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Microbiology

D-Index
46
Citations
8023
World Ranking
4904
National Ranking
1895

Overview

Krisztina M. Papp-Wallace is a researcher affiliated with Case Western Reserve University in the United States. Their work spans several fields with a strong focus on biochemical and medical aspects of infectious diseases and antibiotic resistance.

The primary fields of study in their research include Biochemistry, Genetics and Molecular Biology and Medicine. Subfields of particular interest are Molecular Medicine, Pharmacology, Epidemiology, Molecular Biology, and Endocrinology, reflecting a multidisciplinary approach to understanding bacterial resistance and treatment strategies.

The main research topics covered by their work are:

  • Antibiotic Resistance in Bacteria
  • Antibiotics Pharmacokinetics and Efficacy
  • Bacterial biofilms and quorum sensing
  • Burkholderia infections and melioidosis
  • Plant Pathogenic Bacteria Studies
  • Antibiotic Use and Resistance
  • Vibrio bacteria research studies

Several frequent coauthors collaborate regularly with this researcher, including:

  • Robert A. Bonomo (36 coauthored works)
  • Christopher R. Bethel (18 coauthored works)
  • Focco van den Akker (13 coauthored works)
  • Scott A. Becka (12 coauthored works)
  • Elise T. Zeiser (11 coauthored works)

The most frequent publication venues for their research are:

  • Antimicrobial Agents and Chemotherapy (16 publications)
  • Open Forum Infectious Diseases (7 publications)
  • Antibiotics (4 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (3 publications)
  • mBio (2 publications)

Important research papers include:

  • Resistance to Novel β-Lactam-β-Lactamase Inhibitor Combinations, 2020, Infectious Disease Clinics of North America
  • Structural Characterization of the D179N and D179Y Variants of KPC-2 β-Lactamase: Ω-Loop Destabilization as a Mechanism of Resistance to Ceftazidime-Avibactam, 2022, Antimicrobial Agents and Chemotherapy
  • Cerebrospinal fluid (CSF) augments metabolism and virulence expression factors in Acinetobacter baumannii, 2021, Scientific Reports
  • Durlobactam, a Broad-Spectrum Serine β-lactamase Inhibitor, Restores Sulbactam Activity Against Acinetobacter Species, 2023, Clinical Infectious Diseases
  • A γ-Lactam Siderophore Antibiotic Effective against Multidrug-Resistant Gram-Negative Bacilli, 2020, Journal of Medicinal Chemistry

Best Publications

  • Carbapenems: Past, Present, and Future

    Krisztina M. Papp-Wallace;Andrea Endimiani;Andrea Endimiani;Andrea Endimiani;Magdalena A. Taracila;Robert A. Bonomo

  • New β-Lactamase Inhibitors: a Therapeutic Renaissance in an MDR World

    Sarah M. Drawz;Krisztina M. Papp-Wallace;Krisztina M. Papp-Wallace;Robert A. Bonomo

  • Manganese Transport and the Role of Manganese in Virulence

    Krisztina M. Papp-Wallace;Michael E. Maguire

  • Can Ceftazidime-Avibactam and Aztreonam Overcome β-Lactam Resistance Conferred by Metallo-β-Lactamases in Enterobacteriaceae?

    Steven Marshall;Andrea M. Hujer;Andrea M. Hujer;Laura J. Rojas;Laura J. Rojas;Krisztina M. Papp-Wallace

  • Inhibitor Resistance in the KPC-2 β-Lactamase, a Preeminent Property of This Class A β-Lactamase

    Krisztina M. Papp-Wallace;Christopher R. Bethel;Anne M. Distler;Courtney Kasuboski

  • New β-Lactamase Inhibitors in the Clinic

    Krisztina M. Papp-Wallace;Robert A. Bonomo

  • Treatment options for infections caused by carbapenem-resistant Enterobacteriaceae: can we apply “precision medicine” to antimicrobial chemotherapy?

    Federico Perez;Nadim G El Chakhtoura;Krisztina M Papp-Wallace;Brigid M Wilson

  • Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using β-Lactamase Inhibitors and β-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234

    Krisztina M. Papp-Wallace;Nhu Q. Nguyen;Michael R. Jacobs;Christopher R. Bethel

  • WCK 5107 (Zidebactam) and WCK 5153 Are Novel Inhibitors of PBP2 Showing Potent "β-Lactam Enhancer" Activity against Pseudomonas aeruginosa, Including Multidrug-Resistant Metallo-β-Lactamase-Producing High-Risk Clones.

