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Neuroscience

D-Index
78
Citations
27547
World Ranking
1739
National Ranking
181

Overview

Nicholas P. Franks is a researcher affiliated with Imperial College London in the United Kingdom. Their work centers primarily on the field of neuroscience, with a significant focus on sleep and wakefulness research.

Their main fields of study include:

  • Neuroscience

Within this broad discipline, they have contributed extensively across several subfields, including:

  • Cognitive Neuroscience
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience
  • Experimental and Cognitive Psychology
  • Developmental Neuroscience

Their research topics often explore areas related to sleep and circadian rhythms, notably:

  • Sleep and Wakefulness Research
  • Circadian rhythm and melatonin
  • Sleep and related disorders
  • Neuroscience and Neuropharmacology Research
  • Neuroscience of respiration and sleep
  • Anesthesia and Neurotoxicity Research
  • Traumatic Brain Injury and Neurovascular Disturbances

Nicholas P. Franks has published in a variety of scientific venues. The most frequent publication venues include:

  • Nature Neuroscience
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Science
  • Ecological Entomology
  • Interface Focus

Examples of recent papers authored or co-authored by Franks are:

  • "Sleep deprivation and stress: a reciprocal relationship," 2020, Interface Focus
  • "Brain clearance is reduced during sleep and anesthesia," 2024, Nature Neuroscience
  • "A specific circuit in the midbrain detects stress and induces restorative sleep," 2022, Science
  • "The inescapable drive to sleep: Overlapping mechanisms of sleep and sedation," 2021, Science
  • "Somatostatin neurons in prefrontal cortex initiate sleep-preparatory behavior and sleep via the preoptic and lateral hypothalamus," 2023, Nature Neuroscience

Frequent collaborators in their research efforts include:

  • William Wisden
  • Raquel Yustos
  • Alexei L. Vyssotski
  • Xiao Yu
  • Mathieu Nollet

Best Publications

  • Molecular and cellular mechanisms of general anaesthesia

    N P Franks;W R Lieb

  • Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites

    Stephen Curry;Hendrik Mandelkow;Peter Brick;Nick Franks

  • General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal

    Nicholas P. Franks

  • The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects.

    Laura E. Nelson;Jun Lu;Tianzhi Guo;Clifford B. Saper

  • Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes.

    Elena Conti;Nick P Franks;Peter Brick

  • Do general anaesthetics act by competitive binding to specific receptors

    N. P. Franks;W. R. Lieb

  • How does xenon produce anaesthesia

    N. P. Franks;R. Dickinson;S. L. M. de Sousa;A. C. Hall

  • The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway.

    L. E. Nelson;T. Z. Guo;J. Lu;C. B. Saper

  • Molecular mechanisms of general anaesthesia

    N. P. Franks;W. R. Lieb

  • Structural analysis of hydrated egg lecithin and cholesterol bilayers I. X-ray diffraction

    D.L. Worcester;N.P. Franks

  • Molecular targets underlying general anaesthesia

    Nicholas P Franks

  • Two-pore-domain K+ channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane.

    Marco Gruss;Trevor J. Bushell;Damian P. Bright;William R. Lieb

  • Dexmedetomidine produces its neuroprotective effect via the α2A-adrenoceptor subtype

    Daqing Ma;Mahmuda Hossain;Nishanthan Rajakumaraswamy;Mubarik Arshad

  • Xenon Mitigates Isoflurane-induced Neuronal Apoptosis in the Developing Rodent Brain

    Daqing Ma;Peter Williamson;Adam Januszewski;Marie-Caroline Nogaro

  • Stereospecific effects of inhalational general anesthetic optical isomers on nerve ion channels.

    NP Franks;WR Lieb

  • The structure of lipid bilayers and the effects of general anaesthetics. An x-ray and neutron diffraction study.

    N.P. Franks;W.R. Lieb

  • Contrasting Synaptic Actions of the Inhalational General Anesthetics Isoflurane and Xenon

    Sara L. M. de Sousa;Robert Dickinson;William R. Lieb;Nicholas P. Franks

  • Competitive Inhibition at the Glycine Site of the N -Methyl-d-aspartate Receptor by the Anesthetics Xenon and IsofluraneEvidence from Molecular Modeling and Electrophysiology

    Robert Dickinson;Brian K. Peterson;Paul Banks;Constantinos Simillis

  • Xenon and Hypothermia Combine to Provide Neuroprotection from Neonatal Asphyxia

    Daqing Ma;Mahmuda Hossain;Andre Chow;Mubarik Arshad

  • GABA and glutamate neurons in the VTA regulate sleep and wakefulness

    Xiao Yu;Wen Li;Ying Ma;Kyoko Tossell

  • SELECTIVE ACTIONS OF VOLATILE GENERAL ANAESTHETICS AT MOLECULAR AND CELLULAR LEVELS

    N.P. Franks;W.R. Lieb

  • Differential sensitivities of mammalian neuronal and muscle nicotinic acetylcholine receptors to general anesthetics

    J. M. Violet;D. L. Downie;R. C. Nakisa;W. R. Lieb

Frequent Co-Authors

William Wisden
William Wisden Imperial College London
Stephen G. Brickley
Stephen G. Brickley Imperial College London
Jun Lu
Jun Lu Zhejiang University
Clifford B. Saper
Clifford B. Saper Beth Israel Deaconess Medical Center
Joan J. Kendig
Joan J. Kendig Stanford University
Mark A. Ungless
Mark A. Ungless Imperial College London
Thomas E. Scammell
Thomas E. Scammell Harvard Medical School
Alain Buisson
Alain Buisson Grenoble Alpes University
Denis Burdakov
Denis Burdakov ETH Zurich

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