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Microbiology

D-Index
60
Citations
15367
World Ranking
3092
National Ranking
1222

Overview

P'ng Loke is affiliated with the National Institutes of Health in the United States. Their research spans multiple fields including Immunology and Microbiology, Biochemistry, Genetics and Molecular Biology, and Medicine. Within these broader areas, they focus particularly on Molecular Biology, Immunology, Parasitology, Infectious Diseases, and Genetics.

Their scientific inquiries address several main topics, including gut microbiota and health, parasites and host interactions, immune cells in cancer, IL-33, ST2, and ILC pathways, inflammatory bowel disease, Clostridium difficile and Clostridium perfringens research, and single-cell and spatial transcriptomics.

P'ng Loke has contributed to numerous publications in a variety of venues. Frequent publication venues include bioRxiv (Cold Spring Harbor Laboratory), The Journal of Immunology, Gastroenterology, Science Immunology, and Cell Host & Microbe.

Among recent papers authored or co-authored by P'ng Loke are:

  • Identification of a nerve-associated, lung-resident interstitial macrophage subset with distinct localization and immunoregulatory properties, 2020, Science Immunology
  • Regulatory T Cells License Macrophage Pro-Resolving Functions During Atherosclerosis Regression, 2020, Circulation Research
  • Altered Immunity of Laboratory Mice in the Natural Environment Is Associated with Fungal Colonization, 2020, Cell Host & Microbe
  • Heterogeneity in the initiation, development and function of type 2 immunity, 2020, Nature Reviews Immunology
  • Rewilding Nod2 and Atg16l1 Mutant Mice Uncovers Genetic and Environmental Contributions to Microbial Responses and Immune Cell Composition, 2020, Cell Host & Microbe

Frequent co-authors include Joseph C. Devlin, Ken Cadwell, Kelly V. Ruggles, Jian-Da Lin, and Oyebola O. Oyesola.

Best Publications

  • Altering the Intestinal Microbiota during a Critical Developmental Window Has Lasting Metabolic Consequences

    Laura M. Cox;Shingo Yamanishi;Jiho Sohn;Alexander V. Alekseyenko

  • PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells.

    P'ng Loke;James P. Allison

  • Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease.

    David Favre;Jeff Mold;Peter W. Hunt;Bittoo Kanwar

  • B7x: A widely expressed B7 family member that inhibits T cell activation

    Xingxing Zang;P'ng Loke;Jayon Kim;Kenneth Murphy

  • PROTEASES IN PARASITIC DISEASES

    James H McKerrow;Conor Caffrey;Ben Kelly;P'ng Loke

  • Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease

    June-Yong Lee;Jason A. Hall;Lina Kroehling;Lin Wu

  • IL-4 dependent alternatively-activated macrophages have a distinctive in vivo gene expression phenotype

    P'ng Loke;P'ng Loke;Meera G Nair;John Parkinson;David Guiliano

  • Helminth infection promotes colonization resistance via type 2 immunity

    Deepshika Ramanan;Rowann Bowcutt;Soo Ching Lee;Mei San Tang

  • Helminth Colonization Is Associated with Increased Diversity of the Gut Microbiota

    Soo Ching Lee;Mei San Tang;Yvonne A. L. Lim;Seow Huey Choy

  • MicroRNA-33–dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis

    Mireille Ouimet;Hasini N. Ediriweera;U. Mahesh Gundra;Frederick J. Sheedy

  • Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct

    Uma Mahesh Gundra;Natasha M Girgis;Dominik Ruckerl;Steve Jenkins

  • Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection

    P'ng Loke;Iain Gallagher;Meera G Nair;Meera G Nair;Xingxing Zang

  • Inflammatory Ly6Chi monocytes and their conversion to M2 macrophages drive atherosclerosis regression

    Karishma Rahman;Yuliya Vengrenyuk;Stephen A. Ramsey;Noemi Rotllan Vila

  • Chitinase and Fizz family members are a generalized feature of nematode infection with selective upregulation of Ym1 and Fizz1 by antigen-presenting cells

    Meera G. Nair;Iain J. Gallagher;Matthew D. Taylor;P'ng Loke

  • Single-cell analysis of fate-mapped macrophages reveals heterogeneity, including stem-like properties, during atherosclerosis progression and regression

    Jian-Da Lin;Hitoo Nishi;Jordan Poles;Xiang Niu

  • Bacterial Sensor Nod2 Prevents Inflammation of the Small Intestine by Restricting the Expansion of the Commensal Bacteroides vulgatus

    Deepshika Ramanan;Mei San Tang;Rowann Bowcutt;P’ng Loke

  • Identification of a nerve-associated, lung-resident interstitial macrophage subset with distinct localization and immunoregulatory properties.

    Basak B. Ural;Stephen T. Yeung;Payal Damani-Yokota;Joseph C. Devlin

  • Alternatively activated macrophages induced by nematode infection inhibit proliferation via cell‐to‐cell contact

    P'ng Loke;Andrew S. MacDonald;Amy Robb;Rick M. Maizels

  • IL-22+ CD4+ T Cells Are Associated with Therapeutic Trichuris trichiura Infection in an Ulcerative Colitis Patient

    Mara J. Broadhurst;Jacqueline M. Leung;Vikram Kashyap;Joseph M. McCune

  • Therapeutic helminth infection of macaques with idiopathic chronic diarrhea alters the inflammatory signature and mucosal microbiota of the colon.

    Mara Jana Broadhurst;Amir Ardeshir;Bittoo Kanwar;Julie Mirpuri

  • Recent Advances in Type-2-Cell-Mediated Immunity: Insights from Helminth Infection

    Nicola L. Harris;P’ng Loke

  • Regulatory T Cells License Macrophage Pro-Resolving Functions During Atherosclerosis Regression

    Monika sharma;Martin Paul Schlegel;Martin Paul Schlegel;Milessa Silva Afonso;Emily J Brown

Frequent Co-Authors

Judith E. Allen
Judith E. Allen University of Manchester
Ken Cadwell
Ken Cadwell New York University
Yvonne A. L. Lim
Yvonne A. L. Lim University of Malaya
Edward A. Fisher
Edward A. Fisher New York University
James P. Allison
James P. Allison The University of Texas MD Anderson Cancer Center
Andrew S. MacDonald
Andrew S. MacDonald University of Manchester
Martin J. Blaser
Martin J. Blaser Rutgers, The State University of New Jersey
Richard Bonneau
Richard Bonneau New York University
Kathryn J. Moore
Kathryn J. Moore New York University Langone Medical Center
Joseph M. McCune
Joseph M. McCune University of California, San Francisco

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