C. Maassen

  • Surface exposure of phosphatidylserine in pathological cells.

    R. F. A. Zwaal;P. Comfurius;E. M. Bevers

  • The role of phospholipids and factor Va in the prothrombinase complex.

    J Rosing;G Tans;J W Govers-Riemslag;R F Zwaal

  • Changes in membrane phospholipid distribution during platelet activation

    Edouard M. Bevers;Paul Comfurius;Robert F.A. Zwaal

  • Lupus anticoagulant IgG's (LA) are not directed to phospholipids only, but to a complex of lipid-bound human prothrombin

    E M Bevers;M Galli;T Barbui;P Comfurius

  • Generation of prothrombin-converting activity and the exposure of phosphatidylserine at the outer surface of platelets.

    Edouard M. Bevers;Paul Comfurius;Jan L.M.L. van Rijn;H. Coenraad Hemker

  • Lipid translocation across the plasma membrane of mammalian cells

    Edouard M Bevers;Paul Comfurius;David W.C Dekkers;Robert F.A Zwaal

  • Organization of phospholipids in human red cell membranes as detected by the action of various purified phospholipases.

    R.F.A. Zwaal;B. Roelofsen;P. Comfurius;L.L.M. van Deenen

  • Transbilayer movement of phospholipids in red cell and platelet membranes

    Alan J. Schroit;Robert F.A. Zwaal

  • Prothrombinase activity of human platelets is inhibited by β2-glycoprotein-I

    Johannes Nimpf;Edouard M. Bevers;Paul H.H. Bomans;Uwe Till

  • Lipid-protein interactions in blood coagulation.

    Robert F.A Zwaal;Paul Comfurius;Edouard M Bevers

  • Loss of membrane phospholipid asymmetry in platelets and red cells may be associated with calcium-induced shedding of plasma membrane and inhibition of aminophospholipid translocase.

    Paul Comfurius;Joan M.G. Senden;Roland H.J. Tilly;Alan J. Schroit

  • Comparison of anticoagulant and procoagulant activities of stimulated platelets and platelet-derived microparticles.

    G Tans;J Rosing;MC Thomassen;MJ Heeb

  • The role of activated human platelets in prothrombin and factor X activation.

    J Rosing;JL van Rijn;EM Bevers;G van Dieijen

  • Topological Asymmetry of Phospholipid Metabolism in Rat Erythrocyte Membranes

    Willem Renooij;Lambert M. G. Van Golde;Robert F. A. Zwaal;Laurens L. M. Van Deenen

  • Scott syndrome, a bleeding disorder caused by defective scrambling of membrane phospholipids.

    Robert F.A Zwaal;Paul Comfurius;Edouard M Bevers

  • Role of divalency in the high-affinity binding of anticardiolipin antibody-beta 2-glycoprotein I complexes to lipid membranes.

    George M. Willems;Marie P. Janssen;Maurice M. A. L. Pelsers;Paul Comfurius

  • Complete purification and some properties of phospholipase C from Bacillus cereus

    R.F.A. Zwaal;B. Roelofsen;P. Comfurius;L.L.M. Van Deenen

  • Anticoagulant activity of beta 2-glycoprotein I is potentiated by a distinct subgroup of anticardiolipin antibodies.

    Monica Galli;Paul Comfurius;Tiziano Barbui;Robert F A Zwaal

Frequent Co-Authors

Edouard M. Bevers
Edouard M. Bevers Maastricht University
Paul Comfurius
Paul Comfurius Maastricht University
Jan Rosing
Jan Rosing Maastricht University
Guido Tans
Guido Tans Maastricht University
Tiziano Barbui
Tiziano Barbui FROM-Fondazione per la Ricerca Ospedale di Bergamo
Robert A. Schlegel
Robert A. Schlegel Pennsylvania State University
Patrick Williamson
Patrick Williamson Amherst College
Peter J. Sims
Peter J. Sims University of Rochester
Therese Wiedmer
Therese Wiedmer Scripps Research Institute
Johan W. M. Heemskerk
Johan W. M. Heemskerk Maastricht University

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