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Microbiology

D-Index
57
Citations
9563
World Ranking
3626
National Ranking
1425

Overview

Paul Spearman is affiliated with Cincinnati Children's Hospital Medical Center in the United States. Their research primarily focuses on Medicine and Immunology and Microbiology, with a particular concentration in Infectious Diseases, Epidemiology, Virology, Immunology, and Molecular Biology. The scientist's work encompasses several main topics including HIV Research and Treatment, SARS-CoV-2 and COVID-19 Research, Respiratory Viral Infections Research, COVID-19 Clinical Research Studies, Cellular Transport and Secretion, Viral Infections and Outbreaks Research, and Neuroinflammation and Neurodegeneration Mechanisms.

The scientist has contributed to numerous peer-reviewed publications, with recent notable papers including:

  • "Warp Speed for Coronavirus Disease 2019 (COVID-19) Vaccines: Why Are Children Stuck in Neutral?" (2020) in Clinical Infectious Diseases
  • "Comparative analysis of human microglial models for studies of HIV replication and pathogenesis" (2020) in Retrovirology
  • "Advances in HIV-1 Assembly" (2022) in Viruses
  • "Intranasal parainfluenza virus type 5 (PIV5)-vectored RSV vaccine is safe and immunogenic in healthy adults in a phase 1 clinical study" (2023) in Science Advances
  • "Adipocyte inflammation and pathogenesis of viral pneumonias: an overlooked contribution" (2021) in Mucosal Immunology

Spearman frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Journal of Virology, Vaccine, The Pediatric Infectious Disease Journal, and Research Square (Research Square).

The scientist has collaborated extensively with several coauthors, including J. Hammonds, Lingmei Ding, Karnail Singh, Grigoriy Lerner, and Krista Dienger-Stambaugh.

Best Publications

  • Neonatal infectious diseases: evaluation of neonatal sepsis.

    Andres Camacho-Gonzalez;Paul W. Spearman;Barbara J. Stoll

  • Human immunodeficiency virus type 1 viral protein R localization in infected cells and virions.

    Yuh-Ling Lu;P. Spearman;L. Ratner

  • Identification of human immunodeficiency virus type 1 Gag protein domains essential to membrane binding and particle assembly.

    P Spearman;J J Wang;N Vander Heyden;L Ratner

  • AP-3 directs the intracellular trafficking of HIV-1 Gag and plays a key role in particle assembly.

    Xinhong Dong;Hua Li;Aaron Derdowski;Lingmei Ding

  • Membrane binding of human immunodeficiency virus type 1 matrix protein in vivo supports a conformational myristyl switch mechanism.

    Paul Spearman;Robert Horton;Lee Ratner;Irina Kuli-Zade

  • Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans

    Ali H Ellebedy;Florian Krammer;Gui-Mei Li;Matthew S Miller

  • Viral protein U counteracts a human host cell restriction that inhibits HIV-1 particle production.

    Vasundhara Varthakavi;Rita M. Smith;Stephan P. Bour;Klaus Strebel

  • HIV‐1 Egress is Gated Through Late Endosomal Membranes

    Sascha Nydegger;Michelangelo Foti;Aaron Derdowski;Paul Spearman

  • Immunoelectron microscopic evidence for Tetherin/BST2 as the physical bridge between HIV-1 virions and the plasma membrane.

    Jason Edward Hammonds;Jaang-Jiun Wang;Hong Yi;Paul Spearman

  • The I Domain Is Required for Efficient Plasma Membrane Binding of Human Immunodeficiency Virus Type 1 Pr55Gag

    Stephanie Sandefur;Vasundhara Varthakavi;Paul Spearman

  • QS-21 promotes an adjuvant effect allowing for reduced antigen dose during HIV-1 envelope subunit immmunization in humans

    Thomas G. Evans;M.Juliana McElrath;Tom Matthews;David Montefiori

  • Mapping and characterization of the N-terminal I domain of human immunodeficiency virus type 1 Pr55(Gag).

    Stephanie Sandefur;Rita M. Smith;Vasundhara Varthakavi;Paul Spearman

  • APOBEC3G Multimers Are Recruited to the Plasma Membrane for Packaging into Human Immunodeficiency Virus Type 1 Virus-Like Particles in an RNA-Dependent Process Requiring the NC Basic Linker

    Atuhani Burnett;Paul Spearman

  • Serological responses to an avian influenza A/H7N9 vaccine mixed at the point-of-use with MF59 adjuvant: a randomized clinical trial.

    Mark J. Mulligan;David I. Bernstein;Patricia Winokur;Richard Rupp

  • Safety and immunogenicity of a high-titered canarypox vaccine in combination with rgp120 in a diverse population of HIV-1-uninfected adults: AIDS Vaccine Evaluation Group Protocol 022A.

    Kalpana Gupta;Michael Hudgens;Lawrence Corey;M. Juliana McElrath

  • Correlated fluorescence microscopy and cryo-electron tomography of virus-infected or transfected mammalian cells

    Cheri M Hampton;Joshua D Strauss;Zunlong Ke;Rebecca S Dillard

  • The pericentriolar recycling endosome plays a key role in Vpu-mediated enhancement of HIV-1 particle release.

    Vasundhara Varthakavi;Rita M. Smith;Kenneth L. Martin;Aaron Derdowski

  • A Novel Fluorescence Resonance Energy Transfer Assay Demonstrates that the Human Immunodeficiency Virus Type 1 Pr55Gag I Domain Mediates Gag-Gag Interactions

    Aaron Derdowski;Lingmei Ding;Paul Spearman

  • Myristoylation Is Required for Human Immunodeficiency Virus Type 1 Gag-Gag Multimerization in Mammalian Cells

    Hua Li;Jun Dou;Lingmei Ding;Paul Spearman

  • Human immunodeficiency virus replication in a primary effusion lymphoma cell line stimulates lytic-phase replication of Kaposi's sarcoma-associated herpesvirus

    Vasundhara Varthakavi;Philip J. Browning;Paul Spearman

  • A RhoA-derived peptide inhibits syncytium formation induced by respiratory syncytial virus and parainfluenza virus type 3

    Manoj K. Pastey;Tara L. Gower;Paul W. Spearman;James E. Crowe

Frequent Co-Authors

M. Juliana McElrath
M. Juliana McElrath University of Washington
Mark J. Mulligan
Mark J. Mulligan New York University
David C. Montefiori
David C. Montefiori Duke University
Sharon E. Frey
Sharon E. Frey Saint Louis University
Georgia D. Tomaras
Georgia D. Tomaras Duke University
Hin Chu
Hin Chu University of Hong Kong
Lee Ratner
Lee Ratner Washington University in St. Louis
James E. Crowe
James E. Crowe Vanderbilt University Medical Center
Spyros A. Kalams
Spyros A. Kalams Vanderbilt University Medical Center
Eric Hunter
Eric Hunter Emory University

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