World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
14352
World Ranking
9195
National Ranking
4074

Overview

Lee E. Limbird is affiliated with Fisk University in the United States. Their research primarily engages with the fields of Biochemistry, Genetics and Molecular Biology, exploring a range of subfields including Genetics, Endocrinology, Diabetes and Metabolism, and Molecular Biology.

Their scholarly work focuses on topics related to Estrogen and related hormone effects, Hormonal Regulation and Hypertension, and Receptor Mechanisms and Signaling. These areas reflect a consistent interest in understanding hormonal functions and receptor activities at the molecular level.

Limbird's recent publications comprise two notable papers. The first, published in 2022 in Pharmacology Research & Perspectives, is titled Correlation of functional and radioligand binding characteristics of GPER ligands confirming aldosterone as a GPER agonist. The second paper, Pushing Forward the Future Tense: Perspectives of a Scientist, appeared in 2021 in The Annual Review of Pharmacology and Toxicology.

The scientist has collaborated with several frequent coauthors, including Qingming Ding, Jozef Chorazyczewski, Robert Gros, Harvey Motulsky, and Ross D. Feldman. These partnerships illustrate an active engagement in collaborative research efforts across their areas of expertise.

Their work appears consistently in specialized journals, notably in Pharmacology Research & Perspectives and The Annual Review of Pharmacology and Toxicology, where they have contributed at least one publication each.

Best Publications

  • Central hypotensive effects of the alpha2a-adrenergic receptor subtype.

    Leigh B. MacMillan;Lutz Hein;Marta S. Smith;Michael T. Piascik

  • Cell surface receptors : a short course on theory and methods

    Lee E. Limbird

  • Receptors linked to inhibition of adenylate cyclase: additional signaling mechanisms.

    Lee E. Limbird

  • Substitution of a mutant alpha2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo.

    Parul P. Lakhlani;Leigh B. MacMillan;Tian Zhi Guo;Brian A. McCool

  • Abnormal regulation of the sympathetic nervous system in alpha2A-adrenergic receptor knockout mice.

    John D. Altman;Anne U. Trendelenburg;Leigh MacMillan;Dan Bernstein

  • Mutational analysis of the ligand binding domain of the low density lipoprotein receptor.

    V Esser;L E Limbird;M S Brown;J L Goldstein

  • G protein-coupled receptor interacting proteins: emerging roles in localization and signal transduction.

    Ashley E Brady;Lee E Limbird

  • An aspartate conserved among G-protein receptors confers allosteric regulation of alpha 2-adrenergic receptors by sodium.

    D A Horstman;S Brandon;A L Wilson;C A Guyer

  • The alpha2a adrenergic receptor subtype mediates spinal analgesia evoked by alpha2 agonists and is necessary for spinal adrenergic-opioid synergy.

    Laura S. Stone;Leigh B. MacMillan;Kelley F. Kitto;Lee E. Limbird

  • The α2A-Adrenergic Receptor Plays a Protective Role in Mouse Behavioral Models of Depression and Anxiety

    Nicole L. Schramm;Michael P. McDonald;Lee E. Limbird

  • Membrane trafficking of G protein-coupled receptors.

    Christopher M. Tan;Ashley E. Brady;Hilary Highfield Nickols;Qin Wang

  • Agonist-promoted coupling of the beta-adrenergic receptor with the guanine nucleotide regulatory protein of the adenylate cyclase system.

    L E Limbird;D M Gill;R J Lefkowitz

  • Mutation of the α2A-Adrenoceptor Impairs Working Memory Performance and Annuls Cognitive Enhancement by Guanfacine

    Jenna S. Franowicz;Lynn E. Kessler;Catherine M. Dailey Borja;Brian K. Kobilka

  • Evidence that Na+/H+ exchange regulates receptor-mediated phospholipase A2 activation in human platelets.

    J D Sweatt;T M Connolly;E J Cragoe;L E Limbird

  • β-Adrenergic receptors: Evidence for negative cooperativity

    Lee E. Limbird;Pierre De Meyts;Robert J. Lefkowitz

  • A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents.

    Annmarie Surprenant;Debra A. Horstman;Hamid Akbarali;Lee E. Limbird

  • Coupling of the alpha 2A-adrenergic receptor to multiple G-proteins. A simple approach for estimating receptor-G-protein coupling efficiency in a transient expression system.

    O Chabre;B R Conklin;S Brandon;H R Bourne

  • Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors.

    Qin Wang;Jiali Zhao;Ashley E. Brady;Jian Feng

  • Inhibitors of Na+/H+ exchange block epinephrine- and ADP-induced stimulation of human platelet phospholipase C by blockade of arachidonic acid release at a prior step.

    J D Sweatt;I A Blair;E J Cragoe;L E Limbird

  • Resolution of beta-adrenergic receptor binding and adenylate cyclase activity by gel exclusion chromatography.

    L E Limbird;R J Lefkowitz

Frequent Co-Authors

Robert J. Lefkowitz
Robert J. Lefkowitz Duke University
Mervyn Maze
Mervyn Maze University of California, San Francisco
David M. Lovinger
David M. Lovinger National Institutes of Health
Galen S. Wagner
Galen S. Wagner Duke University
Brian K. Kobilka
Brian K. Kobilka Stanford University
Marc G. Caron
Marc G. Caron Duke University
Deborah L. Segaloff
Deborah L. Segaloff University of Iowa
Jodi Nunnari
Jodi Nunnari University of California, Davis
Lewis T. Williams
Lewis T. Williams University of California, San Francisco
Paul Greengard
Paul Greengard Rockefeller University

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