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Philip J. Stephens

Philip J. Stephens

D-Index & Metrics

Medicine

D-Index
103
Citations
69285
World Ranking
7165
National Ranking
3763

Overview

Philip J. Stephens is affiliated with Foundation Medicine in the United States and conducts research primarily in the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Pharmacology, Toxicology and Pharmaceutics. Their work prominently addresses areas related to oncology, cancer research, pulmonary and respiratory medicine, pharmacology, and genetics.

Stephens' main research topics include cancer treatment and pharmacology, breast cancer treatment studies, advanced breast cancer therapies, pharmacogenetics and drug metabolism, estrogen and related hormone effects, and chemical reactions and isotopes.

Recent publications by Stephens include the following papers:

  • Activating PIK3CA Mutations Induce an Epidermal Growth Factor Receptor (EGFR)/Extracellular Signal-regulated Kinase (ERK) Paracrine Signaling Axis in Basal-like Breast Cancer (2020, UNC Libraries)
  • Loss of Heterozygosity at the CYP2D6 Locus in Breast Cancer: Implications for Germline Pharmacogenetic Studies (2021, UNC Libraries)

Stephens frequently collaborates with several researchers, including:

  • Grace O. Silva
  • Charles M. Perou
  • Christian D. Young
  • Lisa J. Zimmerman
  • Daisuke Hoshino

The most common venue for Stephens' publications is UNC Libraries, where they have contributed at least two works. Their research integrates molecular biology and pharmacogenetics to address challenges in cancer treatment, with specific attention to breast cancer and the pharmacological implications of genetic variations.

Best Publications

  • Mutations of the BRAF gene in human cancer

    Helen Davies;Graham R. Bignell;Charles Cox;Philip Stephens

  • Patterns of somatic mutation in human cancer genomes

    Christopher Greenman;Philip Stephens;Raffaella Smith;Gillian L. Dalgliesh

  • Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

    Philip J. Stephens;Chris D. Greenman;Beiyuan Fu;Fengtang Yang

  • Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing

    Garrett M Frampton;Alex Fichtenholtz;Geoff A Otto;Kai Wang

  • Mutational Processes Molding the Genomes of 21 Breast Cancers

    Serena Nik-Zainal;Ludmil B. Alexandrov;David C. Wedge;Peter Van Loo;Peter Van Loo;Peter Van Loo

  • Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers.

    Aaron M. Goodman;Shumei Kato;Lyudmila Bazhenova;Sandip P. Patel

  • A comprehensive catalogue of somatic mutations from a human cancer genome

    Erin D. Pleasance;R. Keira Cheetham;Philip J. Stephens;David J. Mcbride

  • The landscape of cancer genes and mutational processes in breast cancer

    Philip J. Stephens;Patrick S. Tarpey;Helen Davies;Peter Van Loo;Peter Van Loo

  • Exome sequencing identifies frequent mutation of the SWI/SNF Complex Gene PBRM1 in renal carcinoma

    Ignacio Varela;Patrick Tarpey;Keiran Raine;Dachuan Huang

  • The Life History of 21 Breast Cancers

    Serena Nik-Zainal;Peter Van Loo;Peter Van Loo;Peter Van Loo;David C. Wedge;Ludmil B. Alexandrov

  • STK11/LKB1 Mutations and PD-1 Inhibitor Resistance in KRAS-Mutant Lung Adenocarcinoma.

    Ferdinandos Skoulidis;Michael E. Goldberg;Danielle M. Greenawalt;Matthew D. Hellmann

  • Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

    Gillian L. Dalgliesh;Kyle Furge;Chris Greenman;Lina Chen

  • A small-cell lung cancer genome with complex signatures of tobacco exposure

    Erin D. Pleasance;Philip J. Stephens;Sarah O’Meara;Sarah O’Meara;David J. McBride

  • Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies

    Doron Lipson;Marzia Capelletti;Roman Yelensky;Geoff Otto

  • Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

    Gijs Van Haaften;Gillian L Dalgliesh;Helen Davies;Lina Chen

  • Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors

    Garrett M. Frampton;Siraj M. Ali;Mark Rosenzweig;Juliann Chmielecki

  • Emergence of constitutively active estrogen receptor-α mutations in pretreated advanced estrogen receptor positive breast cancer

    Rinath Jeselsohn;Roman Yelensky;Gilles Buchwalter;Gilles Buchwalter;Garrett Frampton

  • Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer.

    Aria Vaishnavi;Marzia Capelletti;Anh T Le;Severine Kako

  • Molecular profiling of cancer patients enables personalized combination therapy: the I-PREDICT study

    Jason K. Sicklick;Shumei Kato;Ryosuke Okamura;Maria Schwaederle

  • Kinase fusions are frequent in Spitz tumours and spitzoid melanomas.

    Thomas Wiesner;Jie He;Roman Yelensky;Rosaura Esteve-Puig

Frequent Co-Authors

Siraj M. Ali
Siraj M. Ali Foundation Medicine
Jeffrey S. Ross
Jeffrey S. Ross Foundation Medicine
Garrett M. Frampton
Garrett M. Frampton Foundation Medicine
Sai-Hong Ignatius Ou
Sai-Hong Ignatius Ou University of California, Irvine
Ross L. Levine
Ross L. Levine Memorial Sloan Kettering Cancer Center
Michael R. Stratton
Michael R. Stratton Wellcome Sanger Institute
Funda Meric-Bernstam
Funda Meric-Bernstam The University of Texas MD Anderson Cancer Center
Marcel R.M. van den Brink
Marcel R.M. van den Brink Memorial Sloan Kettering Cancer Center
Razelle Kurzrock
Razelle Kurzrock Medical College of Wisconsin

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