    Bartolome Moya;Isabel M. Barcelo;Sachin Bhagwat;Mahesh Patel

  • Unexpected Challenges in Treating Multidrug-Resistant Gram-Negative Bacteria: Resistance to Ceftazidime-Avibactam in Archived Isolates of Pseudomonas aeruginosa

    Marisa L. Winkler;Krisztina M. Papp-Wallace;Andrea M. Hujer;T. Nicholas Domitrovic

  • Klebsiella pneumoniae Carbapenemase-2 (KPC-2), Substitutions at Ambler Position Asp179, and Resistance to Ceftazidime-Avibactam: Unique Antibiotic-Resistant Phenotypes Emerge from β-Lactamase Protein Engineering.

    Melissa D. Barnes;Melissa D. Barnes;Marisa L. Winkler;Marisa L. Winkler;Magdalena A. Taracila;Magdalena A. Taracila;Malcolm G. Page

  • Activity of ceftazidime/avibactam against isogenic strains of Escherichia coli containing KPC and SHV β-lactamases with single amino acid substitutions in the Ω-loop

    Marisa L. Winkler;Krisztina M. Papp-Wallace;Robert A. Bonomo

  • The latest advances in β-lactam/β-lactamase inhibitor combinations for the treatment of Gram-negative bacterial infections.

    Krisztina M. Papp-Wallace

  • Deciphering the evolution of cephalosporin resistance to ceftolozane-tazobactam in pseudomonas aeruginosa

    Melissa D. Barnes;Melissa D. Barnes;Magdalena A. Taracila;Magdalena A. Taracila;Joseph D. Rutter;Christopher R. Bethel

  • Resistance to Novel β-Lactam-β-Lactamase Inhibitor Combinations: The "Price of Progress".

    Krisztina M. Papp-Wallace;Andrew R. Mack;Magdalena A. Taracila;Robert A. Bonomo

  • Targeting Multidrug-Resistant Acinetobacter spp.: Sulbactam and the Diazabicyclooctenone β-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent.

    Melissa D. Barnes;Melissa D. Barnes;Vijay Kumar;Christopher R. Bethel;Samir H. Moussa

  • Non-phenotypic tests to detect and characterize antibiotic resistance mechanisms in Enterobacteriaceae.

    Agnese Lupo;Krisztina M. Papp-Wallace;Krisztina M. Papp-Wallace;Parham Sendi;Robert A. Bonomo;Robert A. Bonomo

  • Variants of β-Lactamase KPC-2 That Are Resistant to Inhibition by Avibactam

    Krisztina M. Papp-Wallace;Marisa L. Winkler;Magdalena A. Taracila;Magdalena A. Taracila;Robert A. Bonomo

  • Relebactam Is a Potent Inhibitor of the KPC-2 β-Lactamase and Restores Imipenem Susceptibility in KPC-Producing Enterobacteriaceae

    Krisztina M. Papp-Wallace;Krisztina M. Papp-Wallace;Melissa D. Barnes;Melissa D. Barnes;Jim Alsop;Magdalena A. Taracila;Magdalena A. Taracila

  • Beyond Piperacillin-Tazobactam: Cefepime and AAI101 as a Potent β-Lactam-β-Lactamase Inhibitor Combination.

    Krisztina M Papp-Wallace;Christopher R Bethel;Jocelyne Caillon;Melissa D Barnes;Melissa D Barnes

  • Exploring the Role of a Conserved Class A Residue in the Ω-Loop of KPC-2 β-Lactamase A MECHANISM FOR CEFTAZIDIME HYDROLYSIS

    Peter S. Levitt;Krisztina M. Papp-Wallace;Magdalena A. Taracila;Andrea M. Hujer

  • Novel β-lactamase inhibitors: a therapeutic hope against the scourge of multidrug resistance

    Richard Watkins;Krisztina M. Papp-Wallace;Sarah M. Drawz;Robert Anthony Bonomo

  • Molecular Investigations of PenA-mediated β-lactam Resistance in Burkholderia pseudomallei.

    Drew A. Rholl;Krisztina M. Papp-Wallace;Andrew P. Tomaras;Michael L. Vasil

Frequent Co-Authors

Robert A. Bonomo
Robert A. Bonomo Case Western Reserve University
Michael R. Jacobs
Michael R. Jacobs University Hospitals of Cleveland
Robert A. Bonomo
Robert A. Bonomo Case Western Reserve University
Kristine M. Hujer
Kristine M. Hujer Case Western Reserve University
Federico Perez
Federico Perez Case Western Reserve University
Andrea M. Hujer
Andrea M. Hujer United States Department of Veterans Affairs
John J. LiPuma
John J. LiPuma University of Michigan–Ann Arbor
Marcelo E. Tolmasky
Marcelo E. Tolmasky California State University, Fullerton
Alejandro J. Vila
Alejandro J. Vila National University of Rosario
Andrea Endimiani
Andrea Endimiani University of Bern

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